DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppn and Adamtsl1

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_006538438.1 Gene:Adamtsl1 / 77739 MGIID:1924989 Length:1999 Species:Mus musculus


Alignment Length:1872 Identity:393/1872 - (20%)
Similarity:608/1872 - (32%) Gaps:512/1872 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 DEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQC 122
            |.|.||   |:||||||||.||..|.||     ....|.|.:.||.:|:..|||.|..|||||||
Mouse   266 DAWGPW---SECSRTCGGGASYSLRRCL-----SSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQC 322

  Fly   123 SRFDRQQFDGVFYEWVPYTNAP-NPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECM 186
            |..:..::.|..|||:|.:|.| |||.|.|..||.........||:|||||..:.||:|::|.|.
Mouse   323 SAHNDVKYHGQLYEWLPVSNDPDNPCSLKCQAKGTSLVVELAPKVLDGTRCYTESLDMCISGLCQ 387

  Fly   187 PVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYND-LLLLPEGATNIRIEETVPS 250
            .||||..|||..|||.|..|.||||||:.:|....::..|...:| ::.:|.|:.:||:....|.
Mouse   388 IVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSASKSDDTVVAIPYGSRHIRLVLKGPD 452

  Fly   251 SNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQ--LTCSGPISESLFIVM 313
            ..||..:...|   ..|:..:.........||..::|:      .||:  |..:||::....|  
Mouse   453 HLYLETKTLQG---TKGENSLSSTGIFLVDNSTVDFQK------LPDKEILRMTGPLTADFII-- 506

  Fly   314 LVQEKNISLDYEYSIPESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTC----NNRITLAEV 374
                |...|....|..:.:.: |...|.|....|..|||:||||.|.....|    :||:    |
Mouse   507 ----KIHDLGPADSTVQFIFY-QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV----V 562

  Fly   375 NPSLC-----DQKSKPVEEQACGTEPC-----------------APHWVEGEWSKCSKGCGSDGF 417
            ....|     :.|.|| :.|.|..:||                 .|.|....|:.||..||. |.
Mouse   563 ADQYCHYYPENVKPKP-KLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG-GI 625

  Fly   418 QNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQ 482
            |:|:::|......|..|..|:..|:  ...|....|.||  :.:|||:....|:||...||.|.:
Mouse   626 QSRAVSCVEEDIQGHVTSVEEWKCM--YTPKMPVVQPCN--IFDCPKWLAQEWSPCTVTCGQGLR 686

  Fly   483 TRKVTCFIEENGHK--------------------------------------------------- 496
            .|.|.|......|.                                                   
Mouse   687 YRVVLCIDHRGMHTGGCSAKTKPHIKEECIIPTPCYKPREKLPIEAKLPWFKQAQELEEGAAVSE 751

  Fly   497 ----------------------RV---------------LPEEDCVEEKPETEKSCLLTPCEG-- 522
                                  |:               ||.::|...||.::::|...||.|  
Mouse   752 EPSFIPEAWSACTVTCGVGTQVRIIRCQVLLPFSQSVADLPADECEGPKPASQRACYAGPCNGET 816

  Fly   523 ----------------------------------------------------------------- 522
                                                                             
Mouse   817 PEFNPDNGDGLLGGLQDLDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRELADENLCVTSR 881

  Fly   523 ---------------VDWIISQWSGCN-ACGQNTETRTAICGN------KEGKVYPEEFCEPEVP 565
                           ..|.|.:||.|: .||...:||..:|.:      .|..|..:|.|....|
Mouse   882 RPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVVCSHLLSREMNEVVVLADELCHHPKP 946

  Fly   566 TLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGE--FDGKTV-TPADDDSKCNKETKPE 627
            :..:.|....|...|:.::|..||..||.|::.|.|:|.:  .||..: .|   ::.|: .:||.
Mouse   947 STVQACNRFNCPPAWYPAQWQLCSRTCGGGIQKRDVLCKQRMADGSFLELP---ETFCS-ASKPT 1007

  Fly   628 SEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLC---LSNGTKSVNCDEEKVEPLSEKCN 689
            |.|.|:.::  ||.||....|.:||..||.|.:.|..:|   |..|..:|             .|
Mouse  1008 SHQGCKKDD--CPSEWLLSEWSECSVSCGEGTQTRSAICQRVLKTGVSTV-------------VN 1057

  Fly   690 SEACTEDEILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVIDLEGTAKTET------- 747
            |..|..   ||.:|:.:|..  ...|...|        ....|....|........:|       
Mouse  1058 STLCPP---LPFSSSIRPCM--LATCARPG--------RPSTKHSPHIAAARNIYIQTRRQRKLH 1109

