DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and ADAMTSL3

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_011520124.1 Gene:ADAMTSL3 / 57188 HGNCID:14633 Length:1718 Species:Homo sapiens


Alignment Length:1773 Identity:397/1773 - (22%)
Similarity:605/1773 - (34%) Gaps:504/1773 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 VLASIHDSQSRFPGLRQKRQYGANMYLPESSVTPGGE-----------------------GNDPD 58
            ||..:....|..|....::..|| .:|||.:::|.|.                       .:|.|
Human    10 VLIGMVFMHSPLPQTTAEKSPGA-YFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNTRSDED 73

  Fly    59 E---WTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQ 120
            :   |..|...||||||||||.||..|.||...:     |.|.:.||.:|:..|||.:..|||||
Human    74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRN-----CEGQNIRYKTCSNHDCPPDAEDFRAQ 133

  Fly   121 QCSRFDRQQFDGVFYEWVPYTNAP-NPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGE 184
            |||.::..|:.|.:|||:|..|.| .||.|.|..:|:........||:||||||...||:|::|.
Human   134 QCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGI 198

  Fly   185 CMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIR-------NTITTKDLAPGY------------- 229
            |..||||..|||:||||.|..|.||||||:.:|       :...|..|.||.             
Human   199 CQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKTPGLPPGQGGPLPGGHLSAIY 263

  Fly   230 --------NDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNY 286
                    .:::.:|.|:.::||....|:..::..:...|.   .|:...:.|......|:...:
Human   264 EWPILKGEENVIAVPLGSRSVRITVKGPAHLFIESKTLQGS---KGEHSFNSPGVFLVENTTVEF 325

  Fly   287 QR-------------------KPMGFAAPDQ-----------------------LTCSGPISESL 309
            ||                   |....||.|.                       :||.|....:.
Human   326 QRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNS 390

  Fly   310 FIVMLVQEKNISLD-YEYSIPESLSHSQ-------------------------QDTHTWTHHQFN 348
            ...:.::.|.:..| |.:..||::....                         |....|.|:.:.
Human   391 AECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWT 455

  Fly   349 ACSASCGGGSQSRKVTC---NNRITLAEVNPSLCDQKSKPVEEQACGTEPCAPHWVEGEWSKCSK 410
            |||.|||||.|.|...|   :....:.:|....|....||...|.|....| |.|:..|||:|:.
Human   456 ACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQCTV 519

  Fly   411 GCGSDGFQNRSITCERISSSGEHT----------VEEDAV----CLKEVGNKP----------AT 451
            .||. |.:.|.:.|  |:..|||.          ::|:.|    |.|.....|          |.
Human   520 TCGR-GLRYRVVLC--INHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQ 581

  Fly   452 KQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTC--FIEENGHKRVLPEEDCVEEKPETEKS 514
            :.|..|.....|.:...||:.|...||.|.|.|:|.|  .:.....:..||||:|...|..||:.
Human   582 ELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERP 646

  Fly   515 CLLTPCE------------------GVDWIISQWSGCNACGQNTETRTAICGNKEG--------- 552
            |||..|:                  ..||   :::|...|     |.|.:.|::|.         
Human   647 CLLEACDESPASRELDIPLPEDSETTYDW---EYAGFTPC-----TATCVGGHQEAIAVCLHIQT 703

  Fly   553 -KVYPEEFCE--PEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVIC---GEFDGKTV 611
             :...:..|:  ...|.:|:.|.:..|..:|....|..|||.||.|:::|.|.|   ||      
Human   704 QQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGE------ 762

  Fly   612 TPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLC---------- 666
            |||..: :|..| ||.:.|.|...:  ||..|....|.:||:.||||.:.|.|.|          
Human   763 TPAPPE-ECRDE-KPHALQACNQFD--CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFL 823

  Fly   667 -----LSNGTK------------------------SVNCD---------------EEKVEPLSEK 687
                 |..|.|                        ||:|.               :.:..||||.
Human   824 NLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEM 888

  Fly   688 CNSEACTEDEILPLTST------DKPIEDDEEDCDEDGIELIS-DGLSDDEKSEDVIDLEGTAKT 745
                .|.:...|||..:      .|...:.:....|.|.:::| ..:....:.|..|:|...::.
Human   889 ----MCRDLPGLPLVRSCQMPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRA 949

  Fly   746 ETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDSESTTDSGISTEGS----------------- 793
            ...|....:::    .|...|:.:...:|..|...:::...||:..||                 
Human   950 YLLPNTSVIIK----CPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGSLKIHGLAAPDIGVYRCI 1010

  Fly   794 -GDDEET------------------------------SEAST----------------DLSSSTD 811
             |..:||                              |||::                ||....|
Human  1011 AGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDDD 1075

