DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ras and Impdh1

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_006505128.2	Gene:	Impdh1 / 23917	MGIID:	96567	Length:	604	Species:	Mus musculus

Alignment Length:	525	Identity:	355/525 - (67%)
Similarity:	425/525 - (80%)	Gaps:	11/525 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TGFDAELQDGLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDT 94
            ||:..|  |||:.::||.|.:||||||||||||:|||.|:||||:|.||:.:||:.||:||||||
Mouse    68 TGYVPE--DGLTAQQLFANADGLTYNDFLILPGFIDFIADEVDLTSALTRKITLKTPLISSPMDT 130

  Fly    95 VTESEMAIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKN 159
            |||::|||||||.||||.||||||||:||.||.||||::.||:.||.|:||::||||||||:.::
Mouse   131 VTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKFEQGFITDPVVLSPSHTVGDVLEAKIQH 195

  Fly   160 GFTGYPVTENGKLGGKLLGMVTSRDIDF-RENQPEVLLADIMT--TELVTAPNGINLPTANAILE 221
            ||:|.|:|..|.:|.||:|:|||||||| .|.....||:::||  .|||.||.|:.|..||.||:
Mouse   196 GFSGIPITATGTMGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRVELVVAPAGVTLKEANEILQ 260

  Fly   222 KSKKGKLPIVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRSEDKARLALLVANG 286
            :||||||||||...||||:||||||||.|.||.|||||:||||.|||:|||.:||.||.||...|
Mouse   261 RSKKGKLPIVNDQDELVAIIARTDLKKNRDYPLASKDSHKQLLCGAAVGTREDDKYRLDLLTQAG 325

  Fly   287 VDVIILDSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICI 351
            .|||:|||||||||||:.|:.|||:.||.||||||||||.|||||||||||||||||||.|||||
Mouse   326 ADVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICI 390

  Fly   352 TQEVMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGASAVMMGSLLAGTSEAP 416
            ||||||||.||.||||:|:.|||:||||||||||||::||:|||:|||||.||||||||.|:|||
Mouse   391 TQEVMACGRPQGTAVYKVAEYARRFGVPVIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAP 455

  Fly   417 GEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVDKGSVLRYLP 481
            ||||||||||||||||||||:|||    |.::..:.|.:|.||:|:||||||||.||||:.:::|
Mouse   456 GEYFFSDGVRLKKYRGMGSLDAME----KSSSSQKRYFSEGDKVKIAQGVSGSIQDKGSIQKFVP 516

  Fly   482 YLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLFSYEKRLFXHTTMAATE 546
            ||..|:||.||||||.|::.||.|:|:|:|:|.|||.|||:||.||||.||....|  |....||
Mouse   517 YLIAGIQHGCQDIGAQSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYTFLPF--TRSGCTE 579

  Fly   547 TGSGG 551
            ...||
Mouse   580 DSGGG 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	345/497 (69%)
Impdh1	XP_006505128.2	PTZ00314	72..568	CDD:240355	346/501 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837675
Domainoid	1	1.000	668	1.000	Domainoid score	I152
eggNOG	1	0.900	-	-		E1_COG0516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68096
Inparanoid	1	1.050	700	1.000	Inparanoid score	I671
Isobase	1	0.950	-	0	Normalized mean entropy	S236
OMA	1	1.010	-	-		QHG62889
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm43277
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	O	PTHR11911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R605
SonicParanoid	1	1.000	-	-		X605
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740