DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and ADAMTS9

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_891550.1 Gene:ADAMTS9 / 56999 HGNCID:13202 Length:1935 Species:Homo sapiens


Alignment Length:857 Identity:234/857 - (27%)
Similarity:342/857 - (39%) Gaps:229/857 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PGLRQKRQYGANMYLPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDR-GE 92
            ||...|  ||  ..:|:....|..:|:    |..||....||||||||:....|||.|.:.: |.
Human   568 PGKHCK--YG--FCVPKEMDVPVTDGS----WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGG 624

  Fly    93 AVCSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQF--DGVF--YEWVP-YTN--APNPCELN 150
            ..|.|...::.||||:.|.:::.|||.:||:.||.:.|  :|:.  ..||| |:.  ..:.|:|.
Human   625 KYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLF 689

  Fly   151 CMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKT 215
            |...|...||:.|::|:|||.|.....|:||.|.|...|||.:|.|.|:.|||..||||.|:|||
Human   690 CRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKT 754

  Fly   216 IRNTITTKDLAPGYNDLLLLPEGATNIRIEE-----TVPSSNYLACRNHSGHYYLNGDWRIDF-P 274
            :..|..|  :..|||.::.:|.|||||.:.:     .....||||..:..|.:.|||::.:.. .
Human   755 VAGTFNT--VHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAK 817

  Fly   275 RPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEK--NISLDYEYSIP-------- 329
            |.:...|:...|....   .|.:::..:..|.:.|.:.:|...|  |..:.|.::||        
Human   818 REIRIGNAVVEYSGSE---TAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQF 879

  Fly   330 -----------------------------ESLSHSQQ---------------------------- 337
                                         :.|:.|.|                            
Human   880 YWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASR 944

  Fly   338 ----------------------------------------------------DTHTWTHHQFNAC 350
                                                                :|..|.:..:..|
Human   945 SECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTEC 1009

  Fly   351 SASCGGGSQSRKVTCNNRITLAEV-NPSLCDQKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGS 414
            |.||.||:|.|:..|.|  |..:| :.|.|..:.| |..|.|...|| |.|..|:||:|...||.
Human  1010 SKSCDGGTQRRRAICVN--TRNDVLDDSKCTHQEK-VTIQRCSEFPC-PQWKSGDWSECLVTCGK 1070

  Fly   415 DGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGD 479
             |.::|.:.|:    .||..: .|.:|..|  .||.:.|.|.:  ..|..:..|||..|...||.
Human  1071 -GHKHRQVWCQ----FGEDRL-NDRMCDPE--TKPTSMQTCQQ--PECASWQAGPWGQCSVTCGQ 1125

  Fly   480 GKQTRKVTCFIEENGHKRVLPEEDC-VEEKPETEKSCLLTPCE----------------GVDWII 527
            |.|.|.|.|.|  ..:..|:.:.|| ...:|...:.|.|..|.                ...|..
Human  1126 GYQLRAVKCII--GTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRF 1188

  Fly   528 SQWSGCNA-CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCE----AQWFSSEWSK 587
            ..|:.|:| ||:.|..|...|.::.|.|..|..|    .||.||....:|.    .||.:.:||.
Human  1189 GSWTPCSATCGKGTRMRYVSCRDENGSVADESAC----ATLPRPVAKEECSVTPCGQWKALDWSS 1249

  Fly   588 CSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCP------------ 640
            ||..||:|..:|.|:|..:....:    |.|:|:::..||::|||  ....||            
Human  1250 CSVTCGQGRATRQVMCVNYSDHVI----DRSECDQDYIPETDQDC--SMSPCPQRTPDSGLAQHP 1308

  Fly   641 ---------------------GEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSVNCDEEKVEPL 684
                                 .:|.|||||.||..|.||.:.|.|:|......:.|...|:::|.
Human  1309 FQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPD 1373

  Fly   685 SEK-CNSEACTE 695
            .:: |.|..|.:
Human  1374 EQRACESGPCPQ 1385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 22/51 (43%)
ADAMTS_CR_3 116..213 CDD:437068 44/103 (43%)
ADAMTS_spacer1 222..329 CDD:461796 28/114 (25%)
TSP1_ADAMTS 347..396 CDD:465950 18/49 (37%)
TSP1_ADAMTS 400..457 CDD:465950 19/56 (34%)
TSP1_ADAMTS 465..520 CDD:465950 18/55 (33%)
TSP1_ADAMTS 580..632 CDD:465950 17/51 (33%)
TSP1_ADAMTS 643..693 CDD:465950 19/50 (38%)
MSCRAMM_ClfA <1049..1262 CDD:468110
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
ADAMTS9NP_891550.1 Pep_M12B_propep 49..207 CDD:460254
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..242
Cysteine switch. /evidence=ECO:0000250 221..228
ZnMc_ADAMTS_like 293..496 CDD:239801
ADAMTS_CR_2 511..578 CDD:465496 5/13 (38%)
TSP1 591..642 CDD:214559 22/50 (44%)
ADAMTS_CR_3 648..752 CDD:437068 44/103 (43%)
Spacer 753..877 33/128 (26%)
ADAMTS_spacer1 754..871 CDD:461796 30/121 (25%)
TSP1_ADAMTS 885..931 CDD:465950 3/45 (7%)
TSP1_ADAMTS 939..993 CDD:465950 0/53 (0%)
TSP1_ADAMTS 1001..1053 CDD:465950 19/54 (35%)
TSP1_ADAMTS 1056..1108 CDD:465950 19/61 (31%)
TSP1_ADAMTS 1111..1165 CDD:465950 18/55 (33%)
TSP1_ADAMTS 1186..1239 CDD:465950 18/56 (32%)
TSP1_ADAMTS 1242..1295 CDD:465950 19/58 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1289..1330 4/42 (10%)
TSP1_ADAMTS 1332..1383 CDD:465950 19/50 (38%)
TSP1_ADAMTS 1386..1439 CDD:465950 234/857 (27%)
TSP1_ADAMTS 1445..1498 CDD:465950
TSP1_ADAMTS 1501..1554 CDD:465950
TSP1_ADAMTS 1559..1612 CDD:465950
TSP1_ADAMTS 1616..1675 CDD:465950
TSP1_ADAMTS 1681..1729 CDD:465950
GON 1736..1934 CDD:462559
Blue background indicates that the domain is not in the aligned region.

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