  Fly   812 SGSTSS------DSTSSDSSSSISSDATSEAPASSVSDSSDSTDAS------------TETTGVS 858
            ..|...      ...|:.:.|:.|.:..::...::|...:.|.|.:            .||..||
Human  1076 HISNQPFLRALLGHCSNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQFDELIRNMSQLMETGEVS 1140

  Fly   859 DDSTDVSSS------TEASASESTDVS--GASDSTGSTNASDSTPESSTEASSSTDDSTDSSDNS 915
            |   |::|.      .|.:.::.|.:.  |..:.|        .|.:.....:.:...:..:.||
Human  1141 D---DLASQLIYQLVAELAKAQPTHMQWRGIQEET--------PPAAQLRGETGSVSQSSHAKNS 1194

  Fly   916 SN--------VSESSTEASSSSVSDSNDSSDGSTDGVSSTTE---------NSSDSTSDATSDST 963
            ..        |....::..|.|.:.:.:|..|:|..::..||         ..|::|...|.|.|
Human  1195 GKLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSEATYTWTKDGT 1259

  Fly   964 ASSDSTDSTSDQTTETTPESSTDSTESSTLDASSTTDASSTSESSSESSTDGS---STTSNSASS 1025
            ....|.....|.|.:...::.| ..|....:.|......|..||||....:..   |...|....
Human  1260 LLQPSVKIILDGTGKIQIQNPT-RKEQGIYECSVANHLGSDVESSSVLYAEAPVILSVERNITKP 1323

  Fly  1026 ETTGLS-SDGSTTDATTAAS----------DNTDIT-------TDGSTDESTDGS---SNASTEG 1069
            |...|| ..|...:|...|:          ...:||       ..|:.....:||   .|.|.| 
Human  1324 EHNHLSVVVGGIVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLE- 1387

  Fly  1070 STEGASEDTTISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSSDVTSDSTITDSS-PSTE-- 1131
             .||..  ..|:|.:.|...:|..:.........|.:..|.......:.:.:|.|:|: |:.|  
Human  1388 -NEGTY--VCIATNALGKAVATSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPP 1449

  Fly  1132 ------VSGSTDSSSSTDG---------SSTDASSTEASSTDVTESTDSTVSGGTSDTTESGPTE 1181
                  ..|:....|:|.|         ....|:..|.|.. :.:.....::|.........|..
Human  1450 PQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEA-LCDHLQKPLAGFEPCNIRDCPAR 1513

  Fly  1182 ESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKCKPKK 1246
            ..|:..|..|.:.|....::......|.:                    :..|....||.|.||.
Human  1514 WFTSVWSQCSVSCGEGYHSRQVTCKRTKA--------------------NGTVQVVSPRACAPKD 1558

  Fly  1247 ----------STCAKSEYG-CCPD---GKSTPKGPFDEGCPIAKTCADTKYGCCLDGVSPAKGKN 1297
                      ..|.:.|.| .||.   |::.........|  ....:|:.   |.|...|...:|
Human  1559 RPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTAC--QHNSSDSN---CDDRKRPTLRRN 1618

  Fly  1298 NKGCPKSQCAETLFGCCPDK-FTAADGENDEG----CPETTTVPPTT---TTEETQPETTTEIEG 1354
               |....| :..:...|.| .|||.|...:.    |..|.:..|..   ..::.:|.:.....|
Human  1619 ---CTSGAC-DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLG 1679

  Fly  1355 SGQDSTTSEPDTKKSCSF 1372
            ...|...:  ||...|.|
Human  1680 PSCDRDCT--DTTHYCMF 1695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 23/50 (46%)
ADAM_spacer1 214..329 CDD:283607 26/185 (14%)
TSP1 468..521 CDD:214559 21/54 (39%)
TSP_1 645..693 CDD:278517 20/101 (20%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
ADAMTSL3XP_011520124.1 TSP1 78..124 CDD:214559 23/50 (46%)
TSP1 453..>473 CDD:214559 10/19 (53%)
TSP1 513..>542 CDD:214559 13/31 (42%)
TSP1 598..>618 CDD:214559 9/19 (47%)
TSP1 734..787 CDD:214559 22/62 (35%)
TSP1 790..847 CDD:214559 14/56 (25%)
TSP1 853..908 CDD:214559 11/58 (19%)
Ig 956..1020 CDD:299845 11/67 (16%)
Ig 1238..1302 CDD:143165 12/64 (19%)
IG_like 1336..1410 CDD:214653 16/77 (21%)
IGc2 1341..1401 CDD:197706 13/63 (21%)
TSP_1 1516..1571 CDD:301595 11/74 (15%)
PLAC 1686..1716 CDD:285849 4/12 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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