Protein Alignment Ppn and Ppn

DIOPT Version :10

• Sequence 1: NP_788752.2
• Gene: Ppn / 43872
• FlyBaseID: FBgn0003137
• Length: 2898
• Species: Drosophila melanogaster
• Sequence 2: XP_061503172.1
• Gene: Ppn / 5667695
• VectorBaseID: AGAMI1_011200
• Length: 2587
• Species: Anopheles gambiae
• Alignment Length: 2974
• Identity: 1307/2974 - (43%)
• Similarity: 1722/2974 - (57%)
• Gaps: 492/2974 - (16%)

  Fly    10 TALVAFIVLASIHDSQSRFPGLRQKRQYGANMYLPESSVTP-GGEGNDPDEWTPWSSPSDCSRTC 73
            |.|:..:|...:..::||..|.|.|||:|:|:|.|||.:.| ||||...:.|:.|.:||:|||||
Mosquito     4 TKLLVLLVTLQLSFTESRRFGARHKRQHGSNLYQPESFIIPGGGEGPPHERWSAWGAPSECSRTC 68

  Fly    74 GGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWV 138
            ||||:||.||||..|..|..||:||.|:|||||||||||.|.|||.||||.|:...|:|..|:||
Mosquito    69 GGGVAYQERECLDLDHTGAPVCTGGKRKYFSCNTQDCPERELDFRKQQCSEFNDVPFEGHRYQWV 133

  Fly   139 PYTNAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECMPVGCDMMLGSDAKEDKC 203
            |||.|||||||||||.|||||||.|.||.|||||||:..||||:|.|..|||||||||.||||||
Mosquito   134 PYTRAPNPCELNCMPVGERFYYRHRAKVADGTRCNDESFDVCVDGTCQSVGCDMMLGSQAKEDKC 198

  Fly   204 RKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGD 268
            |.|.||||:|||....:...:|..|||||||:|.||||:.|.|..||:||||.||.:|.|:|||:
Mosquito   199 RICRGDGSSCKTASGLLDASNLQVGYNDLLLIPAGATNVLISERAPSNNYLAIRNLTGFYHLNGN 263

  Fly   269 WRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSI-PESL 332
            :||||||.:.||.|.|:|:|:|.||||||:|||.||.:||:::|:|.|::|:.::||||: .:|.
Mosquito   264 YRIDFPRTIHFAGSDWHYERRPQGFAAPDRLTCLGPTTESVYLVLLSQDRNVGVNYEYSVSSKSA 328

  Fly   333 SHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKPVEEQACGTEPCA 397
            ...:.|:::|.:..|..|:.:||||.|:|.||||::.:|.||:..||:...||...|.||.:.|.
Mosquito   329 PVDEPDSYSWMYTAFEPCTVTCGGGVQTRNVTCNSKSSLKEVDEGLCNLGEKPPTTQKCGQQSCP 393

  Fly   398 PHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNC 462
            |.|.||.||.|||.||::|.|.|.:.|||:|:.||....||.|||::|||||||::|||:.: .|
Mosquito   394 PRWFEGPWSNCSKPCGTEGKQTREVYCERVSADGETKKIEDDVCLEQVGNKPATERECNQGI-IC 457

  Fly   463 PKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEGVDWII 527
            |::::|.|:||:||||:|::||||.|:.:|||...||.:|:|:.|||...:.|:|.||||||::.
Mosquito   458 PEWYVGRWSPCNKLCGEGERTRKVVCYRKENGRITVLEDEECITEKPAVSEQCMLRPCEGVDYVT 522

  Fly   528 SQWSGCNACGQNTETRTAICGNKEGKVYPEEFC-EPEVPTLSRPCKSPKCEAQWFSSEWSKCSAP 591
            |.||||:.||...||||..|.:|.|.||...|| :.::|.|.|.||...||.||::|:||||||.
Mosquito   523 SSWSGCDECGATVETRTVHCASKSGTVYDASFCADRQLPELRRECKLTPCEYQWYTSQWSKCSAV 587

  Fly   592 CGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCG 656
            |||||::|.|:||.|||:::..||||.||:.|.|||.||:|||..: |||:||.|||..|.|.||
Mosquito   588 CGKGVQTRTVVCGVFDGQSLKRADDDYKCDPEQKPEKEQECEGPPE-CPGQWFAGPWTDCDKGCG 651

  Fly   657 GGERVREVLCLSNGT--KSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDK------------- 706
            ||...|:||||:|||  ...|||.:|::..:|.||...|||||::|:....|
Mosquito   652 GGVMSRKVLCLANGTVVPETNCDVDKIQLATESCNKHDCTEDEVIPVEVGSKQPEVEDDYDEDEL 716

