Protein Alignment ras and CLCN6

DIOPT Version :9

• Sequence 1: NP_001356940.1
• Gene: ras / 43873
• FlyBaseID: FBgn0003204
• Length: 590
• Species: Drosophila melanogaster
• Sequence 2: NP_001277.2
• Gene: CLCN6 / 1185
• HGNCID: 2024
• Length: 869
• Species: Homo sapiens
• Alignment Length: 195
• Identity: 41/195 - (21%)
• Similarity: 66/195 - (33%)
• Gaps: 70/195 - (35%)

  Fly   319 IGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICITQEVMACGCPQATAVYQVSTYARQFG------ 377
            |||.:.:..:..:..:.|              :|.:|:.|.. .||..........|||
Human   258 IGGTLFSLEEGSSFWNQG--------------LTWKVLFCSM-SATFTLNFFRSGIQFGSWGSFQ 307

  Fly   378 VPVIADGGIQSIG-----------HIVKAIALGASAVM--MGSLLAGTSEAPGEYFFSDGVRLKK 429
            :|     |:.:.|           |:..|:.||...||  :|.||..|       |.....||.|
Human   308 LP-----GLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGAT-------FNCLNKRLAK 360

  Fly   430 Y------------RGMGSL------------EAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSI 470
            |            |.:.||            .:|..|:.:..:.|....|:..:::|.:.|:.||
Human   361 YRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSI 425

  Fly   471  470
            Human   426  425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	41/195 (21%)
CLCN6	NP_001277.2	ClC_6_like	49..588	CDD:239657	41/195 (21%)
		Selectivity filter part_1. /evidence=ECO:0000250	156..160
		Selectivity filter part_2. /evidence=ECO:0000250	198..202
		Selectivity filter part_3. /evidence=ECO:0000250	487..491
		CBS_pair_voltage-gated_CLC_euk_bac	600..856	CDD:341367
		CBS repeat	606..806	CDD:341367
		CBS repeat	812..855	CDD:341367

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910