DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppn and PAPLN

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_047287828.1 Gene:PAPLN / 89932 HGNCID:19262 Length:1305 Species:Homo sapiens


Alignment Length:2916 Identity:507/2916 - (17%)
Similarity:695/2916 - (23%) Gaps:1672/2916 - (57%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PGLRQKRQYG-----ANMYLPESSVTPG------GEGND----------PDEWTPWSSPSDCSRT 72
            |.|....:.|     |::.....|:||.      |.|:.          |.:..|..||...:.|
Human     6 PALNPNYRVGRALSPASLEYQHGSLTPTWGIYGVGSGDTLSPCCSHWRVPQKLGPAESPRTGAGT 70

  Fly    73 CGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEW 137
            .|.|..:......|||  |.:.|.|.:|.:.||.|:.||:...||||:||:.||..:|.|..|.|
Human    71 LGLGQVFPVLWSRRRD--GGSSCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYRW 133

  Fly   138 VPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDK 202
            :||.:|||.|||||:||||.|||:.||.|||||.|.....||||:|.|..||||..|.|..:|||
Human   134 LPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDK 198

  Fly   203 CRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNG 267
            |.:|||||:||..:..|....||:.|||.:|::|.|||:|.|:|...|.|:||.:|..|.|||||
Human   199 CLRCGGDGTTCYPVAGTFDANDLSRGYNQILIVPMGATSILIDEAAASRNFLAVKNVRGEYYLNG 263

  Fly   268 DWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSIPESL 332
            .|.|:..|.:..|::..:|:|...|..||::|...||.||.|.|.::.||.|..:.|||.:|   
Human   264 HWTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLP--- 325

  Fly   333 SHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITL-AEVNPS-LCDQKSKPVEEQACGTEP 395
            ........:|:|..::.|||.||||.|||.|.|    |: .|..|. :|.::.:|.:.::|...|
Human   326 LRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFC----TIDHEAYPDHMCQRQPRPADRRSCNLHP 386

  Fly   396 CAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVK 460
            |                                                    |.||        
Human   387 C----------------------------------------------------PETK-------- 391

  Fly   461 NCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEGVDW 525
               ::..|||.||...||.|.|:|.|.| |..:|    ...::.|||                  
Human   392 ---RWKAGPWAPCSASCGGGSQSRSVYC-ISSDG----AGIQEAVEE------------------ 430

  Fly   526 IISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCSA 590
                               |.|....||           |...:.|...:| |.|....|.:||.
Human   431 -------------------AECAGLPGK-----------PPAIQACNLQRC-AAWSPEPWGECSV 464

  Fly   591 PCGKGVKSRIVIC-GEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCP----GEWFTGPWGK 650
            .||.||:.|.|.| ||......|.|     |:.|.:|...:.|..|:  ||    ..|..|.||.
Human   465 SCGVGVRKRSVTCRGERGSLLHTAA-----CSLEDRPPLTEPCVHED--CPLLSDQAWHVGTWGL 522

  Fly   651 CSKPCGGGERVREVLCLSNGTKSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEEDC 715
            |||.|..|.|.|:|:|             .:.|.|. |.|           ....||:  |.|.|
Human   523 CSKSCSSGTRRRQVIC-------------AIGPPSH-CGS-----------LQHSKPV--DVEPC 560

  Fly   716 DEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDS 780
            :.....|                          |:....|| |..||                  
Human   561 NTQPCHL--------------------------PQEVPSMQ-DVHTP------------------ 580

  Fly   781 ESTTDSGISTEGSGDDEETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSDSS 845
                                                       :|:........|:|        
Human   581 -------------------------------------------ASNPWMPLGPQESP-------- 594

  Fly   846 DSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTNASDSTPESSTEASSSTDDSTD 910
                                               ||||.|...|:...|               
Human   595 -----------------------------------ASDSRGQWWAAQEHP--------------- 609

  Fly   911 SSDNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTTENSSDSTSDATSDSTASSDSTDSTSDQ 975
                                     |:.|...|                       :..|...||
Human   610 -------------------------SARGDHRG-----------------------ERGDPRGDQ 626

  Fly   976 TTETTPESSTDSTESSTLDASSTTDASSTSESSSESSTDGSSTTSNSASSETTGLSSDGSTTDAT 1040
                       .|..|.|                                               
Human   627 -----------GTHLSAL----------------------------------------------- 633

  Fly  1041 TAASDNTDITTDGSTDESTDGSSNASTEGSTEGASEDTTISTESSGSTESTDAIASDGSTTEGST 1105
                                                                             
Human   634 ----------------------------------------------------------------- 633