  Fly   748 ---------TPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDSEST------------------TD 785
                     .|:...:::    .|...|.....|:|..|..|.|:                  :|
Mouse  1110 FVVGGFAYLLPKTTVVLR----CPTRRFRKPLITWEKDGQHSISSAHVTVAPFGYLKIHRLKPSD 1170

  Fly   786 SGISTEGSGDDEETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSDSSD---S 847
            :||.|..:|...|  :....|............|..|:...::....|:...|.......:   |
Mouse  1171 AGIYTCSAGPARE--QFVIKLIGGNRKLVARPLSLWSEEEEALQVRKTNPKEALQTHKHQNGIFS 1233

  Fly   848 TDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTNASDSTPESSTEASSSTDDSTDSS 912
            ..:..|..|:   :.|..:..:...|...:..|   ..|...||....:|:...:||.:|     
Mouse  1234 NGSKAEKRGL---TADPGNRYDDIVSRLLEQGG---WPGELLASWEVQDSAERNASSEED----- 1287

  Fly   913 DNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTTENSSDSTSDATSDSTASSDSTD--STSDQ 975
               .|..::......:.|::..     ..|.:........:...|..|....:..:.|  .:..:
Mouse  1288 ---PNAEQALLHLPFTMVAEQK-----RLDDILRNLSQQPEELRDLYSKHLVAQLAQDIFRSHLE 1344

  Fly   976 TTETTPESSTDSTESSTLDASSTTDASSTSESSSESSTDGSSTTSNSASSETTGLSSDGSTTDAT 1040
            ..:..|:.|........:.|.......|:|..||.....|.|...:...:....:|       |.
Mouse  1345 NQDLLPKPSEQRFPPMAVPAHKHVSGFSSSLRSSSGEAGGGSRRPHRKPAILRKIS-------AA 1402

  Fly  1041 TAASDNTDITTDGSTDESTDGSSNASTEGSTEGASEDTTISTESSGSTESTDAI--ASDGSTTEG 1103
            ...|.:..:|..|.|.....|:.:........|....|...|.:..:.:.:|.|  ..|.|....
Mouse  1403 QQLSASEVVTHLGQTVALASGTLSVLLHCEAVGNPRPTIHWTRNGEAVQFSDRILLQPDDSLQIL 1467

  Fly  1104 STVE--------DLSSSTSSDVTSDSTITDSSPSTEVSGSTDSSSSTDGSSTDASSTEASSTDVT 1160
            :.||        :.:::...|..|.:......|..:.|..|..::.....:.|...|..:...|.
Mouse  1468 APVEADVGFYTCNATNALGYDSVSIAVTLAGKPLVKTSRMTVLNTEKPTVTVDIGGTVRTVRGVN 1532

  Fly  1161 ESTDSTVSGGTSDTTESGPT--EESTTEGSTESTTEGST-----DSTQSTDLDSTTSDIWSTSDK 1218
            .:.:..|:|    ..|:..|  ...:..||:....|||:     .|...||:..:...::|....
Mouse  1533 VTINCQVAG----VPEAEVTWFRNKSKLGSSHHLHEGSSHHLHEGSLLLTDVSFSDQGLYSCRAA 1593

  Fly  1219 D---DESESSTPYSFDSEVTKSKPRKCK-------PKKSTCAKSEYGC-------------CP-D 1259
            :   :::||:.....|.....::....:       |...:...|..|.             || .
Mouse  1594 NLHGEQTESTQLLILDPPQVPTQLEDIRALLLATGPNLPSVLMSPLGTQLVLDPGNSALLGCPIK 1658

  Fly  1260 GKSTPKGP-FDEGCPIAKTCADTKY----GCCLDGVSPAKGKNNKGCPKSQCAETLFGCCPDKFT 1319
            |..||... |..|.|||.....|.:    |..|      :..|..|.|:.:     |.|.     
Mouse  1659 GHPTPNITWFQNGQPIATAPGLTHHIWGAGQIL------RVANLSGGPQGE-----FSCL----- 1707

  Fly  1320 AADGENDEG----------------------CP-----------------ETTTVPPTTTTEE-- 1343
               .:|:.|                      |.                 .||.|.|...|.:  
Mouse  1708 ---AQNEAGTLLQKASLVIQDYWWSVDRLATCSASCGNRGIHQPRLRCLLNTTEVDPEHCTGKPR 1769

