DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and adamts6

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_017213499.1	Gene:	adamts6 / 569099	ZFINID:	ZDB-GENE-091113-9	Length:	1116	Species:	Danio rerio

Alignment Length:	615	Identity:	207/615 - (33%)
Similarity:	296/615 - (48%)	Gaps:	99/615 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WTPWSSPSDCSRTCGGGVSYQTREC-LRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCS 123
            |.||:...:||||||||||...|.| ......|...|.|..:||.||||..|||...|||.:||:
Zfish   560 WGPWTVWGECSRTCGGGVSSSMRHCDSPAPSGGGKYCLGERKRYRSCNTDACPEGSRDFREKQCA 624

  Fly   124 RFDRQQFDGVFYEWVPYT-NAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMP 187
            .||...|.|.:|.|.||| ....||.|||:.:|..||..:...|:|||||....||:|:||||..
Zfish   625 DFDSLPFRGKYYNWKPYTGGGVKPCALNCLAEGYNFYTERSPAVIDGTRCQGDSLDICINGECKH 689

  Fly   188 VGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSN 252
            ||||.:||||||||:||.||||||||:.............||.:::.:|:|:.:|.|.|...|.|
Zfish   690 VGCDNILGSDAKEDRCRVCGGDGSTCELTEGLFNDSLPRGGYMEVVQIPKGSVHIEIREVAVSKN 754

  Fly   253 YLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQE 317
            |:|.::....||:||.|.||:||....|.:.::|:|..   ..|:.|...|...|:|.:::|:||
Zfish   755 YIALKSEGDDYYINGAWTIDWPRKFDIAGTAFHYKRPT---DEPESLEALGATMENLVVMVLLQE 816

  Fly   318 KNISLDYEYSIP--ESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCD 380
            :|:.:.|::::|  .:.|...:...:|.|..::.|||:|.||||.::|.|......:.|..|.||
Zfish   817 QNLGIQYKFNVPIQRTGSGDNEVGFSWHHLPWSECSATCAGGSQKQEVVCKRLDDNSVVQNSYCD 881

  Fly   381 QKSKPV-EEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKE 444
            |.|||. .::.|.||||.|.|..|:||:|.|.| ..|.:.|::.|.|..:..|....||:.||.
Zfish   882 QDSKPPGNQRRCNTEPCPPEWFIGDWSECGKTC-DGGIRTRTVLCIRKINPAEEETLEDSHCLT- 944

  Fly   445 VGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKP 509
              ::|..::.||.  ::||                                             |
Zfish   945 --HRPIEQESCNN--QSCP---------------------------------------------P 960

  Fly   510 ETEKSCLLTPCEGVDWIISQWSGCN-ACGQNTETRTAICGNKE-GKVYPEEFC-EPEVPTLSRPC 571
            :              |:...||.|. .||...:.|..:|.:.: .|.:|...| :...|.:...|
Zfish   961 Q--------------WVTLDWSECTPKCGPGFKHRIVLCKSSDLTKTFPAALCSDHSKPPVRIRC 1011

  Fly   572 KSPKC-EAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGE 635
            ...:| ..:|...||.:|||.||.|.:.|.|.|..:.|:      ..|:|....:|.:.|.||
Zfish  1012 SLGRCPPPRWIPGEWGQCSAQCGLGQQMRTVQCLSYTGQ------PSSECLDSLRPNTMQQCE-- 1068

  Fly   636 EKVCPGEWFTGPWGKC-SKPCGGGERVREV 664
                         .|| |.|..||:..::|
Zfish  1069 -------------SKCDSTPISGGDECKDV 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	24/51 (47%)
		ADAM_spacer1	214..329	CDD:283607	33/114 (29%)
		TSP1	468..521	CDD:214559	1/52 (2%)
		TSP_1	645..693	CDD:278517	7/21 (33%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
adamts6	XP_017213499.1	Pep_M12B_propep	40..187	CDD:307618
		ZnMc_ADAMTS_like	249..464	CDD:239801
		TSP1	560..612	CDD:214559	24/51 (47%)
		ADAM_spacer1	719..828	CDD:310520	33/111 (30%)
		TSP1	847..899	CDD:214559	22/51 (43%)
		TSP1	901..959	CDD:214559	19/63 (30%)
		TSP1	1021..1068	CDD:214559	17/52 (33%)
		PLAC	1082..1114	CDD:312271	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4872
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2734
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940