  Fly  1106 VEDLSSSTSSDVTSDSTITDSSPSTEVSGSTDSSSSTDGSSTDASSTEASSTDVTESTDSTVSGG 1170
                                                                            |
Human   634 ----------------------------------------------------------------G 634

  Fly  1171 TSDTTESGPTEESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPYSFDSEVT 1235
            .:.:.:..|.::....||      |..|                                     
Human   635 PAPSLQQPPYQQPLRSGS------GPHD------------------------------------- 656

  Fly  1236 KSKPRKCKPKKSTCAKSEYGCCPDGKSTPKGPFDEGCPIAKTCADTKYGCCLDGVSPAKGKNNKG 1300
                         |..|.:||||||.:...||..:|||.| .|..::||||.|.||.|:|.::.|
Human   657 -------------CRHSPHGCCPDGHTASLGPQWQGCPGA-PCQQSRYGCCPDRVSVAEGPHHAG 707

  Fly  1301 CPKSQCAETLFGCCPDKFTAADGENDEGCPETTTVPPTTTTEETQPETTTEIEGSGQDSTTSEPD 1365
            |.||      :|          |::..|.|.:..|..|.                   ..|.:|.
Human   708 CTKS------YG----------GDSTGGMPRSRAVASTV-------------------HNTHQPQ 737

  Fly  1366 TKKSCSFSEFGCCPDAETSAKGPDFEGCGLASPVAKGCAESENGCCPDGQTPASGPNGEGCSGCT 1430
            .::                                                              
Human   738 AQQ-------------------------------------------------------------- 740

  Fly  1431 RERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARGPNNEGCECHYTPYGCCPDNKSAATG 1495
                             |:...|..:|||||.||:..|.||..|||                   
Human   741 -----------------NEPSECRGSQFGCCYDNVATAAGPLGEGC------------------- 769

  Fly  1496 YNQEGCACETTQYGCCPDKITAAKGPKHEGCPCETTQFGCCPDGLTFAKGPHHHGCHCTQTEFKC 1560
                                  ...|.|                                     
Human   770 ----------------------VGQPSH------------------------------------- 775

  Fly  1561 CDDEKTPAKGPNGDGCTCVESKFGCCPDGVTKATDEKFGGCENVQEPPQKACGLPKETGTCNNYS 1625
                ..|.:                                          |.||...|:|.:::
Human   776 ----AYPVR------------------------------------------CLLPSAHGSCADWA 794

  Fly  1626 VKYYFDTSYGGCARFWYGGCDGNDNRFESEAECKDTCQDYTGKHVCLLPKSAGPCTGFTKKWYFD 1690
            .::||..|.|.|.|||||||.||.|.|.||.||..:||                           
Human   795 ARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQ--------------------------- 832

  Fly  1691 VDRNRCEEFQYGGCYGTNNRFDSLEQCQGTCAASENLPTCEQPVESGPCAGNFERWYYDNETDIC 1755
                       |..:|                     |...||..||          ....||  
Human   833 -----------GSLHG---------------------PRRPQPGASG----------RSTHTD-- 853

  Fly  1756 RPFTYGGCKGNKNNYPTEHACNYNCRQPGVLKDRCALPKQTGDCSEKLAKWHFSESEKRCVPFYY 1820
                .||........|::|                    :||                       
Human   854 ----GGGSSPAGEQEPSQH--------------------RTG----------------------- 871

  Fly  1821 SGCGGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGN 1885
                                                                             
Human   872 ----------------------------------------------------------------- 871

  Fly  1886 ENRFPTEESCLARCDRKPEPTTTTPATRPQPSRQDVCDEEPAPGEC-STWVL-KWHFDRKIGACR 1948
                       |...|||.|:...       .||   |::|.|||. .|... :|.:.:::|:  
Human   872 -----------AAVQRKPWPSGGL-------WRQ---DQQPGPGEAPHTQAFGEWPWGQELGS-- 913

  Fly  1949 QFYYGNCGGNGNRFETENDCQQRCLSQEPPAPTPPRAPAPTRQPDPAPTVAQCSQPADPGQCDKW 2013
                                               |||                           
Human   914 -----------------------------------RAP--------------------------- 916

  Fly  2014 ALHWNYNETEGRCQSFYYGGCGGNDNRFATEEECSARCSVNIDIRIGADPVEHDTSKCFLA-FEP 2077
                               |.||                   |....|.|....:.:..|| .||
Human   917 -------------------GLGG-------------------DAGSPAPPFHSSSYRISLAGVEP 943

