DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and CD22

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001762.2	Gene:	CD22 / 933	HGNCID:	1643	Length:	847	Species:	Homo sapiens

Alignment Length:	681	Identity:	133/681 - (19%)
Similarity:	204/681 - (29%)	Gaps:	240/681 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2330 PSVHERRWYYDDEAGNC---VSFIYAGCSGNQNNFRSFEACTNQCRPEPNKQDNEIGQNPCDTFD 2391
            ||..:|..:..|:..||   :..::...|| |...| .|:.|.:.....:...:|....|.....
Human    86 PSEQKRVQFLGDKNKNCTLSIHPVHLNDSG-QLGLR-MESKTEKWMERIHLNVSERPFPPHIQLP 148

  Fly  2392 AECQELRCPYGVRRVAARSQPECTQCICENPCEGYSCP-----EG---QQCAI--------DVAS 2440
            .|.||             ||.....|:....|.||...     ||   :|.|:        .|.:
Human   149 PEIQE-------------SQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFT 200

  Fly  2441 SDDRQFAP---------VCR--------------------------------DIYKPGECPALSA 2464
            ..:.:|:|         .|:                                .|.:.|:...::.
Human   201 RSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTC 265

  Fly  2465 NASGCARECYTDADCRGD--------------NKCCSDGCGQLCVHPARPTQPPRTQAPVVSYPG 2515
            ..|....| ||......|              .:...|..|:.|...:....|.|::...:
Human   266 EVSSSNPE-YTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFL---- 325

  Fly  2516 DARAALEPKEAHELDVQTAIGGIAVLRCFATGNPAP-NITW--SLKNLVINTNKGRYVLTANGDL 2577
            ..:.|.||.....|......|......|.:..||.| |.||  :.|.:     :||    ....:
Human   326 QVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEM-----QGR----TEEKV 381

  Fly  2578 TIVQVRQTDDGTYVCVASNGLGEPVR---REVALQ-----VTEPVSQPAYIYGDKNVTQIVELN- 2633
            .|.::.....|||.|||.|.||...|   .|:.:|     ||..:..|..|.....||.....|
Human   382 HIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNS 446

  Fly  2634 -RPAVIRC---PAGGFPEP--------HVSW---------------W------------------ 2653
             .|:|.|.   |.|.:.||        :|.|               |
Human   447 SNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVR 511

  Fly  2654 -------------------------RNGQMFGLKN-NLMARDYSLVFNSIQLSDLGLYTCEVYNQ 2692
                                     :..|.|..|| .|:.::..|.|:||...|.|.|:|.|.|
Human   512 KIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNN- 575

  Fly  2693 RRPVSLRVTLKAVGPVRPLSPEEEQYMQYVLNPATRPVTQRPSYPYRPTRPAYVPEPTVNVHAVL 2757
                       ::|                 ..|::..|....|..|..|              :
Human   576 -----------SIG-----------------QTASKAWTLEVLYAPRRLR--------------V 598

  Fly  2758 ALEPKNSYTPGSTIVMSC-SVQGYPEPNVTWIKDDVPLYNNERVQITYQPHRLVLSDVTSADSGK 2821
            ::.|.:....|.:..::| |....|..:.||..     :||:  .:.|...:|.|..|....||.
Human   599 SMSPGDQVMEGKSATLTCESDANPPVSHYTWFD-----WNNQ--SLPYHSQKLRLEPVKVQHSGA 656

  Fly  2822 YTCRASNAYTYANGEANVSIQSVVPVSPECV 2852
            |.|:.:|  :...|.:.:|..:|. .|||.:
Human   657 YWCQGTN--SVGKGRSPLSTLTVY-YSPETI 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057	12/44 (27%)
		WAP	2457..2497	CDD:278522	9/53 (17%)
		Ig	2521..2610	CDD:299845	27/99 (27%)
		IG_like	2530..2610	CDD:214653	24/90 (27%)
		IG_like	2627..2703	CDD:214653	27/147 (18%)
		Ig	2636..2701	CDD:143165	24/134 (18%)
		IG_like	2766..2841	CDD:214653	18/75 (24%)
		Ig	2768..2830	CDD:299845	17/62 (27%)
		PLAC	2851..2883	CDD:285849	0/2 (0%)
CD22	NP_001762.2	Ig	24..122	CDD:299845	10/37 (27%)
		C2-set_2	143..228	CDD:285423	18/97 (19%)
		I-set	242..327	CDD:254352	12/89 (13%)
		IGc2	257..316	CDD:197706	9/59 (15%)
		Ig_3	335..400	CDD:290638	19/73 (26%)
		IG_like	343..415	CDD:214653	23/80 (29%)
		IG_like	433..501	CDD:214653	13/67 (19%)
		I-set	510..589	CDD:254352	18/107 (17%)
		IGc2	521..578	CDD:197706	15/68 (22%)
		IG_like	606..677	CDD:214653	19/79 (24%)
		IGc2	608..666	CDD:197706	17/66 (26%)
		ITIM motif 1	760..765
		ITIM motif 2	794..799
		ITIM motif 3	820..825
		ITIM motif 4	840..845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900