DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and ADAMTSL3

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_011520124.1 Gene:ADAMTSL3 / 57188 HGNCID:14633 Length:1718 Species:Homo sapiens


Alignment Length:1773 Identity:397/1773 - (22%)
Similarity:605/1773 - (34%) Gaps:504/1773 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 VLASIHDSQSRFPGLRQKRQYGANMYLPESSVTPGGE-----------------------GNDPD 58
            ||..:....|..|....::..|| .:|||.:::|.|.                       .:|.|
Human    10 VLIGMVFMHSPLPQTTAEKSPGA-YFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNTRSDED 73

  Fly    59 E---WTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQ 120
            :   |..|...||||||||||.||..|.||...:     |.|.:.||.:|:..|||.:..|||||
Human    74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRN-----CEGQNIRYKTCSNHDCPPDAEDFRAQ 133

  Fly   121 QCSRFDRQQFDGVFYEWVPYTNAP-NPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGE 184
            |||.::..|:.|.:|||:|..|.| .||.|.|..:|:........||:||||||...||:|::|.
Human   134 QCSAYNDVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGI 198

  Fly   185 CMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIR-------NTITTKDLAPGY------------- 229
            |..||||..|||:||||.|..|.||||||:.:|       :...|..|.||.             
Human   199 CQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKTPGLPPGQGGPLPGGHLSAIY 263

  Fly   230 --------NDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNY 286
                    .:::.:|.|:.::||....|:..::..:...|.   .|:...:.|......|:...:
Human   264 EWPILKGEENVIAVPLGSRSVRITVKGPAHLFIESKTLQGS---KGEHSFNSPGVFLVENTTVEF 325

  Fly   287 QR-------------------KPMGFAAPDQ-----------------------LTCSGPISESL 309
            ||                   |....||.|.                       :||.|....:.
Human   326 QRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNS 390

  Fly   310 FIVMLVQEKNISLD-YEYSIPESLSHSQ-------------------------QDTHTWTHHQFN 348
            ...:.::.|.:..| |.:..||::....                         |....|.|:.:.
Human   391 AECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWT 455

  Fly   349 ACSASCGGGSQSRKVTC---NNRITLAEVNPSLCDQKSKPVEEQACGTEPCAPHWVEGEWSKCSK 410
            |||.|||||.|.|...|   :....:.:|....|....||...|.|....| |.|:..|||:|:.
Human   456 ACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQCTV 519

  Fly   411 GCGSDGFQNRSITCERISSSGEHT----------VEEDAV----CLKEVGNKP----------AT 451
            .||. |.:.|.:.|  |:..|||.          ::|:.|    |.|.....|          |.
Human   520 TCGR-GLRYRVVLC--INHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQ 581

  Fly   452 KQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTC--FIEENGHKRVLPEEDCVEEKPETEKS 514
            :.|..|.....|.:...||:.|...||.|.|.|:|.|  .:.....:..||||:|...|..||:.
Human   582 ELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERP 646

  Fly   515 CLLTPCE------------------GVDWIISQWSGCNACGQNTETRTAICGNKEG--------- 552
            |||..|:                  ..||   :::|...|     |.|.:.|::|.         
Human   647 CLLEACDESPASRELDIPLPEDSETTYDW---EYAGFTPC-----TATCVGGHQEAIAVCLHIQT 703

  Fly   553 -KVYPEEFCE--PEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVIC---GEFDGKTV 611
             :...:..|:  ...|.:|:.|.:..|..:|....|..|||.||.|:::|.|.|   ||      
Human   704 QQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGE------ 762

  Fly   612 TPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLC---------- 666
            |||..: :|..| ||.:.|.|...:  ||..|....|.:||:.||||.:.|.|.|          
Human   763 TPAPPE-ECRDE-KPHALQACNQFD--CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFL 823

  Fly   667 -----LSNGTK------------------------SVNCD---------------EEKVEPLSEK 687
                 |..|.|                        ||:|.               :.:..||||.
Human   824 NLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEM 888

  Fly   688 CNSEACTEDEILPLTST------DKPIEDDEEDCDEDGIELIS-DGLSDDEKSEDVIDLEGTAKT 745
                .|.:...|||..:      .|...:.:....|.|.:::| ..:....:.|..|:|...::.
Human   889 ----MCRDLPGLPLVRSCQMPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRA 949

  Fly   746 ETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDSESTTDSGISTEGS----------------- 793
            ...|....:::    .|...|:.:...:|..|...:::...||:..||                 
Human   950 YLLPNTSVIIK----CPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGSLKIHGLAAPDIGVYRCI 1010

  Fly   794 -GDDEET------------------------------SEAST----------------DLSSSTD 811
             |..:||                              |||::                ||....|
Human  1011 AGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDDD 1075

  Fly   812 SGSTSS------DSTSSDSSSSISSDATSEAPASSVSDSSDSTDAS------------TETTGVS 858
            ..|...      ...|:.:.|:.|.:..::...::|...:.|.|.:            .||..||
Human  1076 HISNQPFLRALLGHCSNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQFDELIRNMSQLMETGEVS 1140

  Fly   859 DDSTDVSSS------TEASASESTDVS--GASDSTGSTNASDSTPESSTEASSSTDDSTDSSDNS 915
            |   |::|.      .|.:.::.|.:.  |..:.|        .|.:.....:.:...:..:.||
Human  1141 D---DLASQLIYQLVAELAKAQPTHMQWRGIQEET--------PPAAQLRGETGSVSQSSHAKNS 1194

  Fly   916 SN--------VSESSTEASSSSVSDSNDSSDGSTDGVSSTTE---------NSSDSTSDATSDST 963
            ..        |....::..|.|.:.:.:|..|:|..::..||         ..|::|...|.|.|
Human  1195 GKLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSEATYTWTKDGT 1259

