Protein Alignment Ppn and SPINT1

DIOPT Version :10

• Sequence 1: NP_788752.2
• Gene: Ppn / 43872
• FlyBaseID: FBgn0003137
• Length: 2898
• Species: Drosophila melanogaster
• Sequence 2: NP_857593.1
• Gene: SPINT1 / 6692
• HGNCID: 11246
• Length: 529
• Species: Homo sapiens
• Alignment Length: 223
• Identity: 67/223 - (30%)
• Similarity: 91/223 - (40%)
• Gaps: 59/223 - (26%)

  Fly  1713 SLEQCQGTCAASENLPTCEQPVESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPTEHACN 1777
            |.:|.:..|.||..:         |.|.|:|.|||||....||:.|.||||.||||||..|..|.
Human   242 STKQTEDYCLASNKV---------GRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECI 297

  Fly  1778 YNCR--QPGVLKDRC----------ALPKQTGDCSEKLAKWHFSESEKRCVPFYYSGCGGNKNNF 1830
            ..||  |.|.|:...          ::.::...||.......|..|...|:..:
Human   298 LACRGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSF----------- 351

  Fly  1831 PTLESCED--HCPRQVAKDICE-------------IPAEVGECANY---------VTSWYYDTQD 1871
              || |:|  :||....:..||             .|::.|.|.:.         :..|||:...
Human   352 --LE-CDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFS 413

  Fly  1872 QACRQFYYGGCGGNENRFPTEESCLARC 1899
            :.|.:|.||||.||:|.|..|:.||..|
Human   414 EHCARFTYGGCYGNKNNFEEEQQCLESC 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAMTS_CR_3	116..213	CDD:437068
		ADAMTS_spacer1	222..329	CDD:461796
		TSP1_ADAMTS	347..396	CDD:465950
		TSP1_ADAMTS	400..457	CDD:465950
		TSP1_ADAMTS	465..520	CDD:465950
		TSP1_ADAMTS	580..632	CDD:465950
		TSP1_ADAMTS	643..693	CDD:465950
		MSCRAMM_ClfA	<1049..1262	CDD:468110
		Kunitz_papilin_lacunin-like	1612..1663	CDD:438681
		Kunitz_BPTI	1670..1721	CDD:425421	2/7 (29%)
		Kunitz-type	1730..1780	CDD:438633	24/49 (49%)
		Kunitz_BPTI	1789..1840	CDD:425421	9/62 (15%)
		Kunitz_papilin_mig6-like	1849..1899	CDD:438679	21/71 (30%)
		Kunitz_papilin_mig6-like	1922..1972	CDD:438679
		Kunitz_papilin_mig6-like	2001..2051	CDD:438679
		Kunitz-type	2071..2121	CDD:438633
		Kunitz_BPTI	2127..2178	CDD:425421
		Kunitz_BPTI	2193..2245	CDD:425421
		Kunitz_BPTI	2252..2303	CDD:425421
		Kunitz_BPTI	2317..2372	CDD:425421
		WAP	2455..2497	CDD:459672
		Ig	2530..2610	CDD:472250
		Ig strand B	2539..2543	CDD:409353
		Ig strand C	2552..2556	CDD:409353
		Ig strand E	2576..2579	CDD:409353
		Ig strand F	2589..2594	CDD:409353
		Ig strand G	2603..2606	CDD:409353
		IG_like	2627..2703	CDD:214653
		Ig strand B	2636..2640	CDD:409353
		Ig strand C	2649..2653	CDD:409353
		Ig strand E	2670..2674	CDD:409353
		Ig strand F	2684..2689	CDD:409353
		Ig strand G	2697..2700	CDD:409353
		I-set	2766..2845	CDD:400151
		Ig strand B	2771..2775	CDD:409353
		Ig strand C	2784..2788	CDD:409353
		Ig strand F	2821..2826	CDD:409353
		PLAC	2851..2883	CDD:462560
SPINT1	NP_857593.1	MANEC	50..139	CDD:462186
		Kunitz_HAI1_1-like	245..303	CDD:438666	30/66 (45%)
		LDLa	334..366	CDD:197566	9/45 (20%)
		Kunitz_HAI1_2-like	390..450	CDD:438667	18/52 (35%)