DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and ADAMTSL2

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_011517543.2	Gene:	ADAMTSL2 / 9719	HGNCID:	14631	Length:	1021	Species:	Homo sapiens

Alignment Length:	955	Identity:	219/955 - (22%)
Similarity:	326/955 - (34%)	Gaps:	333/955 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVAFIVLASIHDSQSRFPGLRQKRQYGANMYLPESSVTPGGEGNDPDEWTP-WSSPSDCS--RTC 73
            |:...|:|....|....|.||      |.::||..|.: ...|..|....| .:|.::|.  |..
Human   123 LLVLAVVAGDTVSTGSTPSLR------ACIFLPGGSPS-RAPGTGPARARPSGTSSAECRSVRRT 180

  Fly    74 GG-----GVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDC---PEEESDFRAQQCSRFDRQQF 130
            ||     ..|..|..|........::|:..:......|...|   |...|.
Human   181 GGASARSSASPSTPTCTTGGRTSGSLCTRMTMSTSPANRVTCTVPPWTASG-------------- 231

  Fly   131 DGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLG 195
                ..|.|...|.....|.|                :|..|.:.           |:|||.:|.
Human   232 ----SSWSPPATAHPASSLTC----------------EGFACLEN-----------PIGCDGVLF 265

  Fly   196 SDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHS 260
            |....|||..|.||||:|..:.......:...||:.:..:|.||.:|:|.|...|::.||..:.:
Human   266 STHTLDKCGICQGDGSSCTHVTGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEA 330

  Fly   261 GHYYLNGDWRIDFP-------------RPMFFANSW------------------WN--------- 285
            |:|:.||::::|.|             |||....:.                  ||
Human   331 GYYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSIT 395

  Fly   286 ---------YQRKP---------------------MGF----------AAPDQL----------- 299
                     ::.:|                     |||          |:.::|
Human   396 FEYTLLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQASSERLGLDNRLFGHPG 460

  Fly   300 -----------------------TCSGP-----------------------------ISESLFIV 312
                                   .|.||                             .|:..|..
Human   461 LDMELGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSA 525

  Fly   313 MLVQE---------KNISL-----------------------DYEY------------------- 326
            ..:.:         |:.:|                       |||.
Human   526 NAISDQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSD 590

  Fly   327 ------------SIPESL-------SH-------------SQQDTHTWTHHQFNACSASCGGGSQ 359
                        ::..||       :|             |..|.:.|.......|||:|..|..
Human   591 RVANSSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVM 655

  Fly   360 SRKVTCNNRITLAEVNPSLCD--QKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSI 422
            |....| .|....||:.|.||  .:.:||.|...|.| |.|.|....||:||:.|| :|:|.|.:
Human   656 SAYAMC-VRYDGVEVDDSYCDALTRPEPVHEFCAGRE-CQPRWETSSWSECSRTCG-EGYQFRVV 717

  Fly   423 TCERISSSG-EHTVEEDAVCLKEVGNKPATKQECNRDVKNC-PKYHLGPWTPCDKLCGD-GKQTR 484
            .|.::.|.| :.:|..| :|......:|..::.|....  | |::.:..|:.|...||: ...||
Human   718 RCWKMLSPGFDSSVYSD-LCEAAEAVRPEERKTCRNPA--CGPQWEMSEWSECTAKCGERSVVTR 779

  Fly   485 KVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEGVDWIISQWSGCN-ACGQNTETRTAICG 548
            .:.|..:|   |...|     ..:|..||:|...||:. .|.:|.|..|: :|||....|...|.
Human   780 DIRCSEDE---KLCDP-----NTRPVGEKNCTGPPCDR-QWTVSDWGPCSGSCGQGRTIRHVYCK 835

  Fly   549 NKEGKVYPEEFCEPEV-PTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEF-DGKTV 611
            ..:|:|.||..|:.|. |....||....|.|.|.:.:|.:|:..||:|||.|:|:|.|. :||..
Human   836 TSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQ 900

  Fly   612 TPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSV-N 675
            |.:..:  |....||..|..|  .|:.| .:|:|.||.:|:|.||.|.|:|:|.|. .||..| .
Human   901 TRSGPE--CGLAKKPPEESTC--FERPC-FKWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRG 959

  Fly   676 CDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEEDC-DEDG 719
            ||     ||.:....:||   ::.|.     |.|..::.| |:.|
Human   960 CD-----PLVKPVGRQAC---DLQPC-----PTEPPDDSCQDQPG 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	12/61 (20%)
		ADAM_spacer1	214..329	CDD:283607	38/320 (12%)
		TSP1	468..521	CDD:214559	15/53 (28%)
		TSP_1	645..693	CDD:278517	19/48 (40%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
ADAMTSL2	XP_011517543.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810