  Fly   964 ASSDSTDSTSDQTTETTPESSTDSTESSTLDASSTTDASSTSESSSESSTDGS---STTSNSASS 1025
            ....|.....|.|.:...::.| ..|....:.|......|..||||....:..   |...|....
Human  1260 LLQPSVKIILDGTGKIQIQNPT-RKEQGIYECSVANHLGSDVESSSVLYAEAPVILSVERNITKP 1323

  Fly  1026 ETTGLS-SDGSTTDATTAAS----------DNTDIT-------TDGSTDESTDGS---SNASTEG 1069
            |...|| ..|...:|...|:          ...:||       ..|:.....:||   .|.|.| 
Human  1324 EHNHLSVVVGGIVEAALGANVTIRCPVKGVPQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLE- 1387

  Fly  1070 STEGASEDTTISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSSDVTSDSTITDSS-PSTE-- 1131
             .||..  ..|:|.:.|...:|..:.........|.:..|.......:.:.:|.|:|: |:.|  
Human  1388 -NEGTY--VCIATNALGKAVATSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPP 1449

  Fly  1132 ------VSGSTDSSSSTDG---------SSTDASSTEASSTDVTESTDSTVSGGTSDTTESGPTE 1181
                  ..|:....|:|.|         ....|:..|.|.. :.:.....::|.........|..
Human  1450 PQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEA-LCDHLQKPLAGFEPCNIRDCPAR 1513

  Fly  1182 ESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKCKPKK 1246
            ..|:..|..|.:.|....::......|.:                    :..|....||.|.||.
Human  1514 WFTSVWSQCSVSCGEGYHSRQVTCKRTKA--------------------NGTVQVVSPRACAPKD 1558

  Fly  1247 ----------STCAKSEYG-CCPD---GKSTPKGPFDEGCPIAKTCADTKYGCCLDGVSPAKGKN 1297
                      ..|.:.|.| .||.   |::.........|  ....:|:.   |.|...|...:|
Human  1559 RPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTAC--QHNSSDSN---CDDRKRPTLRRN 1618

  Fly  1298 NKGCPKSQCAETLFGCCPDK-FTAADGENDEG----CPETTTVPPTT---TTEETQPETTTEIEG 1354
               |....| :..:...|.| .|||.|...:.    |..|.:..|..   ..::.:|.:.....|
Human  1619 ---CTSGAC-DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLG 1679

  Fly  1355 SGQDSTTSEPDTKKSCSF 1372
            ...|...:  ||...|.|
Human  1680 PSCDRDCT--DTTHYCMF 1695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 23/50 (46%)
ADAMTS_CR_3 116..213 CDD:437068 51/97 (53%)
ADAMTS_spacer1 222..329 CDD:461796 25/170 (15%)
TSP1_ADAMTS 347..396 CDD:465950 17/51 (33%)
TSP1_ADAMTS 400..457 CDD:465950 21/80 (26%)
TSP1_ADAMTS 465..520 CDD:465950 21/56 (38%)
TSP1_ADAMTS 580..632 CDD:465950 21/54 (39%)
TSP1_ADAMTS 643..693 CDD:465950 21/103 (20%)
MSCRAMM_ClfA <1049..1262 CDD:468110 47/254 (19%)
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
ADAMTSL3XP_011520124.1 TSP1 78..124 CDD:214559 23/50 (46%)
ADAMTS_CR_3 129..227 CDD:437068 51/97 (53%)
TSP1_ADAMTS 370..428 CDD:465950 8/57 (14%)
TSP1_ADAMTS 449..506 CDD:465950 19/56 (34%)
TSP1_ADAMTS 509..561 CDD:465950 16/54 (30%)
TSP1_ADAMTS 597..652 CDD:465950 21/54 (39%)
TSP1_ADAMTS 675..730 CDD:465950 11/62 (18%)
TSP1_ADAMTS 734..786 CDD:465950 22/61 (36%)
TSP1_ADAMTS 790..846 CDD:465950 14/55 (25%)
TSP1_ADAMTS 852..907 CDD:465950 11/58 (19%)
Ig <956..1020 CDD:472250 11/67 (16%)
Ig strand B 957..961 CDD:409353 0/7 (0%)
Ig strand C 970..974 CDD:409353 0/3 (0%)
Ig strand E 992..996 CDD:409353 2/3 (67%)
Ig strand F 1006..1011 CDD:409353 0/4 (0%)
Ig strand G 1015..1018 CDD:409353 1/2 (50%)
Ig 1238..1303 CDD:409353 13/65 (20%)
Ig strand B 1238..1242 CDD:409353 0/3 (0%)
Ig strand C 1251..1255 CDD:409353 1/3 (33%)
Ig strand E 1273..1277 CDD:409353 0/3 (0%)
Ig strand F 1287..1292 CDD:409353 0/4 (0%)
Ig 1320..1410 CDD:472250 20/93 (22%)
Ig strand B 1344..1348 CDD:409353 0/3 (0%)
Ig strand C 1357..1361 CDD:409353 2/3 (67%)
Ig strand E 1377..1381 CDD:409353 2/3 (67%)
Ig strand F 1391..1396 CDD:409353 0/6 (0%)
Ig strand G 1404..1407 CDD:409353 0/2 (0%)
TSP1_ADAMTS 1455..1510 CDD:465950 8/55 (15%)
TSP1_ADAMTS 1514..1571 CDD:465950 11/76 (14%)
TSP1_ADAMTS 1628..1682 CDD:465950 11/53 (21%)
PLAC 1686..1716 CDD:462560 4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

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