  Fly   707 -PIEDDEEDC--------DEDGIELIS----DG---LSDDEKSEDVIDLEGTAK--TETTPEAED 753
             ..||||||.        :|||....|    ||   :::|....:.|:|:.:..  ||::.|.::
Mosquito   717 CEEEDDEEDASGDASGDGEEDGSGAASTEGQDGVMMVTEDTSLAEGIELDSSVSGTTESSLETDE 781

  Fly   754 LMQSDSPTPYDEFESTGTTFEGSGYDSESTTDSGISTEGSGDDEETSEASTDLSSSTDSGSTSSD 818
            :|.||: |.:|    ||.|....|..:|:|      .|||||      .|:.:|..::......:
Mosquito   782 MMMSDA-TGFD----TGATDPDEGSTTEAT------VEGSGD------GSSPMSEVSEGSGDEGE 829

  Fly   819 STSSDSSSSISSDATSEAPASSVSDSSDSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASD 883
            :|:..::|..|.||:|:|                           ..|:||||||..:  |.||:
Mosquito   830 ATTVVATSRASDDASSDA---------------------------AGSTTEASASSGS--SMASE 865

  Fly   884 STGSTNASDSTPESSTEASSSTDDSTDSSDNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTT 948
            |:|||.|             |.:.||:|||.:|....||.|.|..:.:||         |||:|
Mosquito   866 SSGSTEA-------------SAESSTESSDMASTSQASSVEDSMPTTTDS---------GVSTT- 907

  Fly   949 ENSSDSTSDATSDSTASSDSTDSTSDQTTETTPESSTDSTESSTLDASSTTDASSTSESSSESST 1013
             ::||||:|.|..||:|:|. :||:|.::.||   .||.|  ||:|.:||||..||::||..:|:
Mosquito   908 -DASDSTTDVTETSTSSTDE-ESTTDLSSTTT---MTDLT--STMDDASTTDVPSTTDSSEAASS 965

  Fly  1014 DGSSTTSNSASSETTGLSSDGSTTDATTAASDNTDITTDGSTDESTDGSSNASTEGSTEGASEDT 1078
            ..:|.|:.|:|      |||||||:.              |:|||:..||....||     ||.|
Mosquito   966 TVASDTATSSS------SSDGSTTEV--------------SSDESSTDSSTKMVEG-----SEST 1005

  Fly  1079 TISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSSDVTSDSTITDSSPSTEVSGSTDSSSSTD 1143
            ..|..||.|..|....:.|.|:..|:|.|                                 |..
Mosquito  1006 ETSVMSSSSEPSVTGTSMDSSSESGATEE---------------------------------SAT 1037

  Fly  1144 GSSTDASSTEASSTDVTESTDSTVSG-GTSDTTESGPTEESTTEGSTESTTEGSTDSTQSTDLDS 1207
            |:|||.|||      ..:||:.||:| .|.|.|.|..|||:..| :|....:.|||::
Mosquito  1038 GASTDGSST------TVDSTEPTVTGASTEDFTGSTVTEETVGE-TTFEIWDSSTDAS------- 1088

  Fly  1208 TTSDIWSTSDKDDESESSTPYSFDSEVTK-SKPRKCK--PKKSTCAKSEYGCCPDGKSTPKGPFD 1269
                  :|.|:.|:|||||||:..|.:.| .||||||  ||...||||.:|||||||:...|||.
Mosquito  1089 ------TTDDEADDSESSTPYTLTSIIAKEQKPRKCKPRPKVPQCAKSTHGCCPDGKTKASGPFL 1147

  Fly  1270 EGCPIAKTCADTKYGCCLDGVSPAKGKNNKGCPKSQCAETLFGCCPDKFTAADGENDEGCP-ETT 1333
            |||.:|:||.:||:|||.||||||||.|.|||||::||:|||||||||.|.|:|.:.|||| |||
Mosquito  1148 EGCTLAETCKETKHGCCPDGVSPAKGPNGKGCPKAECADTLFGCCPDKVTPAEGNDAEGCPVETT 1212

  Fly  1334 TVPPTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGC----- 1393
            |:||                               .|:.::.|||||..|.||||..:||
Mosquito  1213 TMPP-------------------------------GCTAAKHGCCPDGTTEAKGPKAKGCPGVEK 1246