  Fly  2078 GNCYNNVTRWFYNSAEGLCDEFVYTGCGGNANNYATEEECQNECNDAQTTCALPPVRGRCSDLSR 2142
                        :..:....:.|...|..:     |..|.|                       .
Human   944 ------------SLVQAALGQLVRLSCSDD-----TAPESQ-----------------------A 968

  Fly  2143 RWYFDER--SGECHEFEFTGCRGNRNNFVSQSDCLNFCIGEPVVEPSAPTYSVCAEPPEAGECDN 2205
            .|..|.:  |.:.|..:|.|.                .|..|:....|.|||             
Human   969 AWQKDGQPISSDRHRLQFDGS----------------LIIHPLQAEDAGTYS------------- 1004

  Fly  2206 RTTAWFYDSENMACTAFTYTGCGGNGNRFETRDQCERQCGEFKGVDVCNEPVTTGPCTDWQTKYY 2270
                                                  ||            :|.|..|      
Human  1005 --------------------------------------CG------------STRPGRD------ 1013

  Fly  2271 FNTASQACEPFTYGGCDGTGNRFSDLFECQTVCLAGREPRVGSAKEICLLPVATGRCNGPSVHER 2335
                ||..:....||                      :..|.|..|:                  
Human  1014 ----SQKIQLRIIGG----------------------DMAVLSEAEL------------------ 1034

  Fly  2336 RWYYDDEAGNCVSFIYAGCSGNQNNFRSFEACTNQCRPEPNKQDNEIGQNPCDTFDAECQELRCP 2400
                                   :.|           |:|.....:.||                
Human  1035 -----------------------SRF-----------PQPRDPAQDFGQ---------------- 1049

  Fly  2401 YGVRRVAARSQPECTQCICENPCEGYSCPEGQQCAIDVASSDDRQFAPVCRDIYKPGECPALSAN 2465
                                                                           |.
Human  1050 ---------------------------------------------------------------AG 1051

  Fly  2466 ASGCARECYTDADCRGDNKCCSDGCGQLCVHPARPTQPPRTQAPVVSYPGDARAALEPKEAHELD 2530
            |:|                                        |:.:.|                
Human  1052 AAG----------------------------------------PLGAIP---------------- 1060

  Fly  2531 VQTAIGGIAVLRCFATGNPAPNITWSLKNLVINTNKGRYVLTANGDLTIVQVRQTDDGTYVCVAS 2595
                           :.:|.|     ...|.::.|:.|.|..:.|.    ::|.|          
Human  1061 ---------------SSHPQP-----ANRLRLDQNQPRVVDASPGQ----RIRMT---------- 1091

  Fly  2596 NGLGEPVRREVALQVTEPVSQPAYIYGDKNVTQIVELNRPAVIRCPAGGFPEPHVSWWRNGQMFG 2660
                                                        |.|.|||.|.:.|.|:||...
Human  1092 --------------------------------------------CRAEGFPPPAIEWQRDGQPVS 1112

  Fly  2661 LKNNLMARDYSLVFNSIQLSDLGLYTCEVYN----QRRPVSLRV----TLKAVGPVRPLSPEEEQ 2717
            ...:.:..|.|||.:.:.:.|.|.|||..:|    .:|.|.|||    |:..:.|.         
Human  1113 SPRHQLQPDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPT--------- 1168

  Fly  2718 YMQYVLNPATRPVTQRPSYPYRPTRPAYVPEPTVNVHAVLALEPKNSYTPGSTIVMSCSVQGYPE 2782
                        ||              |||                   |.|..:.|.|.| ..
Human  1169 ------------VT--------------VPE-------------------GDTARLLCVVAG-ES 1187

  Fly  2783 PNVTWIKDDVPLY-NNERVQITYQPHR-----LVLSDVTSADSGKYTCRASNAYTYANGEANVSI 2841
            .|:.|.::.:|:. :..||      |:     |::.::.:.|.|.|||.|.......:....|.:
Human  1188 VNIRWSRNGLPVQADGHRV------HQSPDGTLLIYNLRARDEGSYTCSAYQGSQAVSRSTEVKV 1246

