DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and ADAMTS2

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_055059.2	Gene:	ADAMTS2 / 9509	HGNCID:	218	Length:	1211	Species:	Homo sapiens

Alignment Length:	780	Identity:	210/780 - (26%)
Similarity:	321/780 - (41%)	Gaps:	216/780 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PD------EWTPWSSPSDCSRTCGGGVSYQTRECLRRDD----RGEAVCSGGSRRYFSCNTQDCP 111
            ||      .|..||....||||||.||.::||:|   |:    .|...|||.:..:..|:.||||
Human   555 PDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQC---DNPHPANGGRTCSGLAYDFQLCSRQDCP 616

  Fly   112 EEESDFRAQQCSRFDRQQFDGVFYE-------WVP--YTNAPNPCELNCMPKGERFYYRQREKVV 167
            :..:|||.:||.::|      :::|       |:|  :.:|...|.|.|..:........:..|.
Human   617 DSLADFREEQCRQWD------LYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVH 675

  Fly   168 DGTRCNDKD-LDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYND 231
            |||||:.|| ..:||.|:|..||||.::||..:||||..||||.|.||.::.|.|......||..
Human   676 DGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIK 740

  Fly   232 LLLLPEGATNIRIEETVPSSNYLACRN-HSGHYYLNGDWRIDFPRPMFFA-NSWWNYQRKPMGFA 294
            :..:|.||.::.|:|...:|::||.:| .:|.:.||.:..:|.....|.| ...|.|:.:.
Human   741 MFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDED---- 801

  Fly   295 APDQLTCSGPISESLFIVML-VQEKNISLDYEYSIPE-SLSHS-----QQDT--HTWTHHQFNAC 350
            ..:.|...||:..::.:::: |.:..:||.|:|.|.| ||:..     ::|:  :.|...:::.|
Human   802 GRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPC 866

  Fly   351 SASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKP-VEEQACGTEPCA-PHWVEGEWSKCSKGCG 413
            |..||||||..|..|..|:....|:...|...||| ...:||..:.|: |.||.|||..||:.||
Human   867 SKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCG 931

  Fly   414 SDGFQNRSITCERISSSGEHTVEEDAVCLKEVGN-KPATKQECNRDVKNCP-KYHLGPWTPCDKL 476
            ..|.|.||:.|  |....::|..  :|..|...: :|.:::.|:|::  || ::..|||:.|...
Human   932 RTGMQVRSVRC--IQPLHDNTTR--SVHAKHCNDARPESRRACSREL--CPGRWRAGPWSQCSVT 990

  Fly   477 CGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEGVDWIISQWSGCNACGQNTE 541
            ||:|.|.|.|.|...::..      ..|.||:|||.::|.|.||
Human   991 CGNGTQERPVLCRTADDSF------GICQEERPETARTCRLGPC--------------------- 1028

  Fly   542 TRTAICGNKEGKVYPEEFCEPE-----VPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIV 601
                          |....:|.     |..||||
Human  1029 --------------PRNISDPSKKSYVVQWLSRP------------------------------- 1048

  Fly   602 ICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKV----------C--PGEWFTGPWGK-CSK 653
                         |.||...|.:   |:..|:|::.:          |  ||      :.| |.|
Human  1049 -------------DPDSPIRKIS---SKGHCQGDKSIFCRMEVLSRYCSIPG------YNKLCCK 1091

  Fly   654 PCGGGERVREVLCLSNGTKSVNCDEEKVEPLSEKCNS-----------EACTEDEILPLTSTDKP 707
            .|.          |.|...:|   |.::||...|.|.           ....|....|.|..:.|
Human  1092 SCN----------LYNNLTNV---EGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVP 1143

  Fly   708 IEDDEEDCDEDGIELIS-------DGLSDDEKSEDVIDLEGTAKTETTPEAEDLMQSDSPTPYDE 765
            :.....:..||..|..:       .||.|:.:..::|...                   |:||::
Human  1144 LNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRR-------------------PSPYEK 1189

Fly 766 765
Human 1190 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	22/54 (41%)
		ADAM_spacer1	214..329	CDD:283607	30/117 (26%)
		TSP1	468..521	CDD:214559	20/52 (38%)
		TSP_1	645..693	CDD:278517	12/59 (20%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
ADAMTS2	NP_055059.2	Pep_M12B_propep	100..211	CDD:279848
		ZnMc_ADAMTS_like	266..467	CDD:239801
		Reprolysin	268..470	CDD:279729
		TSP1	564..616	CDD:214559	22/54 (41%)
		Cell attachment site. /evidence=ECO:0000255	691..693		0/1 (0%)
		Spacer	723..851		34/131 (26%)
		ADAM_spacer1	723..837	CDD:283607	30/117 (26%)
		TSP1	863..914	CDD:214559	18/50 (36%)
		TSP1	917..976	CDD:214559	21/64 (33%)
		TSP1	982..1029	CDD:214559	21/87 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1191		6/39 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810