DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ras and impdh2

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_021333858.1	Gene:	impdh2 / 317745	ZFINID:	ZDB-GENE-030114-5	Length:	558	Species:	Danio rerio

Alignment Length:	555	Identity:	347/555 - (62%)
Similarity:	428/555 - (77%)	Gaps:	53/555 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TGFDAELQDGLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDT 94
            ||:..:  |||:.::||.:|:||||||||||||||||||::|||:|.|||.:|::.||:||||||
Zfish    10 TGYVPD--DGLTGQQLFNSGDGLTYNDFLILPGYIDFTADQVDLTSALTKQITMKTPLISSPMDT 72

  Fly    95 VTESEMAIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKN 159
            ||||.|||||||.||||.||||||||:||.||.|||:|:.||:.||.||||...|.||.:|:.::
Zfish    73 VTESGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKRYEQGFITDPVVMSPNERVRDVFQAKARH 137

  Fly   160 GFTGYPVTENGKLGGKLLGMVTSRDIDF-RENQPEVLLADIMT--TELVTAPNGINLPTANAILE 221
            ||.|.|:|:||::||:|:|:::|||||| :|::.::.|:::||  .:||.||.|:.|..||.||:
Zfish   138 GFCGIPITDNGQMGGRLVGIISSRDIDFLKESEHDLPLSEVMTKREDLVVAPAGVTLKEANEILQ 202

  Fly   222 KSKK--------------------GKLPIVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVG 266
            :|||                    |||||||:.|.|||:||||||||.|.:|.|||||.||||.|
Zfish   203 RSKKDEIYSCGGKTEFSAVITPFSGKLPIVNEEGCLVAIIARTDLKKNRDFPLASKDSRKQLLCG 267

  Fly   267 AAIGTRSEDKARLALLVANGVDVIILDSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKN 331
            |||||.::||.||.||...||||::||||||||::|:.|||||||.||.:|||||||||.|||||
Zfish   268 AAIGTHNDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKEKYPNVQVIGGNVVTAAQAKN 332

  Fly   332 LIDAGVDGLRVGMGSGSICITQE------------------------VMACGCPQATAVYQVSTY 372
            |||||.|.|||||||||||||||                        ::|||.|||||||:||.|
Zfish   333 LIDAGADALRVGMGSGSICITQEAPLSIPPGIKLHSPKTPTTVTGYSMLACGRPQATAVYKVSEY 397

  Fly   373 ARQFGVPVIADGGIQSIGHIVKAIALGASAVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLE 437
            ||:||||||||||||::|||.||:|||||.||||||||.|||||||||||||:|||||||||||:
Zfish   398 ARRFGVPVIADGGIQTVGHIAKALALGASTVMMGSLLAATSEAPGEYFFSDGIRLKKYRGMGSLD 462

  Fly   438 AMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVDKGSVLRYLPYLECGLQHSCQDIGANSINKL 502
            ||   |....:.:||: :|.||:||||||||::.||||:.:::|||..|:|||||||||.|:.:|
Zfish   463 AM---DKNLGSQTRYF-SESDKIKVAQGVSGAVQDKGSIHKFVPYLLVGIQHSCQDIGAKSLTQL 523

  Fly   503 RDMIYNGQLRFMKRTHSAQLEGNVHGLFSYEKRLF 537
            |.|:|:|:|||.|||.|||:||.||.|.|||||||
Zfish   524 RAMMYSGELRFEKRTMSAQMEGGVHSLHSYEKRLF 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	339/541 (63%)
impdh2	XP_021333858.1	PTZ00314	16..554	CDD:240355	339/541 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	666	1.000	Domainoid score	I144
eggNOG	1	0.900	-	-		E1_COG0516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	695	1.000	Inparanoid score	I660
OMA	1	1.010	-	-		QHG62889
OrthoDB	1	1.010	-	-		D281746at33208
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm25939
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	LDO	PTHR11911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R605
SonicParanoid	1	1.000	-	-		X605
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870