  Fly  1344 --TQPETTTEIEGSGQDSTTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGCGLASPVAKGCAES 1406
              .||......:...:...||.....:||.   .|......|..|   .:..|:::||      |
Mouse  1770 PAVQPVACNRRDCPSRWMVTSWSACTRSCG---GGVQTRRVTCQK---LKASGISTPV------S 1822

  Fly  1407 ENGCCPDGQTPASGPNGEGCSG--CTRERFGCCPDSQTPAHGP------------NKEGCCLDTQ 1457
            .:.|....:.|.   :.:.|:.  |....|........|..||            .::|..|.::
Mouse  1823 NDMCSQLAKRPV---DTQACNQQLCVEWAFSSWGQCNGPCIGPRLAVQHRQVFCQTRDGITLPSE 1884

  Fly  1458 FGCCPDNILAARGPNNEGCECHY--TPYGCCPDNKSAAT----GYNQEGCACETTQYGCCPDKIT 1516
            ........::.:...:|.|..|:  :.:..|     .||    |:......|...:......:..
Mouse  1885 QCSALPRPVSTQNCWSEACSVHWRVSLWTLC-----TATCGNYGFQSRRVECVHVRTNKAVPEHL 1944

  Fly  1517 AAKGPK---HEGC---PCETTQFGCCPDGLTFA-KGPHHHGCHCTQTEFKCC 1561
            .:.||:   .:.|   |||.|:   |.|...:. |......|...|...:||
Mouse  1945 CSWGPRPANWQRCNVTPCENTE---CRDTTRYCEKVRQLKLCQLGQFRSRCC 1993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 23/50 (46%)
ADAMTS_CR_3 116..213 CDD:437068 50/97 (52%)
ADAMTS_spacer1 222..329 CDD:461796 23/109 (21%)
TSP1_ADAMTS 347..396 CDD:465950 19/57 (33%)
TSP1_ADAMTS 400..457 CDD:465950 17/56 (30%)
TSP1_ADAMTS 465..520 CDD:465950 17/142 (12%)
TSP1_ADAMTS 580..632 CDD:465950 18/54 (33%)
TSP1_ADAMTS 643..693 CDD:465950 14/52 (27%)
MSCRAMM_ClfA <1049..1262 CDD:468110 43/253 (17%)
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
Adamtsl1XP_006538438.1 TSP1 265..311 CDD:214559 24/52 (46%)
ADAMTS_CR_3 316..414 CDD:437068 50/97 (52%)
ADAMTS_spacer1 433..525 CDD:461796 21/107 (20%)
TSP1_ADAMTS 530..588 CDD:465950 20/62 (32%)
TSP1_ADAMTS 609..666 CDD:465950 18/61 (30%)
TSP1_ADAMTS 669..721 CDD:465950 10/51 (20%)
TSP1_ADAMTS 760..812 CDD:465950 7/51 (14%)
TSP1_ADAMTS 840..895 CDD:465950 0/54 (0%)
TSP1_ADAMTS 899..957 CDD:465950 16/57 (28%)
TSP1_ADAMTS 961..1017 CDD:465950 19/61 (31%)
TSP1_ADAMTS 1021..1078 CDD:465950 19/74 (26%)
Ig 1124..1178 CDD:409353 11/57 (19%)
Ig strand B 1124..1128 CDD:409353 0/7 (0%)
Ig strand C 1137..1141 CDD:409353 1/3 (33%)
Ig strand E 1159..1163 CDD:409353 0/3 (0%)
Ig strand F 1173..1178 CDD:409353 2/4 (50%)
Ig <1426..1486 CDD:472250 9/59 (15%)
Ig strand B 1427..1431 CDD:409358 0/3 (0%)
Ig strand C 1440..1444 CDD:409358 1/3 (33%)
Ig strand E 1462..1466 CDD:409358 1/3 (33%)
Ig strand F 1476..1481 CDD:409358 0/4 (0%)
Ig_3 1514..1594 CDD:464046 16/83 (19%)
Ig 1632..1723 CDD:472250 22/109 (20%)
Ig strand B 1651..1655 CDD:409353 0/3 (0%)
Ig strand C 1664..1668 CDD:409353 0/3 (0%)
Ig strand E 1686..1693 CDD:409353 2/12 (17%)
Ig strand F 1703..1708 CDD:409353 2/17 (12%)
Ig strand G 1716..1719 CDD:409353 0/2 (0%)
TSP1_ADAMTS 1786..1844 CDD:465950 14/72 (19%)
TSP1_ADAMTS 1847..1903 CDD:465950 7/55 (13%)
TSP1_ADAMTS 1907..1962 CDD:465950 8/59 (14%)
PLAC 1967..1996 CDD:462560 7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.