  Fly  1394 -------GLASP-------VAKGCAESENGCCPDGQTPASGPNGEGCSGCTRERFGCCPDSQTPA 1444
                   |...|       ..:|||.:.:|||||..|.||||:|:||..|:||.||||||.:|||
Mosquito  1247 EEEEAPAGTEQPTPEELPTAVEGCATTPHGCCPDNATAASGPDGQGCEPCSREPFGCCPDGKTPA 1311

  Fly  1445 HGPNKEGCCLDTQFGCCPDNILAARGPNNEGCECHYTPYGCCPDNKSAATGYNQEGCACETTQYG 1509
            ||.:.|||||.|.:||||||::||||||.|||:|.|.||||||||:::|.|::.|||.|:..|:|
Mosquito  1312 HGHSGEGCCLQTPYGCCPDNVVAARGPNLEGCDCQYAPYGCCPDNRTSARGHDNEGCGCQYAQHG 1376

  Fly  1510 CCPDKITAAKGPKHEGCPCETTQFGCCPDGLTFAKGPHHHGCHCTQTEFKCCDDEKTPAKGPNGD 1574
            |||||.|.|.||..|||||...||||||||:|.|||||:.|||||.:|||||.|.|||||||:|:
Mosquito  1377 CCPDKETEATGPSFEGCPCHAHQFGCCPDGVTAAKGPHNQGCHCTHSEFKCCGDGKTPAKGPDGE 1441

  Fly  1575 GCTCVESKFGCCPDGVTKATDEKFGGCENVQEPPQKACGLPKETGTCNNYSVKYYFDTSYGGCAR 1639
            ||||.:||:|||||||::|...||.||..|.|.|||||.|||:.|.|:||:||::||..||||.|
Mosquito  1442 GCTCADSKYGCCPDGVSEAQGSKFEGCTAVPESPQKACALPKDKGPCHNYTVKHFFDVEYGGCGR 1506

  Fly  1640 FWYGGCDGNDNRFESEAECKDTCQDYTGKHVCLLPKSAGPCTGFTKKWYFDVDRNRCEEFQYGGC 1704
            ||||||:||:|||:|..|||:.|:..|||.||.|||.:|||||....||:|.:||.|.:|.||||
Mosquito  1507 FWYGGCEGNNNRFDSAEECKNICETPTGKDVCHLPKISGPCTGHYNMWYYDAERNMCAQFTYGGC 1571

  Fly  1705 YGTNNRFDSLEQCQGTCAASENLPTCEQPVESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNN 1769
            .|..|||:|.|:|:..|:..::.|.||||:|:|||.|.|||||||.|||.|.||.:|||||||||
Mosquito  1572 LGNANRFESQEECKALCSVDDSKPPCEQPMEAGPCNGTFERWYYDKETDACHPFYFGGCKGNKNN 1636

  Fly  1770 YPTEHACNYNCRQPGVLKDRCALPKQTGDC-------SEKLAKWHFSESEKRCVPFYYSGCGGNK 1827
            ||||.:|.|:|::|||.|..|:.|..||.|       .::.|:|:|:...::|:|||::|||||.
Mosquito  1637 YPTEASCGYHCKKPGVHKPSCSEPLDTGSCEAQQQQQQQQQARWYFASDSQKCMPFYFTGCGGND 1701

  Fly  1828 NNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGNENRFPTE 1892
            |.|.:.:.||:.||.:|.||||.:|||:|||.||...||:||:|:.||||||||||||.|.|..|
Mosquito  1702 NQFVSRDHCEEQCPPKVEKDICFLPAEIGECQNYTAHWYFDTKDERCRQFYYGGCGGNGNNFADE 1766

  Fly  1893 ESCLARC-DRKPEPTTTTPATRPQPSRQDVCDEEP-APGECSTWVLKWHFDRKIGACRQFYYGNC 1955
            :||:.|| :..|:|....|...|      |....| ||||        .|||
Mosquito  1767 QSCINRCIEEGPKPAPAPPGAAP------VAPVRPAAPGE--------PFDR------------- 1804

  Fly  1956 GGNGNRFETENDCQQRCLSQEPPAPTPPRAPAPTRQPDPAPTVAQCSQPADPG--QCDKWALHWN 2018
                                                       :||..|.|.|  :|..:...:.
Mosquito  1805 -------------------------------------------SQCQLPMDNGDRECSPYEARYY 1826

  Fly  2019 YNETEGRCQSFYYGGCGGNDNRFATEEECSARCSVNIDIRIGADPVEHDTSKCFLAFEPGNCYNN 2083
            ::...|.|:.|.|.|||||.|.|..:|||...|        |::. :.:...|.|....|.|..|
Mosquito  1827 FSTQTGTCELFTYTGCGGNGNNFQRKEECERSC--------GSEG-QGEQDVCQLPHAYGECSGN 1882

