DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and HMCN1

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_114141.2 Gene:HMCN1 / 83872 HGNCID:19194 Length:5635 Species:Homo sapiens


Alignment Length:1622 Identity:321/1622 - (19%)
Similarity:481/1622 - (29%) Gaps:596/1622 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 LNCMPKGERFYYRQREKVVDGT---RCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDG 210
            |||..||            |.|   :.|.|.:|:.::.....:|    .||.|......:..|| 
Human  4369 LNCEVKG------------DPTPTIQWNRKGVDIEISHRIRQLG----NGSLAIYGTVNEDAGD- 4416

  Fly   211 STCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIE--ETVPSSNYLACRNHSGHYYLN----GDW 269
            .||      :.|.:.......:.|..:....|.:|  |||        .|..|...||    |: 
Human  4417 YTC------VATNEAGVVERSMSLTLQSPPIITLEPVETV--------INAGGKIILNCQATGE- 4466

  Fly   270 RIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQE---------KNISLDYE 325
                |:|..   :|   .|:....:..|::....  :.||:|....:|         :|:.....
Human  4467 ----PQPTI---TW---SRQGHSISWDDRVNVLS--NNSLYIADAQKEDTSEFECVARNLMGSVL 4519

  Fly   326 YSIPESL----SHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPV 386
            ..:|..:    ..||     |:  .:.|||.:||.|.|.|...||..:......|  |  :...:
Human  4520 VRVPVIVQVHGGFSQ-----WS--AWRACSVTCGKGIQKRSRLCNQPLPANGGKP--C--QGSDL 4573

  Fly   387 EEQACGTEPCAPHWVEGEWS------KCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEV 445
            |.:.|..:||.   |:|.||      :|::.||. |.|.|:.||.  :.|.:|            
Human  4574 EMRNCQNKPCP---VDGSWSEWSLWEECTRSCGR-GNQTRTRTCN--NPSVQH------------ 4620

  Fly   446 GNKPATKQE-----CNRDVKNCPKYHL----GPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPE 501
            |.:|.....     ||  ::.||.:..    .||..|.:.||.|.|||...|    |........
Human  4621 GGRPCEGNAVEIIMCN--IRPCPVHGAWSAWQPWGTCSESCGKGTQTRARLC----NNPPPAFGG 4679

  Fly   502 EDCVEEKPET------EKSCLLTPCEG--VDWIISQWSGCN-ACGQNTETRTAIC--------GN 549
            ..|  :..||      |::|   |..|  ..|  :.||.|: :||.....||..|        |.
Human  4680 SYC--DGAETQMQVCNERNC---PIHGKWATW--ASWSACSVSCGGGARQRTRGCSDPVPQYGGR 4737

  Fly   550 K-EGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTP 613
            | ||.....:||.      |.||.:....:.|  |.|..||..|..|...|...|     ....|
Human  4738 KCEGSDVQSDFCN------SDPCPTHGNWSPW--SGWGTCSRTCNGGQMRRYRTC-----DNPPP 4789

  Fly   614 ADDDSKCNKETKPESE-QDCEGEEKVCP-----GEWFTGPWGKCSKPCGGGERVREVLCLSNGTK 672
            ::....|.   .|:|: |.|..:  :||     |.|.:  |.:||..|||||:.|:.||      
Human  4790 SNGGRACG---GPDSQIQRCNTD--MCPVDGSWGSWHS--WSQCSASCGGGEKTRKRLC------ 4841

  Fly   673 SVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVI 737
                                            |.|:.                            
Human  4842 --------------------------------DHPVP---------------------------- 4846

  Fly   738 DLEGTAKTETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDSESTTDSGISTEGSGDDEETSEA 802
                             ::...|.|.|..:.|....:......:....|.|   |:.:|.|...|
Human  4847 -----------------VKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVI---GNINDVEFGIA 4891

  Fly   803 STDLSSSTDSGSTSSDSTSSDS---SSSISSDATSEAPA-------------SSVSDSSDSTDAS 851
            ..:        :|.:||.:||:   .:.|::...|...|             ::..:..::.:..
Human  4892 FLN--------ATITDSPNSDTRIIRAKITNVPRSLGSAMRKIVSILNPIYWTTAKEIGEAVNGF 4948

  Fly   852 TETTGVSDDSTDVSSSTEASASESTDVSGASDSTGS----TNASDSTPESSTEASSSTDDSTDSS 912
            |.|..|....|.|..:| ....:.:.::...||.||    ...|....:..:.|..:..|.|:  
Human  4949 TLTNAVFKRETQVEFAT-GEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAEVTVKDYTE-- 5010

