DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and THSD4

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001381461.1	Gene:	THSD4 / 79875	HGNCID:	25835	Length:	1018	Species:	Homo sapiens

Alignment Length:	719	Identity:	233/719 - (32%)
Similarity:	324/719 - (45%)	Gaps:	112/719 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 RGEAV-CSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVPYTNAP--NPCELNC 151
            |..|: |.|..|:|..|||..|||.....|..||:.::.:.|.|.||||.|:....  ..|||||
Human   285 RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNC 349

  Fly   152 MPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTI 216
            ...|.|||.||.|||:|||.|:.....:||:|:|..:|||..||||...|||..||||.:.|:.:
Human   350 QAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVV 414

  Fly   217 RNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFAN 281
            .........:.||:.::.:|||||.|.|.|...|:||||.|:.||...:||:|.||.|.......
Human   415 SGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGG 479

  Fly   282 SWWNYQR-KPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSI----------------- 328
            :.:.|:| ..:...|.:.....||.:|.|.:.|:.|:.|..:.|||.|
Human   480 TMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPG 544

  Fly   329 -------------------------------------------------PESLSHSQQDT----- 339
                                                             |:..|..:.|.
Human   545 EPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPA 609

  Fly   340 ---------HTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPV-EEQACGTE 394
                     |.|.......||.:||.|||.....|.:|.|..|...|.||...||. ||:.|...
Human   610 PQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIF 674

  Fly   395 PCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDV 459
            ||...|..||||:|||.||. |.|:|.:.|.::.::...||:.......|   ||.|...|  .:
Human   675 PCPAFWDIGEWSECSKTCGL-GMQHRQVLCRQVYANRSLTVQPYRCQHLE---KPETTSTC--QL 733

  Fly   460 KNCPKYHL-GPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDC-VEEKPETEKSCLLTPCEG 522
            |.|.::.: ..||.|...||.|::||.|.| :...|.  |:.:|:| ::.:|...::|.:.|| .
Human   734 KICSEWQIRTDWTSCSVPCGVGQRTRDVKC-VSNIGD--VVDDEECNMKLRPNDIENCDMGPC-A 794

  Fly   523 VDWIISQWS-GCNA-CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKC--EAQWFSS 583
            ..|.:::|| .|:| ||....||:.:|........|.|.|....|..:.||.:..|  :.:||:.
Human   795 KSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAG 859

  Fly   584 EWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPW 648
            .||:||..||.|.:.|.|||...:..|.... |.|:|:...||.|:|.|  ..|.|..:||:..|
Human   860 SWSQCSIECGSGTQQREVICVRKNADTFEVL-DPSECSFLEKPPSQQSC--HLKPCGAKWFSTEW 921

  Fly   649 GKCSKPCGGGERVREVLCLSNG-TKSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDE 712
            ..|||.|.||.|||||.|||:. |.|..||.:......|.||.:.|..:       .|:..:|..
Human   922 SMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPE-------VDENCKDKY 979

  Fly   713 EDCD 716
            .:|:
Human   980 YNCN 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	9/21 (43%)
		ADAM_spacer1	214..329	CDD:283607	38/181 (21%)
		TSP1	468..521	CDD:214559	17/53 (32%)
		TSP_1	645..693	CDD:278517	22/48 (46%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
THSD4	NP_001381461.1	TSP1	58..>95	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..235
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..279
		ADAM_spacer1	412..528	CDD:368694	37/115 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..623		5/88 (6%)
		TSP1_ADAMTS	627..676	CDD:408800	19/48 (40%)
		TSP1_ADAMTS	680..736	CDD:408800	22/61 (36%)
		TSP1_ADAMTS	739..793	CDD:408800	16/56 (29%)
		TSP1_ADAMTS	797..850	CDD:408800	16/52 (31%)
		TSP1_ADAMTS	856..912	CDD:408800	23/58 (40%)
		TSP1_ADAMTS	916..967	CDD:408800	24/50 (48%)
		PLAC	975..1005	CDD:400844	2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11779
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810