DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ras and Impdh2

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_006243813.1	Gene:	Impdh2 / 301005	RGDID:	735092	Length:	538	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	346/527 - (65%)
Similarity:	422/527 - (80%)	Gaps:	31/527 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DGLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDTVTESEMAI 102
            |||:.::||..|:||||||||||||||||||::|||:|.|||.:||:.||||||||||||:.|||
  Rat    16 DGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAI 80

  Fly   103 AMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKNGFTGYPVT 167
            ||||.||||.||||||||:||.||.|||||:.||:.||.|:||.:.|.||.||:.::||.|.|:|
  Rat    81 AMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPIT 145

  Fly   168 ENGKLGGKLLGMVTSRDIDF-RENQPEVLLADIMT--TELVTAPNGINLPTANAILEKSKKGKLP 229
            :.|::|.:|:|:::|||||| :|.:.:..|.:|||  .:||.||.|:.|..||.||::|||||||
  Rat   146 DTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLP 210

  Fly   230 IVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKARLALLVANGVDVIILDS 294
            |||::.||||:||||||||.|.||.||||:.||||.||||||..:||.||.||...||||::|||
  Rat   211 IVNESDELVAIIARTDLKKNRDYPLASKDTKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDS 275

  Fly   295 SQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICITQE----- 354
            |||||::|:.|||||||.||.||||||||||.||||||||||||.|||||||||||||||
  Rat   276 SQGNSIFQINMIKYIKEKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEAAPKI 340

  Fly   355 -------------------VMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGA 400
                               ::|||.|||||||:||.|||:||||||||||||::|||.||:||||
  Rat   341 PPDIKSHSPKCPSTVSGCYMLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGA 405

  Fly   401 SAVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQG 465
            |.||||||||.|:|||||||||||:|||||||||||:||   |...::.:||: :|.||:|||||
  Rat   406 STVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM---DKHLSSQNRYF-SEADKIKVAQG 466

  Fly   466 VSGSIVDKGSVLRYLPYLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLF 530
            |||::.||||:.:::|||..|:|||||||||.|:.::|.|:|:|:|:|.|||.|||:||.||||.
  Rat   467 VSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHGLH 531

  Fly   531 SYEKRLF 537
            |||||||
  Rat   532 SYEKRLF 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	340/521 (65%)
Impdh2	XP_006243813.1	PLN02274	15..538	CDD:215154	344/525 (66%)
		IMPDH	29..504	CDD:238223	315/478 (66%)
		CBS_pair_IMPDH_2	115..230	CDD:239975	61/114 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	667	1.000	Domainoid score	I141
eggNOG	1	0.900	-	-		E1_COG0516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	699	1.000	Inparanoid score	I646
OMA	1	1.010	-	-		QHG62889
OrthoDB	1	1.010	-	-		D281746at33208
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm45347
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	LDO	PTHR11911
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X605
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840