DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ras and Impdh2

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_001365850.1	Gene:	Impdh2 / 23918	MGIID:	109367	Length:	538	Species:	Mus musculus

Alignment Length:	527	Identity:	345/527 - (65%)
Similarity:	420/527 - (79%)	Gaps:	31/527 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DGLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDTVTESEMAI 102
            |||:.::||..|:||||||||||||||||||::|||:|.|||.:||:.||||||||||||:.|||
Mouse    16 DGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAI 80

  Fly   103 AMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKNGFTGYPVT 167
            ||||.||||.||||||||:||.||.|||||:.||:.||.|:||.:.|.||.||:.::||.|.|:|
Mouse    81 AMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPIT 145

  Fly   168 ENGKLGGKLLGMVTSRDIDF-RENQPEVLLADIMT--TELVTAPNGINLPTANAILEKSKKGKLP 229
            :.|::|.:|:|:::|||||| :|.:.:..|.:|||  .:||.||.|:.|..||.||::|||||||
Mouse   146 DTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLP 210

  Fly   230 IVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKARLALLVANGVDVIILDS 294
            |||:..||||:||||||||.|.||.||||:.||||.||||||..:||.||.||...||||::|||
Mouse   211 IVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDS 275

  Fly   295 SQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICITQE----- 354
            |||||::|:.|||||||.||.||||||||||.||||||||||||.|||||||||||||||
Mouse   276 SQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEAAPKI 340

  Fly   355 -------------------VMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGA 400
                               ::|||.|||||||:||.|||:||||||||||||::|||.||:||||
Mouse   341 PPDIKSHSPKCPSTVSGCYMLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGA 405

  Fly   401 SAVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQG 465
            |.||||||||.|:|||||||||||:|||||||||||:||   |...::.:||: :|.||:|||||
Mouse   406 STVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM---DKHLSSQNRYF-SEADKIKVAQG 466

  Fly   466 VSGSIVDKGSVLRYLPYLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLF 530
            |||::.||||:.:::|||..|:|||||||||.|:.::|.|:|:|:|:|.|||.|||:||.||.|.
Mouse   467 VSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLH 531

  Fly   531 SYEKRLF 537
            |||||||
Mouse   532 SYEKRLF 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	339/521 (65%)
Impdh2	NP_001365850.1	PTZ00314	16..534	CDD:240355	339/521 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	668	1.000	Domainoid score	I152
eggNOG	1	0.900	-	-		E1_COG0516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	700	1.000	Inparanoid score	I671
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62889
OrthoDB	1	1.010	-	-		D281746at33208
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm43277
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	LDO	PTHR11911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R605
SonicParanoid	1	1.000	-	-		X605
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870