  Fly  2084 VTRWFYNSAEGLCDEFVYTGCGGNANNYATEEECQNECNDAQTTCALPPVRGRCS-DLSRRWYFD 2147
            ..||||...|..|..|.|:|||||.||:|:|.||:..|          |..||.. |:..|
Mosquito  1883 EERWFYEPHEQRCVRFAYSGCGGNGNNFASEAECERSC----------PAGGRAPVDVDVR---- 1933

  Fly  2148 ERSGECHEFEFTGCRGNRNNFVSQSDCLNFCIGEPVVEPSAPTYSVCAEPPEAGECDNRTTAWFY 2212
                                            |....:|:|...|.|.|.|:.|:.|.....::|
Mosquito  1934 --------------------------------GPHEQQPAAGNGSRCEEVPDYGDGDGDEILFYY 1966

  Fly  2213 DSENMACTAFTYTGCGGNGNRFETRDQCERQCGEFKGVDVCNEPVTTGPCTDWQTKYYFNTASQA 2277
            ::|..:|..|.|:|.|||.||:.:.::|||.||.::|||||.:.|..|.||:....||:::.:.|
Mosquito  1967 NAERQSCERFRYSGAGGNANRYRSEEECERVCGMYRGVDVCQDAVQAGQCTESIPMYYYDSRTHA 2031

  Fly  2278 CEPFTYGGCDGTGNRFSDLFECQTVCLAGREPRVGSAKEICLLPVATGRCNGPSVHERRWYYDDE 2342
            |..|.|.||:|.||||:...||:..|                            ||:|..:  |:
Mosquito  2032 CYAFNYSGCEGNGNRFASAEECEGTC----------------------------VHQRPGF--DD 2066

  Fly  2343 AGNCVSFIYAGCSGNQNNFRSFEACTNQCRPEPNKQDNEIGQNPCDTFDAECQELRCPYGVRRVA 2407
            |.|.|                                     |||:.:|.||.:|.||||   :|
Mosquito  2067 AANAV-------------------------------------NPCEQYDHECSQLHCPYG---IA 2091

  Fly  2408 ARSQPE--CTQCICENPCEGYSCPEGQQCAIDVAS-----SDDRQFAPVCRDIYKPGECPALSAN 2465
            ....|.  |.:|.|.:||.||.||.|.:|.:||.|     ....:|..|||:..|||:||.| ||
Mosquito  2092 KSYDPANGCERCQCNDPCAGYFCPAGSECVVDVQSGGAFVGTGSEFVGVCRESQKPGDCPVL-AN 2155

  Fly  2466 ASGCARECYTDADCRGDNKCCSDGCGQLCVHPA------RPT--QPPRTQAPVVSYPGDARAALE 2522
            |:.|:|:|.|||||||:||||..||..:|:.|.      |||  ||        ..||.  ..||
Mosquito  2156 ATHCSRDCNTDADCRGNNKCCQAGCALICISPVDRASVDRPTGGQP--------GVPGP--TVLE 2210

  Fly  2523 PKEAHELDVQTAIGGIAVLRCFATGNPAPNITWSLKNLVINTNKGRYVLTANGDLTIVQVRQTDD 2587
            .....|||:::..||||:|||||||.|.|:|.|....:::|||:||||:|::|||.|||:.:||.
Mosquito  2211 EVPQEELDIKSEEGGIALLRCFATGFPPPSIRWRKGEIMLNTNQGRYVITSDGDLQIVQLHRTDS 2275

  Fly  2588 GTYVCVASNGLGEPVRREVALQVTEPVSQPAYIYGDKNVTQIVELNRPAVIRCPAGGFPEPHVSW 2652
            |||||:|.||:|||..|||.|.|.:||.:.|||.|:.|.:.:|||..||.:||||||:|:|.|:|
Mosquito  2276 GTYVCIADNGIGEPALREVQLTVNDPVPRDAYIAGNLNDSLVVELESPATLRCPAGGYPKPIVTW 2340

  Fly  2653 WRNGQMFGLKNNLMARDYSLVFNSIQLSDLGLYTCEVYN-QRRPVSLRVTLKAVGPVRPLSPEEE 2716
            ||:..|..||  ::.|||||....::|.|||.|.|:.|: ..:.:|..||:........::|::|
Mosquito  2341 WRDTFMMPLK--MVNRDYSLSLPRVRLEDLGPYVCQAYSGAGKGISRTVTVYGYNLPAQINPQDE 2403

