DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ras and Impdh1

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_038963700.1	Gene:	Impdh1 / 362329	RGDID:	1311108	Length:	626	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	353/511 - (69%)
Similarity:	424/511 - (82%)	Gaps:	9/511 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TGFDAELQDGLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDT 94
            ||:..|  |||:.::||.|.:||||||||||||:|||.|:||||:|.||:.:||:.||:||||||
  Rat   122 TGYVPE--DGLTAQQLFANADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDT 184

  Fly    95 VTESEMAIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKN 159
            |||::|||||||.||||.||||||||:||.||.||||::.||:.||.|:||::||||||||:.::
  Rat   185 VTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIQH 249

  Fly   160 GFTGYPVTENGKLGGKLLGMVTSRDIDF-RENQPEVLLADIMT--TELVTAPNGINLPTANAILE 221
            ||:|.|:|..|.:|.||:|:|||||||| .|.....||:::||  .|||.||.|:.|..||.||:
  Rat   250 GFSGIPITATGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQ 314

  Fly   222 KSKKGKLPIVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKARLALLVANG 286
            :||||||||||...||||:||||||||.|.||.|||||:||||.|||:|||.:||.||.||...|
  Rat   315 RSKKGKLPIVNDQDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLLTQAG 379

  Fly   287 VDVIILDSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICI 351
            .|||:|||||||||||:.|:.|||:.||.||||||||||.|||||||||||||||||||.|||||
  Rat   380 ADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICI 444

  Fly   352 TQEVMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGASAVMMGSLLAGTSEAP 416
            ||||||||.||.||||:|:.|||:||||||||||||::||:|||:|||||.||||||||.|:|||
  Rat   445 TQEVMACGRPQGTAVYKVAEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAP 509

  Fly   417 GEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVDKGSVLRYLP 481
            ||||||||||||||||||||:|||    |.::..:.|.:|.||:|:||||||||.||||:.:::|
  Rat   510 GEYFFSDGVRLKKYRGMGSLDAME----KSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVP 570

  Fly   482 YLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLFSYEKRLF 537
            ||..|:||.||||||.|::.||.|:|:|:|:|.|||.|||:||.||||.||||||:
  Rat   571 YLIAGIQHGCQDIGAQSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	345/497 (69%)
Impdh1	XP_038963700.1	PTZ00314	126..622	CDD:240355	346/501 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341397
Domainoid	1	1.000	667	1.000	Domainoid score	I141
eggNOG	1	0.900	-	-		E1_COG0516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68096
Inparanoid	1	1.050	699	1.000	Inparanoid score	I646
OMA	1	1.010	-	-		QHG62889
OrthoDB	1	1.010	-	-		D281746at33208
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm45347
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	O	PTHR11911
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X605
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770