  Fly   913 DNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTTENSSDSTSDATSDSTASSDSTDSTSDQTT 977
                               |...:..|.....|:........:...|.:.|...|..........
Human  5011 -------------------DYIQTGPGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLV 5056

  Fly   978 ETTPESSTDSTESSTLDASSTTDASSTSESSSESSTDGSSTTSNSASSETTGLSSDGSTTDAT-T 1041
            ||...||.:|            |.:...|      |.|....::.:..:.:.....|.|.|:. .
Human  5057 ETLHASSVES------------DYNQIEE------TLGFKIHASISKGDRSNQCPSGFTLDSVGP 5103

  Fly  1042 AASDNTDITTDGSTDESTDGSSNASTEGSTEGASEDTTISTESSGSTESTDAIASDGSTTEGSTV 1106
            ..:|.         ||...|:..:.:..:..|    |...:...|.|     ||:||.|.:....
Human  5104 FCADE---------DECAAGNPCSHSCHNAMG----TYYCSCPKGLT-----IAADGRTCQDIDE 5150

  Fly  1107 EDLSSST-SSDVTSDSTITDSSPSTEVSGSTDSSSSTDGSSTDASSTEASSTDVTESTDSTVSGG 1170
            ..|...| .:....|:||  .|....|...:....::||         .|..|:.|         
Human  5151 CALGRHTCHAGQDCDNTI--GSYRCVVRCGSGFRRTSDG---------LSCQDINE--------- 5195

  Fly  1171 TSDTTESGPTEES--TTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPYSFDSE 1233
               ..||.|..:.  ...||.....|..........:|                           
Human  5196 ---CQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMD--------------------------- 5230

  Fly  1234 VTKSKPRKCKPK---KSTCAKSEYGC---CPDGKSTPKGPFDEGCPIAKTCADTKYGCCLDGVSP 1292
            |.:.:...|:|.   |:|  :..|.|   ||:|.:..:.         .||.|...  |.||...
Human  5231 VNECRQNVCRPDQHCKNT--RGGYKCIDLCPNGMTKAEN---------GTCIDIDE--CKDGTHQ 5282

  Fly  1293 AKGKNNKGCPKSQCAETLFG---C-CPDKFTAADGENDEGCPETTTVPPTTTTEETQPETTTEIE 1353
                    |..:|..|...|   | ||..:.:                                :
Human  5283 --------CRYNQICENTRGSYRCVCPRGYRS--------------------------------Q 5307

  Fly  1354 GSGQDSTTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGCGLASPVAKGCAESENG--C-CPDGQ 1415
            |.|:.                   |.|.....:.|        .|.|..|:.:...  | ||.||
Human  5308 GVGRP-------------------CMDINECEQVP--------KPCAHQCSNTPGSFKCICPPGQ 5345

  Fly  1416 TPASGPNGEGCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARGP--NNEGCEC 1478
            ....  :|:.|:|..|          .|.:|         ||:.   ...||...|  ||...:.
Human  5346 HLLG--DGKSCAGLER----------LPNYG---------TQYS---SYNLARFSPVRNNYQPQQ 5386

  Fly  1479 HYTPYG-------------------------CCPDNKSAATGYNQEGCA----CETTQYGCCPDK 1514
            ||..|.                         .||:...|    :.:.|.    ||.|.  .|   
Human  5387 HYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEA----SHDTCVDIDECENTD--AC--- 5442

  Fly  1515 ITAAKGPKHEGCPCETTQFG---C-CPDGLTFAKGPHHHGCHCTQTEFKCCDD-----EKTPAKG 1570
                   :||   |:.| ||   | ||.|....    |:|        |.|.|     |:....|
Human  5443 -------QHE---CKNT-FGSYQCICPPGYQLT----HNG--------KTCQDIDECLEQNVHCG 5484