  Fly  2717 QYMQYVL-NPA-TRPVTQRPSYPYRPTRPAYVPEPTV-----NVHAVLALEPKNSYTPGSTIVMS 2774
            :|::||: .|| .||......||.||..|...|.|.|     .|...:.........|.|...::
Mosquito  2404 RYVKYVVAAPAPARPAPPVDRYPSRPRPPVAQPPPVVVRPPAPVSVQMHFPQGRDLRPNSNFTIN 2468

  Fly  2775 CSVQGYPEPNVTWIKDDVPLYNNERVQITYQPHRLVLSDVTSADSGKYTCRASNAYTYANGEANV 2839
            |:|.|||.|.|.|.||...|...:|:.|| ..|:|::.....:|:|:|.|.|.|..:.|..|.::
Mosquito  2469 CTVDGYPRPTVNWFKDGQMLVPTDRIHIT-DAHQLMVFGAIPSDTGRYKCLARNEMSEAFQENSI 2532

  Fly  2840 SIQSVVPVSPECVDNPYFANCKLIVKGRYCSNPYYTQFCCRSCTLAGQV 2888
            .::.|. |.|.|.||...|.|.|||.|.||::.||.:|||||||||||:
Mosquito  2533 HVEGVY-VPPGCTDNQLLAKCDLIVAGHYCNHKYYARFCCRSCTLAGQI 2580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	34/50 (68%)
		ADAMTS_CR_3	116..213	CDD:437068	71/96 (74%)
		ADAMTS_spacer1	222..329	CDD:461796	62/107 (58%)
		TSP1_ADAMTS	347..396	CDD:465950	22/48 (46%)
		TSP1_ADAMTS	400..457	CDD:465950	33/56 (59%)
		TSP1_ADAMTS	465..520	CDD:465950	26/54 (48%)
		TSP1_ADAMTS	580..632	CDD:465950	32/51 (63%)
		TSP1_ADAMTS	643..693	CDD:465950	26/51 (51%)
		MSCRAMM_ClfA	<1049..1262	CDD:468110	76/216 (35%)
		Kunitz_papilin_lacunin-like	1612..1663	CDD:438681	32/50 (64%)
		Kunitz_BPTI	1670..1721	CDD:425421	28/50 (56%)
		Kunitz-type	1730..1780	CDD:438633	37/49 (76%)
		Kunitz_BPTI	1789..1840	CDD:425421	21/57 (37%)
		Kunitz_papilin_mig6-like	1849..1899	CDD:438679	31/49 (63%)
		Kunitz_papilin_mig6-like	1922..1972	CDD:438679	8/50 (16%)
		Kunitz_papilin_mig6-like	2001..2051	CDD:438679	19/51 (37%)
		Kunitz-type	2071..2121	CDD:438633	24/49 (49%)
		Kunitz_BPTI	2127..2178	CDD:425421	5/51 (10%)
		Kunitz_BPTI	2193..2245	CDD:425421	19/51 (37%)
		Kunitz_BPTI	2252..2303	CDD:425421	21/50 (42%)
		Kunitz_BPTI	2317..2372	CDD:425421	7/54 (13%)
		WAP	2455..2497	CDD:459672	26/41 (63%)
		Ig	2530..2610	CDD:472250	47/79 (59%)
		Ig strand B	2539..2543	CDD:409353	2/3 (67%)
		Ig strand C	2552..2556	CDD:409353	1/3 (33%)
		Ig strand E	2576..2579	CDD:409353	2/2 (100%)
		Ig strand F	2589..2594	CDD:409353	4/4 (100%)
		Ig strand G	2603..2606	CDD:409353	1/2 (50%)
		IG_like	2627..2703	CDD:214653	35/76 (46%)
		Ig strand B	2636..2640	CDD:409353	1/3 (33%)
		Ig strand C	2649..2653	CDD:409353	1/3 (33%)
		Ig strand E	2670..2674	CDD:409353	3/3 (100%)
		Ig strand F	2684..2689	CDD:409353	2/4 (50%)
		Ig strand G	2697..2700	CDD:409353	1/2 (50%)
		I-set	2766..2845	CDD:400151	26/78 (33%)
		Ig strand B	2771..2775	CDD:409353	0/3 (0%)
		Ig strand C	2784..2788	CDD:409353	1/3 (33%)
		Ig strand F	2821..2826	CDD:409353	2/4 (50%)
		PLAC	2851..2883	CDD:462560	18/31 (58%)
Ppn	XP_061503172.1	None