DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and wfikkn2a

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_693394.5 Gene:wfikkn2a / 564992 ZFINID:ZDB-GENE-120914-1 Length:573 Species:Danio rerio


Alignment Length:515 Identity:123/515 - (23%)
Similarity:168/515 - (32%) Gaps:163/515 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1406 SENGCCPDGQTPASGPNGEGCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAAR- 1469
            |..|.||:...|....  :..|.|.||   |..|......    |.||.:.   |...:.:||| 
Zfish    40 SHAGMCPNEMNPNLWV--DAMSTCARE---CESDQDCEPF----EKCCSNV---CGLKSCVAARY 92

  Fly  1470 -------GPNN--EGCECHYTPYGCCPDNKSAATGYNQEGCACE--TTQYGC-CPDKITAAKGPK 1522
                   ||..  :|..|          :|...|   |:|..||  ..|..| |.|:        
Zfish    93 MDIQGRKGPMGMPKGVTC----------DKFMCT---QQGSECEIWDGQPVCKCKDR-------- 136

  Fly  1523 HEGCPCETTQFGCCPDGLTFAKGPHHHGCH-----CTQ----TEFKC-----------CDDEKT- 1566
               |..|.. |.|..||:|:     ::.|:     ||:    ||..|           ...|.| 
Zfish   137 ---CGREPF-FTCASDGMTY-----YNKCYMDAEACTRGITLTEVTCRYHFSLSNTSPLPVETTA 192

  Fly  1567 ------PAKGPNGDGCTCVESK-------------FGCCPDGVTKAT---DEKFGGCENVQEPPQ 1609
                  |...|.......:.||             |.|...|..|..   :::..|.||....|.
Zfish   193 RPTTAHPITTPMDIQRPAMLSKPAHHFVFVGETASFLCEVTGKPKPAITWEKQIEGKENTVMRPN 257

  Fly  1610 KACG--LPKETGTCNNYSVKYYFDTSYGGCARFWYGGCDG-------------------NDNRFE 1653
            ...|  :....|....|:.:.. |.....|.....||...                   |..|..
Zfish   258 HMQGNIVVTNIGQLVIYNAQVQ-DAGIYTCTATNQGGSVQAHFPLSVVPREQLKPVLVMNSTRLP 321

  Fly  1654 SEAECKDTCQDYTGKHVCLLPKSAGPCTGFTKKWYFDVDRNRCEEFQYGGCYGTNNRFDSLEQCQ 1718
            :|.              ||.......|...:.:||::..||.|..|.|..|....|.||:.:.|.
Zfish   322 AEE--------------CLKAPDMDDCGEESMRWYYEAKRNNCFTFTYSQCNKNRNHFDAYDSCM 372

  Fly  1719 GTCAASENLPTCEQPVESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPTEHACNYNCRQP 1783
            .:|.|....| |..|...|||.....||.|.:....|:.|.||||.||:||:.::.||       
Zfish   373 LSCGAELAAP-CSLPSVQGPCKAYKPRWAYSHALKKCQSFVYGGCGGNENNFESKEAC------- 429

  Fly  1784 GVLKDRCALPKQTGDCSEKLAKWHFSESEKRCVPFYYSGCGGNKNNFPTL----ESCEDH 1839
               ::.|..|| |.:|.:       .:..::.||   |.|   |::|..|    |..|||
Zfish   430 ---EEMCPFPK-THNCKQ-------CKPRQKMVP---SFC---KSDFVVLGRISELTEDH 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443 10/72 (14%)
Kunitz_BPTI 1670..1721 CDD:278443 15/50 (30%)
Kunitz_BPTI 1729..1781 CDD:278443 20/51 (39%)
Kunitz_BPTI 1789..1840 CDD:278443 16/55 (29%)
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
wfikkn2aXP_693394.5 WAP 43..89 CDD:278522 14/57 (25%)
KAZAL_FS 137..173 CDD:238052 12/41 (29%)
I-set 209..303 CDD:254352 17/94 (18%)
Ig 223..303 CDD:299845 15/80 (19%)
KU 325..375 CDD:197529 15/49 (31%)
Kunitz_BPTI 382..433 CDD:278443 21/61 (34%)
NTR_WFIKKN 451..559 CDD:239630 11/28 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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