Protein Alignment ras and T22D1.3

DIOPT Version :9

• Sequence 1: NP_001356940.1
• Gene: ras / 43873
• FlyBaseID: FBgn0003204
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_001023395.1
• Gene: T22D1.3 / 177457
• WormBaseID: WBGene00020682
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 525
• Identity: 283/525 - (53%)
• Similarity: 369/525 - (70%)
• Gaps: 23/525 - (4%)

  Fly    33 DAELQDGLSCKELFQNGEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPLVSSPMDTVTE 97
            |..|.||.:..|:..:..|||||||.||||:|:|...:|.|.:.:||.|.::|||||||||||||
 Worm    13 DNSLTDGETVHEMMAHKAGLTYNDFNILPGFINFGVHDVSLETNITKDLKIKAPLVSSPMDTVTE 77

  Fly    98 SEMAIAMALCGGIGIIHHNC-TPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDVLEARRKNGF 161
            |.|||.|||.|||||||.|. .||.||.||.|||::|.|::..|..:|..:|..|:::.::|.|:
 Worm    78 SGMAIVMALYGGIGIIHGNFPKPEDQAAEVLKVKRFKQGYVMQPHCLSRDSTAFDMIQIKKKYGY 142

  Fly   162 TGYPVTENGKLGGKLLGMVTSRDIDF-------RENQPEVLLADIMTTELVT----APNGINLPT 215
            ||.||||:|::|.||:|||||||.||       ::..|.....|:..|..:|    :.:.::|..
 Worm   143 TGAPVTEDGRVGSKLIGMVTSRDFDFITMDVAGQKGTPISDTNDVTPTTPITRIMVSVDQLHLGH 207

  Fly   216 ANAILEKSKK-------GKLPIVNQAGELVAMIARTDLKKARSYPNASKDSNKQLLVGAAIGTRS 273
            .|...|.|:|       |||||||..|||.|::.|:||.|||.||.||.||..|||.|||:.||.
 Worm   208 INDAPELSQKKLKEHRLGKLPIVNDNGELCALLCRSDLLKARDYPMASYDSKGQLLCGAAVNTRG 272

  Fly   274 EDKARLALLVANGVDVIILDSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVD 338
            |.:..:..:|..||||:|:|||.|:|.||:.|::||||.:|.:|||.||||||||||.|||.|.|
 Worm   273 ESQYTVDRVVEAGVDVLIIDSSNGSSTYQISMLRYIKEKHPHVQVIAGNVVTRAQAKLLIDQGAD 337

  Fly   339 GLRVGMGSGSICITQEVMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGASAV 403
            |||:|||||||||||:|||.|..|.||||.|:.||.|.|:|::|||||:.:|:|.|||:||||||
 Worm   338 GLRIGMGSGSICITQDVMAVGRAQGTAVYDVARYANQRGIPIVADGGIRDVGYITKAISLGASAV 402

  Fly   404 MMGSLLAGTSEAPGEYFFS-DGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVS 467
            |||.|||.|:|||||||:. .|||:|||||||||:|||   |..::..||:..|.|::|||||||
 Worm   403 MMGGLLAATTEAPGEYFWGPGGVRVKKYRGMGSLDAME---AHASSQDRYFTAESDQIKVAQGVS 464

  Fly   468 GSIVDKGSVLRYLPYLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLFSY 532
            .::.|:||..:::|||..|:||..||||..|:...|:.:.||.::|.:|:.:|||||.||.|.|:
 Worm   465 ATMKDRGSCHKFIPYLIRGVQHGMQDIGVRSLRDFREKVDNGIVKFERRSTNAQLEGGVHSLHSF 529

  Fly   533 EKRLF 537
            ||||:
 Worm   530 EKRLY 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	277/514 (54%)
T22D1.3	NP_001023395.1	PTZ00314	16..530	CDD:240355	278/516 (54%)
		IMPDH	31..513	CDD:238223	264/484 (55%)
		CBS_pair_IMPDH_2	118..248	CDD:239975	48/129 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	500	1.000	Domainoid score	I173
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68096
Inparanoid	1	1.050	522	1.000	Inparanoid score	I679
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62889
OrthoDB	1	1.010	-	-		D281746at33208
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		oto19057
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	LDO	PTHR11911
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R605
SonicParanoid	1	1.000	-	-		X605
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.010