DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ras and impdh1b

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_005164774.1	Gene:	impdh1b / 338306	ZFINID:	ZDB-GENE-030219-206	Length:	603	Species:	Danio rerio

Alignment Length:	505	Identity:	348/505 - (68%)
Similarity:	420/505 - (83%)	Gaps:	7/505 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LQDGLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDTVTESEM 100
            ::||.:.:|||..|:|:||||||||||:||||::||||:|.|||.:||:.||:||||||||||.|
Zfish   103 VRDGHTAEELFSKGDGMTYNDFLILPGFIDFTSDEVDLTSALTKKITLKTPLISSPMDTVTESSM 167

  Fly   101 AIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKNGFTGYP 165
            ||||||.|||||||||||||:||.||.|||:::.||:.||.|:||.:||||||||:.::||:|.|
Zfish   168 AIAMALMGGIGIIHHNCTPEFQANEVRKVKRFEQGFITDPVVLSPHHTVGDVLEAKVRHGFSGIP 232

  Fly   166 VTENGKLGGKLLGMVTSRDIDF-RENQPEVLLADIMT--TELVTAPNGINLPTANAILEKSKKGK 227
            :||.||:|.||:|:|||||||| .|......|.:.||  .:||.||.|:.|..||.||::|||||
Zfish   233 ITETGKMGSKLVGIVTSRDIDFLSEKDNNKYLEEAMTKREDLVVAPAGVTLKEANDILQRSKKGK 297

  Fly   228 LPIVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKARLALLVANGVDVIIL 292
            |||||...||||:||||||||.|.||.|||||.||||.|||||||.:||.||.||..:|||:::|
Zfish   298 LPIVNDKDELVAIIARTDLKKNRDYPLASKDSRKQLLCGAAIGTREDDKYRLDLLTQSGVDMVVL 362

  Fly   293 DSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICITQEVMA 357
            ||||||||||:.||.|||:.||||||:||||||.||||||||||||.||||||.|||||||||||
Zfish   363 DSSQGNSVYQINMIHYIKQKYPELQVVGGNVVTAAQAKNLIDAGVDALRVGMGCGSICITQEVMA 427

  Fly   358 CGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGASAVMMGSLLAGTSEAPGEYFFS 422
            ||.||.|:||:|:.|||:||||||||||||::||:|||::||||.||||||||.|:|||||||||
Zfish   428 CGRPQGTSVYKVAEYARRFGVPVIADGGIQTVGHVVKALSLGASTVMMGSLLAATTEAPGEYFFS 492

  Fly   423 DGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVDKGSVLRYLPYLECGL 487
            ||||||||||||||:|||    |..:..:.|.:|.||:|||||||||:.||||:.:::|||..|:
Zfish   493 DGVRLKKYRGMGSLDAME----KNTSSQKRYFSEGDKVKVAQGVSGSVQDKGSIHKFVPYLIAGI 553

  Fly   488 QHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLFSYEKRLF 537
            ||.||||||.|::.||.|:|:|:|:|.|||.|||:||.||||.|:||||:
Zfish   554 QHGCQDIGAKSLSVLRSMMYSGELKFEKRTMSAQVEGGVHGLHSFEKRLY 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	344/497 (69%)
impdh1b	XP_005164774.1	PTZ00314	104..599	CDD:240355	344/498 (69%)
		IMPDH	118..582	CDD:238223	325/467 (70%)
		CBS_pair_IMPDH_2	204..319	CDD:239975	68/114 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581396
Domainoid	1	1.000	666	1.000	Domainoid score	I144
eggNOG	1	0.900	-	-		E1_COG0516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68096
Inparanoid	1	1.050	695	1.000	Inparanoid score	I660
OMA	1	1.010	-	-		QHG62889
OrthoDB	1	1.010	-	-		D281746at33208
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm25939
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	O	PTHR11911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R605
SonicParanoid	1	1.000	-	-		X605
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800