DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and si:ch211-267e7.3

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_696251.5	Gene:	si:ch211-267e7.3 / 567853	ZFINID:	ZDB-GENE-070912-265	Length:	963	Species:	Danio rerio

Alignment Length:	936	Identity:	233/936 - (24%)
Similarity:	341/936 - (36%)	Gaps:	304/936 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SVTPGGEGND-----PDE----WTPWSSPSDCSRTCGGGVSYQTRECLRR-----DDRGEAVCSG 97
            :|....||.:     |||    |..|||.|.|||||||||..|.|.||::     .:...:.|.|
Zfish    31 NVKDSSEGREDLQRHPDEVAQWWGEWSSWSTCSRTCGGGVRSQERHCLQQRLTSTQNINSSFCIG 95

  Fly    98 GSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVP-----YTNAPN-PCELNC-MPKG 155
            .|::|..|..|.||.....|:..|||:|:.:.|....|||||     |.|..| ||:|.| ...|
Zfish    96 PSKQYQLCTNQPCPNSRISFKQHQCSQFNAKAFSRKHYEWVPLYPDDYINISNKPCDLQCTTTTG 160

  Fly   156 ERFYYRQREKVV---DGTRCNDKDLD-VCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTI 216
            |      |:.:|   |||.|.|.... ||:.|:|..||||..|.|....|||..|||:|::|..:
Zfish   161 E------RQLLVPAHDGTFCRDGIYQGVCIEGQCQVVGCDGKLYSSKTIDKCGVCGGNGASCYRV 219

  Fly   217 RNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFAN 281
            ..|........||..:..:|.|||:|:|.|...:.|.||..:.:||::.||:..||.|:....|.
Zfish   220 SGTYRKGITQLGYVFITNIPVGATDIQIIERRKTENILALSDEAGHFFFNGNSVIDNPQNFHVAG 284

  Fly   282 SWWNYQRKPM-----GFAAPDQLTCSGPISESLFIVML-VQEKNISLDYEYSIP----------- 329
            :.:.| |:|.     ||   :.:...||..::|.::.. :..|...:.|||::|
Zfish   285 TVFKY-RRPANLFSDGF---EYIMAQGPTQQALNVMYYNLNGKMPHITYEYTVPRAPAFPMTSTP 345

  Fly   330 ----------------------------------------------------------------- 329

Zfish   346 EQPQISNLMSKTSRDSSVAEPKGNTSSTEHNEIGARKQHEKKSNQSSSLVPQDNVDVHEELLWGL 410

  Fly   330 ----------------------------------------------------------------- 329

Zfish   411 QASVNFSELPALVLFRPASEVLQNELDDEIHHLEAQENFGPDSNLIDGDSSSSSDSNTSIPLLKS 475

  Fly   330 ----------------------------------------------------------------- 329

Zfish   476 LLYDGASWSSRQPCKDSSALSGCSILKLNSSAPLDNSLTLEIYPGSLDLHSPDGEPRTNDSTNHQ 540

  Fly   330 ------------------------ESLSH--SQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNR 368
                                    |||.|  |..|.:.|....:..||::|..|..:....| .:
Zfish   541 SNILQLHQMEPVQAPHSESNEFEVESLDHDVSMSDMYRWKVSAYAPCSSTCTTGISTSYALC-VK 604

  Fly   369 ITLAEVNPSLCDQKSKP-VEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGE 432
            ....||:.|.||..::| ...:.|..:.|.|.|....||:||:.|| :|||.|::.|.::.:.|.
Zfish   605 YDGTEVDESYCDALTRPEPTHEFCTGKECLPRWETSRWSECSRTCG-EGFQFRTVRCWKMMAPGF 668

  Fly   433 HTVEEDAVCLKEVGNKPATKQECNRDVKNC-PKYHLGPWTPCDKLCGD-GKQTRKVTCFIEENGH 495
            .:...|.:|......||.|::.|..  |:| |::.:..|:.|...||. |.::|.|.|.:|
Zfish   669 DSSVYDELCQAVELQKPMTRKACKS--KSCGPQWEISDWSECSARCGGRGVRSRDVRCSME---- 727

  Fly   496 KRVLPEEDCVEEKPETEKSCLLTPCEGVDWIISQWSGCNA-CGQNTETRTAICGNKEGKVYPEEF 559
            .|:..|    ..||.:::.|...||:. .|.:|.|..|:. ||:....|..:|.|..|||..:..
Zfish   728 ARLCNE----STKPVSQRECEGPPCDR-RWTVSDWGPCSGPCGEGRMKRYVVCKNSNGKVISDGQ 787

  Fly   560 CEPEV-PTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKE 623
            |:||: |....||....|.|.|...||.:|::.||:|||:|.|:|...:. .|.....:..|::.
Zfish   788 CDPELKPLAVHPCGDKNCPAHWVEQEWEQCNSTCGRGVKTRQVVCAGLEA-GVFKEFPERMCDRA 851

  Fly   624 TKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSVNCDEEKVEPLSEKC 688
            .:|.....|  .|:.| .:|||..|.:|||.||.|.|||||.|........:||........:.|
Zfish   852 LRPADTAAC--FERPC-SKWFTTSWSQCSKTCGIGVRVREVKCYQGEELGHSCDTTLRPEARQSC 913

  Fly   689 NSEACTEDEILPLTSTDKPIEDDEED 714
            ..:.||         |:.|.:|..:|
Zfish   914 EVQPCT---------TEPPADDACQD 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	24/55 (44%)
		ADAM_spacer1	214..329	CDD:283607	33/120 (28%)
		TSP1	468..521	CDD:214559	15/53 (28%)
		TSP_1	645..693	CDD:278517	17/47 (36%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
si:ch211-267e7.3	XP_696251.5	TSP1	53..109	CDD:214559	24/55 (44%)
		ADAM_spacer1	217..334	CDD:283607	33/120 (28%)
		TSP1	637..>660	CDD:214559	11/23 (48%)
		TSP1	700..749	CDD:214559	15/56 (27%)
		TSP1	752..806	CDD:214559	18/53 (34%)
		TSP1	865..918	CDD:214559	20/53 (38%)
		PLAC	928..959	CDD:285849	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810