DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ras and AgaP_AGAP011133

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	XP_309514.2	Gene:	AgaP_AGAP011133 / 1270793	VectorBaseID:	AGAP011133	Length:	538	Species:	Anopheles gambiae

Alignment Length:	538	Identity:	420/538 - (78%)
Similarity:	465/538 - (86%)	Gaps:	2/538 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESTTKVKVNGFVESTSSSAAPAIQTKSTTGFDAELQDGLSCKELFQNGEGLTYNDFLILPGYIDF 66
            |:..:..|.|...:.::...||.......|....|||||||:|||:..:|||||||:||||||||
Mosquito     1 EACVRACVFGVWPTGNAWLIPAGLRTMENGTSNNLQDGLSCEELFRKSDGLTYNDFIILPGYIDF 65

  Fly    67 TAEEVDLSSPLTKSLTLRAPLVSSPMDTVTESEMAIAMALCGGIGIIHHNCTPEYQALEVHKVKK 131
            |||||||||||||.:.|:|||||||||||||:||||:||||||||||||||||||||.|||||||
Mosquito    66 TAEEVDLSSPLTKKIMLKAPLVSSPMDTVTEAEMAISMALCGGIGIIHHNCTPEYQANEVHKVKK 130

  Fly   132 YKHGFMRDPSVMSPTNTVGDVLEARRKNGFTGYPVTENGKLGGKLLGMVTSRDIDFRENQPEVLL 196
            |||||:|||.||.|.|||.|||||:|||||||||:|||||:|.:|:|:||||||||||:..::.|
Mosquito   131 YKHGFIRDPLVMGPENTVADVLEAKRKNGFTGYPITENGKIGTRLVGIVTSRDIDFREHDVDIKL 195

  Fly   197 ADIMT--TELVTAPNGINLPTANAILEKSKKGKLPIVNQAGELVAMIARTDLKKARSYPNASKDS 259
            .||||  .:|:|||||:.|..||.|:||||||||||||:.|||||:||||||||.|:||||.|||
Mosquito   196 KDIMTKLEDLITAPNGVTLQEANNIMEKSKKGKLPIVNKTGELVALIARTDLKKGRTYPNALKDS 260

  Fly   260 NKQLLVGAAIGTRSEDKARLALLVANGVDVIILDSSQGNSVYQVEMIKYIKETYPELQVIGGNVV 324
            |||||||||||||.|||.||.||..||||||:||||||||:||:.|||||||.||.||||.||||
Mosquito   261 NKQLLVGAAIGTRDEDKERLELLYQNGVDVIVLDSSQGNSLYQINMIKYIKEKYPSLQVIAGNVV 325

  Fly   325 TRAQAKNLIDAGVDGLRVGMGSGSICITQEVMACGCPQATAVYQVSTYARQFGVPVIADGGIQSI 389
            ||.||.|||.||.|.||||||||||||||||||||||||||||||...|||:|||||||||||||
Mosquito   326 TRQQAYNLITAGCDALRVGMGSGSICITQEVMACGCPQATAVYQVCNLARQYGVPVIADGGIQSI 390

  Fly   390 GHIVKAIALGASAVMMGSLLAGTSEAPGEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYH 454
            ||||||::||||||||||||||||||||||:|||||||||||||||||||||.|.||:|.|||||
Mosquito   391 GHIVKALSLGASAVMMGSLLAGTSEAPGEYYFSDGVRLKKYRGMGSLEAMERKDGKGSASSRYYH 455

  Fly   455 NEMDKMKVAQGVSGSIVDKGSVLRYLPYLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHS 519
            .|::||:||||||||||||||:||::|||.||||||||||||.||..||.|||||:|||||||||
Mosquito   456 TEIEKMRVAQGVSGSIVDKGSILRFVPYLLCGLQHSCQDIGARSIANLRKMIYNGELRFMKRTHS 520

  Fly   520 AQLEGNVHGLFSYEKRLF 537
            ||||||||||||||||||
Mosquito   521 AQLEGNVHGLFSYEKRLF 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	406/496 (82%)
AgaP_AGAP011133	XP_309514.2	PTZ00314	37..534	CDD:240355	406/496 (82%)
		IMPDH	50..517	CDD:238223	381/466 (82%)
		CBS_pair_IMPDH_2	136..249	CDD:239975	79/112 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	792	1.000	Domainoid score	I313
eggNOG	1	0.900	-	-		E1_COG0516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68096
Inparanoid	1	1.050	836	1.000	Inparanoid score	I1333
OMA	1	1.010	-	-		QHG62889
OrthoDB	1	1.010	-	-		D281746at33208
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm50346
Panther	1	1.100	-	-	LDO	PTHR11911
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X605
TreeFam	1	0.960	-	-
	13	12.940