DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppn and Adamtsl2

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_084257.1 Gene:Adamtsl2 / 77794 MGIID:1925044 Length:957 Species:Mus musculus


Alignment Length:937 Identity:239/937 - (25%)
Similarity:352/937 - (37%) Gaps:304/937 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 PESSVTPGGEGNDP---DEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDR-----GEAVCSGGSR 100
            |.|:...||.....   .|||.|::   |||:|||||:.|.|.||::..:     |...|.|.|:
Mouse    34 PTSNSLEGGADTTAYWWGEWTKWTA---CSRSCGGGVTSQERHCLQQRRKSVPGTGNRTCVGTSK 95

  Fly   101 RYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVP-----YTN-APNPCELNCMPKGERFY 159
            ||..|..|:||.:...||.:||..|:.:.:||..|:|.|     |.: :..||:|:|....    
Mouse    96 RYQLCRVQECPPDGRSFREEQCVSFNSRVYDGRAYQWKPLYPDDYVHISSKPCDLHCSTVD---- 156

  Fly   160 YRQREKVV---DGTRCNDKDL-DVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTI 220
             .||:..|   |||.|...|| .|||:|:|.|:|||.:|.|....|||..|.||||:|..:....
Mouse   157 -GQRQLTVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGVCQGDGSSCTHVTGNY 220

  Fly   221 TTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWN 285
            ...:...||:.:..:|.||.:|:|.|...|::.||..:.:|.|:.||::::|.|:....|.:...
Mouse   221 RKGNNHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGFYFFNGNYKVDSPKNFNIAGTVVK 285

  Fly   286 YQRKPMGF--AAPDQLTCSGPISESLFIVMLVQE-KNISLDYE----------------YSIPES 331
            | |:||..  ...:.:...||.::.|.:::..|. |:.|:.:|                ||..|:
Mouse   286 Y-RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQSPHMHHLPPVYYSFSEA 349

  Fly   332 LSHSQQDT--------------------------------------------------------- 339
            .|.|.:.|                                                         
Mouse   350 ASQSTESTERQELDSARLLGFMQHNGSLYRQTSSERLGLNSQLFQPPAPEVELGPSRGQESNEVC 414

  Fly   340 -------------------HTWTHHQFNA------------------------------------ 349
                               |..|...|:|                                    
Mouse   415 KQASGGVCEGPPRGKGFQDHNATGRAFSADKDDREISAHFTSHELLSANTISDQLLGTGSESEEF 479

  Fly   350 ----------------------------------------------------------------- 349
                                                                             
Mouse   480 SLNETMNSIFAQGAPRSSPAESLYVDYEENEGPAAYLINGSYLELSSDRINTSSEAPFPNTSASP 544

  Fly   350 -------------------------------------CSASCGGGSQSRKVTCNNRITLAEVNPS 377
                                                 |||:|..|..|....| .|....||:.|
Mouse   545 PNLAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSTYAMC-VRYDGVEVDDS 608

  Fly   378 LCD--QKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSG-EHTVEEDA 439
            .||  .:.:||.|...|.| |.|.|....||:||:.|| :|.|.|.:.|.::.|.| :.:|..| 
Mouse   609 YCDALTRPEPVHEFCAGRE-CQPRWETSSWSECSRTCG-EGHQFRIVRCWKMLSPGFDSSVYSD- 670

  Fly   440 VCLKEVGNKPATKQECNRDVKNC-PKYHLGPWTPCDKLCGD-GKQTRKVTCFIEENGHKRVLPEE 502
            :|......:|..::.|....  | |::.:..|:.|...||: ...||.:.|..:|   |...|  
Mouse   671 LCEATEAVRPEERKTCRNPA--CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDE---KLCDP-- 728

  Fly   503 DCVEEKPETEKSCLLTPCEGVDWIISQWSGCN-ACGQNTETRTAICGNKEGKVYPEEFCEPEV-P 565
               ..||..||:|...||:. .|.:|.|..|: :|||....|...|...:|:|.||..|:.|. |
Mouse   729 ---STKPVGEKNCTGPPCDR-QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQTETKP 789

  Fly   566 TLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEF-DGKTVTPADDDSKCNKETKPESE 629
            ....||....|.|.|.:.:|.:|:..||:|||.|:|:|.|. :||....:..:  |....||..|
Mouse   790 LAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQIRSGPE--CGLARKPPEE 852

  Fly   630 QDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSV-NCDEEKVEPLSEKCNSEAC 693
            ..|  .|:.| .:|:|.||.:|:|.||.|.|:|:|.|. .||..| .||     ||.:....:||
Mouse   853 STC--FERPC-FKWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCD-----PLVKPVGRQAC 908

  Fly   694 TEDEILPLTSTDKPIEDDEEDC-DEDG 719
               ::.|.     |.|..::.| |:.|
Mouse   909 ---DLQPC-----PTEPPDDSCQDQPG 927

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 23/55 (42%)
ADAM_spacer1 214..329 CDD:283607 31/133 (23%)
TSP1 468..521 CDD:214559 16/53 (30%)
TSP_1 645..693 CDD:278517 19/48 (40%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Adamtsl2NP_084257.1 TSP1 50..106 CDD:214559 24/58 (41%)
ADAM_spacer1 216..330 CDD:368694 29/114 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..568 0/35 (0%)
TSP1_ADAMTS 632..691 CDD:408800 18/62 (29%)
TSP1_ADAMTS 695..743 CDD:408800 15/55 (27%)
TSP1_ADAMTS 747..800 CDD:408800 18/52 (35%)
TSP1_ADAMTS 804..860 CDD:408800 20/59 (34%)
TSP1_ADAMTS 863..913 CDD:408800 22/58 (38%)
PLAC 922..953 CDD:400844 3/6 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.