Protein Alignment Ppn and TFPI2

DIOPT Version :10

• Sequence 1: NP_788752.2
• Gene: Ppn / 43872
• FlyBaseID: FBgn0003137
• Length: 2898
• Species: Drosophila melanogaster
• Sequence 2: NP_006519.1
• Gene: TFPI2 / 7980
• HGNCID: 11761
• Length: 235
• Species: Homo sapiens
• Alignment Length: 201
• Identity: 69/201 - (34%)
• Similarity: 100/201 - (49%)
• Gaps: 7/201 - (3%)

  Fly  1652 FESEAECKDTCQDYTGKH--VCLLPKSAGPCTGFTKKWYFDVDRNRCEEFQYGGCYGTNNRFDSL 1714
            |.:||...|..|:.||.:  :||||...|||.....::|:|.....|.:|.||||.|..|.|.:.
Human    15 FLTEAALGDAAQEPTGNNAEICLLPLDYGPCRALLLRYYYDRYTQSCRQFLYGGCEGNANNFYTW 79

  Fly  1715 EQCQGTCAASENLP-TCEQPVE-SGPCAGNFERWYYDNETDICRPFTYGGCKGNK--NNYPTEHA 1775
            |.|...|...|.:| .|...|. ...|.|:.|:::::..:..|..|..|||..|:  |.:|.|..
Human    80 EACDDACWRIEKVPKVCRLQVSVDDQCEGSTEKYFFNLSSMTCEKFFSGGCHRNRIENRFPDEAT 144

  Fly  1776 CNYNCRQPGVLKDRCALPKQTGDCSEKLAKWHFSESEKRCVPFYYSGCGGNKNNFPTLESCEDHC 1840
            |...| .|..:...|..||..|.||..:.:::|:...:.|..|.|:|||||.|||.:.|.|:..|
Human   145 CMGFC-APKKIPSFCYSPKDEGLCSANVTRYYFNPRYRTCDAFTYTGCGGNDNNFVSREDCKRAC 208

  Fly  1841 PRQVAK 1846
            .:.:.|
Human   209 AKALKK 214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAMTS_CR_3	116..213	CDD:437068
		ADAMTS_spacer1	222..329	CDD:461796
		TSP1_ADAMTS	347..396	CDD:465950
		TSP1_ADAMTS	400..457	CDD:465950
		TSP1_ADAMTS	465..520	CDD:465950
		TSP1_ADAMTS	580..632	CDD:465950
		TSP1_ADAMTS	643..693	CDD:465950
		MSCRAMM_ClfA	<1049..1262	CDD:468110
		Kunitz_papilin_lacunin-like	1612..1663	CDD:438681	4/10 (40%)
		Kunitz_BPTI	1670..1721	CDD:425421	20/50 (40%)
		Kunitz-type	1730..1780	CDD:438633	15/52 (29%)
		Kunitz_BPTI	1789..1840	CDD:425421	20/50 (40%)
		Kunitz_papilin_mig6-like	1849..1899	CDD:438679
		Kunitz_papilin_mig6-like	1922..1972	CDD:438679
		Kunitz_papilin_mig6-like	2001..2051	CDD:438679
		Kunitz-type	2071..2121	CDD:438633
		Kunitz_BPTI	2127..2178	CDD:425421
		Kunitz_BPTI	2193..2245	CDD:425421
		Kunitz_BPTI	2252..2303	CDD:425421
		Kunitz_BPTI	2317..2372	CDD:425421
		WAP	2455..2497	CDD:459672
		Ig	2530..2610	CDD:472250
		Ig strand B	2539..2543	CDD:409353
		Ig strand C	2552..2556	CDD:409353
		Ig strand E	2576..2579	CDD:409353
		Ig strand F	2589..2594	CDD:409353
		Ig strand G	2603..2606	CDD:409353
		IG_like	2627..2703	CDD:214653
		Ig strand B	2636..2640	CDD:409353
		Ig strand C	2649..2653	CDD:409353
		Ig strand E	2670..2674	CDD:409353
		Ig strand F	2684..2689	CDD:409353
		Ig strand G	2697..2700	CDD:409353
		I-set	2766..2845	CDD:400151
		Ig strand B	2771..2775	CDD:409353
		Ig strand C	2784..2788	CDD:409353
		Ig strand F	2821..2826	CDD:409353
		PLAC	2851..2883	CDD:462560
TFPI2	NP_006519.1	Kunitz_TFPI2_1-like	32..88	CDD:438659	21/55 (38%)
		Kunitz_BPTI	95..149	CDD:425421	15/53 (28%)
		Kunitz_TFPI1_TFPI2_3-like	155..204	CDD:438658	19/48 (40%)