  Fly  2842 QSVVPVSP------ECVDNPYFANCKLIVKGRYCSNPYYTQFCCRSCTLAGQVASP 2891
            .|..|.:.      :|||.|..|||.||::.:.|.|.||:.|||.||:.....|.|
Human  1247 VSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSRFQPHAQP 1302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 16/50 (32%)
ADAMTS_CR_3 116..213 CDD:437068 58/96 (60%)
ADAMTS_spacer1 222..329 CDD:461796 46/106 (43%)
TSP1_ADAMTS 347..396 CDD:465950 18/50 (36%)
TSP1_ADAMTS 400..457 CDD:465950 3/56 (5%)
TSP1_ADAMTS 465..520 CDD:465950 17/54 (31%)
TSP1_ADAMTS 580..632 CDD:465950 18/52 (35%)
TSP1_ADAMTS 643..693 CDD:465950 17/49 (35%)
MSCRAMM_ClfA <1049..1262 CDD:468110 14/212 (7%)
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681 25/50 (50%)
Kunitz_BPTI 1670..1721 CDD:425421 2/50 (4%)
Kunitz-type 1730..1780 CDD:438633 10/49 (20%)
Kunitz_BPTI 1789..1840 CDD:425421 2/50 (4%)
Kunitz_papilin_mig6-like 1849..1899 CDD:438679 1/49 (2%)
Kunitz_papilin_mig6-like 1922..1972 CDD:438679 8/51 (16%)
Kunitz_papilin_mig6-like 2001..2051 CDD:438679 3/49 (6%)
Kunitz-type 2071..2121 CDD:438633 9/50 (18%)
Kunitz_BPTI 2127..2178 CDD:425421 6/52 (12%)
Kunitz_BPTI 2193..2245 CDD:425421 0/51 (0%)
Kunitz_BPTI 2252..2303 CDD:425421 7/50 (14%)
Kunitz_BPTI 2317..2372 CDD:425421 1/54 (2%)
WAP 2455..2497 CDD:459672 3/41 (7%)
Ig 2530..2610 CDD:472250 9/79 (11%)
Ig strand B 2539..2543 CDD:409353 0/3 (0%)
Ig strand C 2552..2556 CDD:409353 0/3 (0%)
Ig strand E 2576..2579 CDD:409353 0/2 (0%)
Ig strand F 2589..2594 CDD:409353 0/4 (0%)
Ig strand G 2603..2606 CDD:409353 0/2 (0%)
IG_like 2627..2703 CDD:214653 26/83 (31%)
Ig strand B 2636..2640 CDD:409353 0/3 (0%)
Ig strand C 2649..2653 CDD:409353 0/3 (0%)
Ig strand E 2670..2674 CDD:409353 2/3 (67%)
Ig strand F 2684..2689 CDD:409353 3/4 (75%)
Ig strand G 2697..2700 CDD:409353 1/2 (50%)
I-set 2766..2845 CDD:400151 20/84 (24%)
Ig strand B 2771..2775 CDD:409353 0/3 (0%)
Ig strand C 2784..2788 CDD:409353 1/3 (33%)
Ig strand F 2821..2826 CDD:409353 3/4 (75%)
PLAC 2851..2883 CDD:462560 17/31 (55%)
PAPLNXP_047287828.1 ADAMTS_CR_3 112..209 CDD:437068 58/96 (60%)
ADAMTS_spacer1 211..325 CDD:461796 47/113 (42%)
TSP1_ADAMTS 335..387 CDD:465950 20/55 (36%)
TSP1_ADAMTS 393..451 CDD:465950 23/110 (21%)
TSP1_ADAMTS 454..507 CDD:465950 20/59 (34%)
TSP1_ADAMTS 515..565 CDD:465950 22/76 (29%)
Kunitz_papilin 781..831 CDD:438678 25/49 (51%)
Papilin_u7 841..932 CDD:374683 36/337 (11%)
Ig 941..>1005 CDD:472250 19/170 (11%)
Ig strand B 954..958 CDD:409353 1/3 (33%)
Ig strand C 967..971 CDD:409353 1/26 (4%)
Ig strand E 988..992 CDD:409353 1/19 (5%)
I-set 1076..1146 CDD:400151 25/127 (20%)
Ig strand B 1088..1092 CDD:409353 2/57 (4%)
Ig strand C 1101..1105 CDD:409353 0/3 (0%)
Ig strand E 1122..1126 CDD:409353 2/3 (67%)
Ig strand F 1136..1141 CDD:409353 3/4 (75%)
IG_like 1166..1246 CDD:214653 25/140 (18%)
Ig strand B 1177..1181 CDD:409353 0/3 (0%)
Ig strand C 1189..1193 CDD:409353 1/3 (33%)
Ig strand E 1212..1216 CDD:409353 1/3 (33%)
Ig strand F 1226..1231 CDD:409353 3/4 (75%)
Ig strand G 1239..1242 CDD:409353 0/2 (0%)
PLAC 1262..1294 CDD:462560 17/31 (55%)

Return to query results.
Submit another query.