DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and ADAMTS9

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_891550.1 Gene:ADAMTS9 / 56999 HGNCID:13202 Length:1935 Species:Homo sapiens


Alignment Length:857 Identity:234/857 - (27%)
Similarity:342/857 - (39%) Gaps:229/857 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PGLRQKRQYGANMYLPESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDR-GE 92
            ||...|  ||  ..:|:....|..:|:    |..||....||||||||:....|||.|.:.: |.
Human   568 PGKHCK--YG--FCVPKEMDVPVTDGS----WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGG 624

  Fly    93 AVCSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQF--DGVF--YEWVP-YTN--APNPCELN 150
            ..|.|...::.||||:.|.:::.|||.:||:.||.:.|  :|:.  ..||| |:.  ..:.|:|.
Human   625 KYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLF 689

  Fly   151 CMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKT 215
            |...|...||:.|::|:|||.|.....|:||.|.|...|||.:|.|.|:.|||..||||.|:|||
Human   690 CRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKT 754

  Fly   216 IRNTITTKDLAPGYNDLLLLPEGATNIRIEE-----TVPSSNYLACRNHSGHYYLNGDWRIDF-P 274
            :..|..|  :..|||.::.:|.|||||.:.:     .....||||..:..|.:.|||::.:.. .
Human   755 VAGTFNT--VHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAK 817

  Fly   275 RPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEK--NISLDYEYSIP-------- 329
            |.:...|:...|....   .|.:::..:..|.:.|.:.:|...|  |..:.|.::||        
Human   818 REIRIGNAVVEYSGSE---TAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQF 879

  Fly   330 -----------------------------ESLSHSQQ---------------------------- 337
                                         :.|:.|.|                            
Human   880 YWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASR 944

  Fly   338 ----------------------------------------------------DTHTWTHHQFNAC 350
                                                                :|..|.:..:..|
Human   945 SECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTEC 1009

  Fly   351 SASCGGGSQSRKVTCNNRITLAEV-NPSLCDQKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGS 414
            |.||.||:|.|:..|.|  |..:| :.|.|..:.| |..|.|...|| |.|..|:||:|...||.
Human  1010 SKSCDGGTQRRRAICVN--TRNDVLDDSKCTHQEK-VTIQRCSEFPC-PQWKSGDWSECLVTCGK 1070

  Fly   415 DGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGD 479
             |.::|.:.|:    .||..: .|.:|..|  .||.:.|.|.:  ..|..:..|||..|...||.
Human  1071 -GHKHRQVWCQ----FGEDRL-NDRMCDPE--TKPTSMQTCQQ--PECASWQAGPWGQCSVTCGQ 1125

  Fly   480 GKQTRKVTCFIEENGHKRVLPEEDC-VEEKPETEKSCLLTPCE----------------GVDWII 527
            |.|.|.|.|.|  ..:..|:.:.|| ...:|...:.|.|..|.                ...|..
Human  1126 GYQLRAVKCII--GTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRF 1188

  Fly   528 SQWSGCNA-CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCE----AQWFSSEWSK 587
            ..|:.|:| ||:.|..|...|.::.|.|..|..|    .||.||....:|.    .||.:.:||.
Human  1189 GSWTPCSATCGKGTRMRYVSCRDENGSVADESAC----ATLPRPVAKEECSVTPCGQWKALDWSS 1249

  Fly   588 CSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCP------------ 640
            ||..||:|..:|.|:|..:....:    |.|:|:::..||::|||  ....||            
Human  1250 CSVTCGQGRATRQVMCVNYSDHVI----DRSECDQDYIPETDQDC--SMSPCPQRTPDSGLAQHP 1308

  Fly   641 ---------------------GEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSVNCDEEKVEPL 684
                                 .:|.|||||.||..|.||.:.|.|:|......:.|...|:::|.
Human  1309 FQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPD 1373

  Fly   685 SEK-CNSEACTE 695
            .:: |.|..|.:
Human  1374 EQRACESGPCPQ 1385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 22/51 (43%)
ADAM_spacer1 214..329 CDD:283607 31/122 (25%)
TSP1 468..521 CDD:214559 18/53 (34%)
TSP_1 645..693 CDD:278517 18/48 (38%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
ADAMTS9NP_891550.1 Pep_M12B_propep 73..206 CDD:279848
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..242
Cysteine switch. /evidence=ECO:0000250 221..228
Reprolysin 293..499 CDD:279729
ZnMc_ADAMTS_like 293..496 CDD:239801
TSP1 591..642 CDD:214559 22/50 (44%)
Spacer 753..877 33/128 (26%)
ADAM_spacer1 753..871 CDD:283607 31/122 (25%)
TSP1 1001..1054 CDD:214559 21/56 (38%)
TSP1 1059..1103 CDD:214559 17/51 (33%)
TSP1 1114..1166 CDD:214559 18/53 (34%)
TSP1 1186..1239 CDD:214559 18/56 (32%)
TSP1 1239..1296 CDD:214559 20/62 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1289..1330 4/42 (10%)
TSP1 1332..1384 CDD:214559 19/51 (37%)
TSP1 1386..1440 CDD:214559 234/857 (27%)
TSP1 1445..1499 CDD:214559
TSP1 1504..1555 CDD:214559
TSP1 1562..1613 CDD:214559
TSP1 1615..1676 CDD:214559
GON 1738..1934 CDD:285848
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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