  Fly  1571 PNGDGCTCVESKFGC----CPDGVTKATDEKFGGCENVQEPPQKACGLPKETGTCNNYSVKY 1628
            || ..|..:...:.|    ||....:  |...|.|.....|....|.|       :.|:::|
Human  5485 PN-RMCFNMRGSYQCIDTPCPPNYQR--DPVSGFCLKNCPPNDLECAL-------SPYALEY 5536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607 22/129 (17%)
TSP1 468..521 CDD:214559 17/58 (29%)
TSP_1 645..693 CDD:278517 11/47 (23%)
Kunitz_BPTI 1611..1663 CDD:278443 4/18 (22%)
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
HMCN1NP_114141.2 VWA_2 42..212 CDD:290253
IG_like 440..512 CDD:214653
Ig 451..510 CDD:299845
IG 526..608 CDD:214652
IGc2 533..593 CDD:197706
I-set 612..696 CDD:254352
Ig 626..696 CDD:299845
IG 708..789 CDD:214652
Ig 720..786 CDD:143165
Ig 792..884 CDD:299845
I-set 793..884 CDD:254352
I-set 890..977 CDD:254352
IGc2 903..967 CDD:197706
Ig 980..1071 CDD:299845
IG 1086..1167 CDD:214652
Ig 1086..1167 CDD:299845
I-set 1171..1258 CDD:254352
Ig 1188..1256 CDD:299845
Ig 1261..1357 CDD:299845
IG_like 1276..1355 CDD:214653
IG_like 1369..1448 CDD:214653
IGc2 1382..1438 CDD:197706
I-set 1452..1542 CDD:254352
Ig 1460..1542 CDD:299845
IG 1556..1635 CDD:214652
Ig 1557..1635 CDD:299845
I-set 1647..1729 CDD:254352
Ig 1648..1725 CDD:299845
IGc2 1752..1812 CDD:197706
IG_like 1843..1915 CDD:214653
IGc2 1843..1905 CDD:197706
IG 1929..2008 CDD:214652
Ig 1934..2008 CDD:299845
Ig 2031..2092 CDD:299845
I-set 2111..2191 CDD:254352
IGc2 2119..2181 CDD:197706
I-set 2203..2286 CDD:254352
Ig <2222..2277 CDD:299845
IG_like 2299..2380 CDD:214653
Ig 2299..2370 CDD:299845
I-set 2391..2474 CDD:254352
IGc2 2400..2464 CDD:197706
I-set 2478..2567 CDD:254352
IGc2 2493..2557 CDD:197706
I-set 2582..2663 CDD:254352
IGc2 2594..2653 CDD:197706
I-set 2681..2762 CDD:254352
IGc2 2689..2752 CDD:197706
IG_like 2789..2865 CDD:214653
IGc2 2791..2855 CDD:197706
I-set 2879..2960 CDD:254352
Ig 2879..2950 CDD:299845
Ig 2963..3054 CDD:299845
I-set 2970..3052 CDD:254352
I-set 3066..3147 CDD:254352
IGc2 3073..3137 CDD:197706
I-set 3151..3241 CDD:254352
IGc2 3167..3228 CDD:197706
Ig 3244..3338 CDD:299845
I-set 3252..3336 CDD:254352
I-set 3356..3430 CDD:254352
IGc2 3357..3420 CDD:197706
Ig 3433..3523 CDD:299845
IG_like 3443..3523 CDD:214653
IG_like 3536..3616 CDD:214653
IGc2 3543..3606 CDD:197706
I-set 3628..3709 CDD:254352
IGc2 3636..3699 CDD:197706
I-set 3719..3800 CDD:254352
Ig 3719..3795 CDD:299845
I-set 3804..3893 CDD:254352
Ig 3810..3883 CDD:299845
Ig 3896..3984 CDD:299845
IG_like 3903..3984 CDD:214653
Ig 3987..4067 CDD:299845
IG 3994..4075 CDD:214652
I-set 4079..4165 CDD:254352
IGc2 4093..4155 CDD:197706
Ig 4168..4258 CDD:299845
IG_like 4176..4256 CDD:214653
I-set 4260..4345 CDD:254352
IGc2 4274..4335 CDD:197706
IG 4356..4435 CDD:214652 19/88 (22%)
Ig 4356..4435 CDD:299845 19/88 (22%)
I-set 4440..4526 CDD:254352 21/106 (20%)
Ig 4443..4521 CDD:299845 19/98 (19%)
TSP1 4533..4584 CDD:214559 18/61 (30%)
TSP1 4589..4641 CDD:214559 16/68 (24%)
TSP1 4646..4698 CDD:214559 16/60 (27%)
TSP1 4703..4755 CDD:214559 17/59 (29%)
TSP1 4760..4812 CDD:214559 15/63 (24%)
TSP1 4817..4869 CDD:214559 19/136 (14%)
G2F 4868..5092 CDD:214774 43/274 (16%)
EGF_CA 5107..5146 CDD:214542 13/56 (23%)
EGF_CA 5147..5190 CDD:284955 9/53 (17%)
EGF_CA 5192..5228 CDD:214542 8/47 (17%)
EGF_CA 5230..5263 CDD:238011 11/61 (18%)
EGF_CA 5272..5313 CDD:284955 13/101 (13%)
EGF_CA 5315..5354 CDD:214542 11/48 (23%)
EGF_CA 5432..5471 CDD:214542 17/66 (26%)
EGF_CA 5472..5508 CDD:214542 9/36 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10653
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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