DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ras and impdh1a

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_005159064.1	Gene:	impdh1a / 431724	ZFINID:	ZDB-GENE-040704-15	Length:	624	Species:	Danio rerio

Alignment Length:	536	Identity:	360/536 - (67%)
Similarity:	431/536 - (80%)	Gaps:	18/536 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TGFDAELQDGLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDT 94
            ||:..|  |||:.::||..|:||||||||||||:|||.::||||:|.||:.:||:.||:||||||
Zfish    90 TGYVPE--DGLTAQQLFAIGDGLTYNDFLILPGFIDFISDEVDLTSALTRKITLKTPLISSPMDT 152

  Fly    95 VTESEMAIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKN 159
            ||||.|||||||.|||||||||||||:||.||.||||::.||:.||.||||.:|||||.||:.::
Zfish   153 VTESSMAIAMALMGGIGIIHHNCTPEFQANEVRKVKKFEQGFITDPVVMSPRHTVGDVFEAKVRH 217

  Fly   160 GFTGYPVTENGKLGGKLLGMVTSRDIDF-RENQPEVLLADIMT--TELVTAPNGINLPTANAILE 221
            ||:|.||||.||:|.||:|:|||||||| .|...:..|.:.||  .:||.||.|:.|..||.||:
Zfish   218 GFSGIPVTETGKMGSKLVGIVTSRDIDFLSEKDYDRPLEESMTKREDLVVAPAGVTLKEANDILQ 282

  Fly   222 KSKKGKLPIVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKARLALLVANG 286
            :||||||||||.:.||||:||||||||.|.||.|||||.||||.|||||||.:||.||.||:..|
Zfish   283 RSKKGKLPIVNDSDELVAIIARTDLKKNRDYPLASKDSRKQLLCGAAIGTREDDKYRLDLLMQAG 347

  Fly   287 VDVIILDSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICI 351
            ||||:|||||||||:|:.||.|||:.||||||:||||||.||||||||||||.||||||.|||||
Zfish   348 VDVIVLDSSQGNSVFQISMINYIKQKYPELQVVGGNVVTAAQAKNLIDAGVDALRVGMGCGSICI 412

  Fly   352 TQEVMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGASAVMMGSLLAGTSEAP 416
            ||||||||.||.|:||:|:.|||:||||||||||||::||:|||:|||||.||||||||.|:|||
Zfish   413 TQEVMACGRPQGTSVYKVAEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAP 477

  Fly   417 GEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVDKGSVLRYLP 481
            ||||||||||||||||||||:|||:.:   ::..||: :|.||:|||||||||:.||||:.:::|
Zfish   478 GEYFFSDGVRLKKYRGMGSLDAMEKNN---SSQKRYF-SEGDKVKVAQGVSGSVQDKGSIHKFVP 538

  Fly   482 YLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLFSYEKRLFXHTTMAATE 546
            ||..|:||.||||||.|::.||.|:|:|:|:|.|||.|||:||.||||.||....|  |.....|
Zfish   539 YLIAGIQHGCQDIGAKSLSILRSMMYSGELKFEKRTMSAQVEGGVHGLHSYSFLPF--TRNGYIE 601

  Fly   547 TGSGG-------VPAP 555
            .||.|       ||:|
Zfish   602 PGSRGHPRAGPNVPSP 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	347/497 (70%)
impdh1a	XP_005159064.1	PTZ00314	94..590	CDD:240355	348/501 (69%)
		IMPDH	109..573	CDD:238223	328/467 (70%)
		CBS_pair_IMPDH_2	195..310	CDD:239975	69/114 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581397
Domainoid	1	1.000	666	1.000	Domainoid score	I144
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68096
Inparanoid	1	1.050	695	1.000	Inparanoid score	I660
OMA	1	1.010	-	-		QHG62889
OrthoDB	1	1.010	-	-		D281746at33208
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm25939
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	O	PTHR11911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R605
SonicParanoid	1	1.000	-	-		X605
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900