DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and Aplp2

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_037038.1	Gene:	Aplp2 / 64312	RGDID:	2128	Length:	765	Species:	Rattus norvegicus

Alignment Length:	361	Identity:	80/361 - (22%)
Similarity:	115/361 - (31%)	Gaps:	117/361 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1684 TKKWYFDVDRNRCEEFQYGGCYGTNNRFDSLEQCQGTCAASE--NLPTCEQPVESGPCAGNFERW 1746
            |.||..|....:       .|.||..  :.|:.||......:  |:....|||       |.:.|
  Rat    67 TGKWEPDPTGTK-------SCLGTKE--EVLQYCQEIYPELQITNVMEANQPV-------NIDSW 115

  Fly  1747 ------------------------------------YYDNETDICRP------------------ 1757
                                                ::....::|..
  Rat   116 CRRDKKQCRSHIVIPFKCLVGEFVSDVLLVPENCQFFHQERMEVCEKHQRWHTVVKEACLTEGMT 180

  Fly  1758 -FTYG---GCKGNKNNYPTEHACNYNCRQPGVLKDRCALPKQTGDCSEKLAKWHFSESEKRCVPF 1818
             ::||   .| |....:.||:.|   |.|..|:.....:.|:..:..|:      .|.|...:
  Rat   181 LYSYGMLLPC-GVDQFHGTEYVC---CPQTKVVDSDSTMSKEEEEEEEE------DEEEDYAL-- 233

  Fly  1819 YYSGCGGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYV--TSWYYDTQDQACRQFYYGG 1881
                   :|:.|||....||.......:|..|...|..|....|  ..:|||:         :.|
  Rat   234 -------DKSEFPTEADLEDFTEAAADEDEDEEEEEEEEGEEVVEDRDYYYDS---------FKG 282

  Fly  1882 CGGNENRFPTEESCLARCDRKPEPTTTTPATRPQPSRQDVCDEEPAPGECSTWVLKWHFDRKIGA 1946
            ...||.. |||          |....|..........:.||.:|...|.|...:.:|:||...|.
  Rat   283 DDYNEEN-PTE----------PSSDGTISDKEIAHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGK 336

  Fly  1947 CRQFYYGNCGGNGNRFETENDCQQRCLSQEPPAPTP 1982
            |.:|.||.||||.|.||:|:.|...|.:..||.|.|
  Rat   337 CVRFIYGGCGGNRNNFESEDYCMAVCKTMIPPTPLP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443	10/36 (28%)
		Kunitz_BPTI	1729..1781	CDD:278443	13/109 (12%)
		Kunitz_BPTI	1789..1840	CDD:278443	10/50 (20%)
		Kunitz_BPTI	1848..1899	CDD:278443	13/52 (25%)
		KU	1920..1973	CDD:238057	22/52 (42%)
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Aplp2	NP_037038.1	A4_EXTRA	42..204	CDD:128326	24/156 (15%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	46..139		16/87 (18%)
		APP_N	49..147	CDD:280358	16/95 (17%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	147..205		9/61 (15%)
		APP_Cu_bd	149..204	CDD:289676	8/58 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..301		26/124 (21%)
		Kunitz_BPTI	311..363	CDD:278443	22/51 (43%)
		APP_E2	367..549	CDD:289677	4/6 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..616
		APP_amyloid	711..761	CDD:287486
		Interaction with DAB2. /evidence=ECO:0000250	751..765
		NPXY motif	752..757
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9558
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810