DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ras and IMD3

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_013536.3	Gene:	IMD3 / 851152	SGDID:	S000004424	Length:	523	Species:	Saccharomyces cerevisiae

Alignment Length:	502	Identity:	308/502 - (61%)
Similarity:	385/502 - (76%)	Gaps:	4/502 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DGLSCKELFQNGE--GLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDTVTESEM 100
            ||||.:||..:..  ||||||||:|||.:||.:.||.|.:.||:::||..|.|||||||||||||
Yeast    21 DGLSVQELMDSKTRGGLTYNDFLVLPGLVDFPSSEVSLQTKLTRNITLNTPFVSSPMDTVTESEM 85

  Fly   101 AIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKNGFTGYP 165
            ||.|||.||||.||||||||.||..|.:||.|::||:.:|.|:|||.|||:....:.:.||:|:|
Yeast    86 AIFMALLGGIGFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEAKSMKERFGFSGFP 150

  Fly   166 VTENGKLGGKLLGMVTSRDIDFRENQPEVLLADIMTTELVTAPNGINLPTANAILEKSKKGKLPI 230
            |||:||..|||:|:||||||.|.|:. .:|:.|:||...||...||.|...|.||:|.|||||.|
Yeast   151 VTEDGKRNGKLMGIVTSRDIQFVEDN-SLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGKLLI 214

  Fly   231 VNQAGELVAMIARTDLKKARSYPNASKD-SNKQLLVGAAIGTRSEDKARLALLVANGVDVIILDS 294
            |:..|.||:|::||||.|.::||.|||. :.||||.||||||...||.||.|||..|:||:||||
Yeast   215 VDDNGNLVSMLSRTDLMKNQNYPLASKSATTKQLLCGAAIGTIDADKERLRLLVEAGLDVVILDS 279

  Fly   295 SQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICITQEVMACG 359
            |||||::|:.|||:||||:|:|::|.|||.||.||.|||.||.||||:|||||||||||||||||
Yeast   280 SQGNSIFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGSICITQEVMACG 344

  Fly   360 CPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGASAVMMGSLLAGTSEAPGEYFFSDG 424
            .||.||||.|..:|.|||:|.:||||:|:||||.||:|||:|.||||.:||||:|:|||||:.||
Yeast   345 RPQGTAVYNVCEFANQFGIPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTESPGEYFYQDG 409

  Fly   425 VRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVDKGSVLRYLPYLECGLQH 489
            .|||.||||||::||::...||.|.:..|.:|.|.:.|||||||::|||||:.:::|||..||||
Yeast   410 KRLKAYRGMGSIDAMQKTGTKGNASTSRYFSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQH 474

  Fly   490 SCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLFSYEKRL 536
            ||||||..|:..|::.:.:|::||..||.||||||.||.|.||||||
Yeast   475 SCQDIGYKSLTLLKENVQSGKVRFEFRTASAQLEGGVHNLHSYEKRL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	303/497 (61%)
IMD3	NP_013536.3	PTZ00314	21..518	CDD:240355	303/497 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	589	1.000	Domainoid score	I27
eggNOG	1	0.900	-	-		E1_COG0516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68096
Inparanoid	1	1.050	606	1.000	Inparanoid score	I129
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62889
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm46774
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	LDO	PTHR11911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R605
SonicParanoid	1	1.000	-	-		X605
TreeFam	1	0.960	-	-
	14	13.860