DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and PTK7

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001257327.1	Gene:	PTK7 / 5754	HGNCID:	9618	Length:	1078	Species:	Homo sapiens

Alignment Length:	786	Identity:	166/786 - (21%)
Similarity:	241/786 - (30%)	Gaps:	316/786 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  2304 LAGRE----PRVGSAKEICLLPVATGRCNGPSVHERRWYYDDEAGNCVSFIYAGCSGNQNNFRSF 2364
            |:|.:    |.||||.|....|...||. ||...           ..:.||
Human     5 LSGEKRPSAPTVGSAMEKKEFPTPPGRV-GPGTQ-----------TAIVFI-------------- 43

  Fly  2365 EACTNQCRPEPNKQDNEIGQNPCDTFDAECQELRCPYGVRRVAARSQPECTQCICENPCEGYSCP 2429
                    .:|:.||...|                    ||...|.:.|     ...|...|...
Human    44 --------KQPSSQDALQG--------------------RRALLRCEVE-----APGPVHVYWLL 75

  Fly  2430 EG-----------QQCAIDVASSDDRQ----FAPVCRDIYKPGECPALSANAS------------ 2467
            :|           |..::..|:.|..|    |..|.||.....|  |.|||||
Human    76 DGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEE--ARSANASFNIKWIEAGPVV 138

  Fly  2468 --------------GCARECYTDADCRGDNKCCSDGC----GQ-----------LCVHPARPT-- 2501
                          .....|:.|...|...:...||.    ||           |.:.||.|.
Human   139 LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHS 203

  Fly  2502 ------------QPPRTQAPVVSYPGD--ARAALEPKEAHELDVQTAIGGIAVLRCFATGNPAPN 2552
                        |...:|...:|...:  ||..|.|:     ||..|....|:..|..:..|.|:
Human   204 GLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQ-----DVVVARYEEAMFHCQFSAQPPPS 263

  Fly  2553 ITWSLKNLVINTNKG------RYVLTANGDLTIVQVRQTDDGTYVCVASNGLGEPVRREVALQVT 2611
            :.|..::....||:.      |..:.|||.|.:.|||..:.|.|.|:.....|.|:..|..|.:.
Human   264 LQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLA 328

  Fly  2612 E----PVSQP-AYIYG-DKNVTQIVELNRPAVIRCPAGGFPEPHVSWWRNGQMFGLKNNLMARDY 2670
            |    |:.:| .:..| ::.||.:           |..|.|||.|.|...|........:..:.:
Human   329 EIEDMPLFEPRVFTAGSEERVTCL-----------PPKGLPEPSVWWEHAGVRLPTHGRVYQKGH 382

  Fly  2671 SLVFNSIQLSDLGLYTCEVYN---QRR-------------------------------------- 2694
            .||..:|..||.|:|||...|   |||
Human   383 ELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATP 447

  Fly  2695 -PV----------------------SLRV--------------------TLKAVGPVRPLS---- 2712
             |.                      :||:                    :::|...|:.|.
Human   448 KPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKF 512

  Fly  2713 ---PEEEQYMQYVLNPATRPVT----QRPSYPYRPTRPAYVPE---------------------- 2748
               |:.:|.|::. ..||.|.:    ::|:..:.....:.:||
Human   513 TPPPQPQQCMEFD-KEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNY 576

  Fly  2749 -------P----------TVNVHAVLALEP-KNSYTPGSTIVMSCSVQGYPEPNVTWI-KDDV-- 2792
                   |          ||.|.....:|| :.:...|.|.::.|..||.|:|.:.|. ||.:
Human   577 TCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILD 641

  Fly  2793 PLYNNERVQITYQPHRLVLSDVTSADSGKYTCRASNAYTYANGEANVSI-------QSVVPVSPE 2850
            |.....|:.| :|...||:.||...|||:|||.|.|:....:.||.:.:       :|..|.||.
Human   642 PTKLGPRMHI-FQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPP 705

  Fly  2851 CVDNPY 2856
                ||
Human   706 ----PY 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057	166/786 (21%)
		KU	2316..2372	CDD:238057	8/55 (15%)
		WAP	2457..2497	CDD:278522	15/80 (19%)
		Ig	2521..2610	CDD:299845	27/94 (29%)
		IG_like	2530..2610	CDD:214653	25/85 (29%)
		IG_like	2627..2703	CDD:214653	25/159 (16%)
		Ig	2636..2701	CDD:143165	24/148 (16%)
		IG_like	2766..2841	CDD:214653	28/77 (36%)
		Ig	2768..2830	CDD:299845	26/64 (41%)
		PLAC	2851..2883	CDD:285849	2/6 (33%)
PTK7	NP_001257327.1	IG_like	46..120	CDD:214653	20/100 (20%)
		IGc2	53..113	CDD:197706	14/84 (17%)
		Ig2_PTK7	154..230	CDD:143237	14/75 (19%)
		IG_like	239..>309	CDD:214653	21/74 (28%)
		Ig	250..310	CDD:143165	17/59 (29%)
		IG	348..416	CDD:214652	23/78 (29%)
		IGc2	348..406	CDD:197706	20/68 (29%)
		I-set	420..506	CDD:254352	5/85 (6%)
		Ig	422..506	CDD:299845	5/83 (6%)
		I-set	511..596	CDD:254352	10/85 (12%)
		IGc2	528..582	CDD:197706	6/53 (11%)
		IG_like	606..689	CDD:214653	29/83 (35%)
		IGc2	613..677	CDD:197706	25/64 (39%)
		PTK_CCK4	798..1071	CDD:133178
		STYKc	809..1069	CDD:214568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900