DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and adamts7

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_021333676.1 Gene:adamts7 / 560364 ZFINID:ZDB-GENE-150720-1 Length:1808 Species:Danio rerio


Alignment Length:1672 Identity:402/1672 - (24%)
Similarity:575/1672 - (34%) Gaps:497/1672 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LCSTALVAFIVLASIHDSQSRFPGLRQKRQYGANMYLPESS-VTPGGEGNDPDE----WTPWSSP 66
            :|||....  |.::.|   ||..|.....:.|.:.:..:.. ||   :|..|:.    |..||..
Zfish   519 ICSTLWCT--VGSTCH---SRLDGAVDGTKCGEDKWCFDGECVT---KGTQPESVHGGWASWSDW 575

  Fly    67 SDCSRTCGGGVSYQTRECLRRDDR-GEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCSRFDRQQF 130
            ||||||||.||....|:|:....: |...|.|..:||.:||.:.||.::..||..|||||:...:
Zfish   576 SDCSRTCGTGVQNAQRDCINPVPKYGGRYCLGERQRYRTCNHESCPVDQPSFRHMQCSRFNTVPY 640

  Fly   131 DGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRC--NDKDLDVCVNGECMPVGCDMM 193
            .|.||:|:...|..|||||:|.|..|.|..|..:.|:|||:|  ..:..|:||||.|..:|||..
Zfish   641 KGKFYKWIHVNNRVNPCELHCRPMNEHFSERMLDTVIDGTQCYEGSQSRDICVNGICKYLGCDFE 705

  Fly   194 LGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACR- 257
            :.|||.||:|..|.|:||||:|:|.|....: ..||.|:.|:||||.:|||||...:.||||.| 
Zfish   706 IDSDAVEDQCGVCLGNGSTCETVRKTFEDSE-GLGYVDIGLIPEGARDIRIEEVAEAGNYLALRS 769

  Fly   258 NHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEKNISL 322
            |....|:|||.|.|.:......|.:.:.|:|.    ...:.|:..||..|.::|.:|.||.|..:
Zfish   770 NDPEKYFLNGGWTIQWNGEYKAAGTIFTYERT----GQLENLSSPGPTMEPVWIQLLFQETNPGV 830

  Fly   323 DYEYSIP-ESLSHSQQDT----HTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQK 382
            .|||:|. ::|..|...|    ..|.:..:..|||:||.|.|.:.|.|..: |...|....||..
Zfish   831 RYEYTISRDTLLDSSNGTAVSYFQWIYGAWTECSATCGTGMQRQIVHCVEK-TSGIVEEHYCDAS 894

  Fly   383 SKPVEEQ-ACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVG 446
            .:|.::| :|....|...|..|:|.|||..||..|.:.|::.|.|.....|....:.|.|     
Zfish   895 MRPDDKQTSCNKGLCPAIWWAGDWQKCSSSCGEMGLRKRTVLCIRSLGLDEQRALQPAEC----- 954

  Fly   447 NKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPET 511
                              .||                                       .|||:
Zfish   955 ------------------QHL---------------------------------------PKPES 962

  Fly   512 EKSCLLTPCEGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKC 576
                 :.||                  ||:.                                .|
Zfish   963 -----IIPC------------------NTQV--------------------------------SC 972

  Fly   577 EAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPG 641
            .|.|.:..||:||..|..|::.|.|.|....|         |.|:.:.||.|...|..::  ||.
Zfish   973 PADWTTGSWSECSVSCATGLRIRDVTCRWNTG---------SDCDPKAKPNSTMPCYAQD--CPI 1026

  Fly   642 EWFTGPWGKCSKPCGGGERVREVLCLSNGTKSVNCD----EEKVEPLSEKCNSEACTED------ 696
            ......|.      |.|...:||.   |....:..|    :.|.:|......::....|      
Zfish  1027 NTDISDWS------GSGASSKEVF---NEIDVIPHDGHFSQTKNQPRQNADLNDIVENDFSHYNH 1082

  Fly   697 -EILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAEDLMQSDSP 760
             |..|..|..|.:..|:...|.:.|:...| ||.|...:|..|..|.       :.:||      
Zfish  1083 IEKSPENSIVKNLHVDDFYYDYNFIKFHED-LSYDLDEDDAFDNSGI-------KHKDL------ 1133

  Fly   761 TPYDEFESTGTTFEGSGYDSESTTDSGISTEGSGDDEETSEASTDLSSSTDSGSTSSDSTSSDSS 825
                    |||      |.|.:|                               |||.||::|..
Zfish  1134 --------TGT------YVSNTT-------------------------------TSSPSTTADQH 1153

  Fly   826 SSISSDATSEAPASSVSDSSDSTDASTE-----TTGVSDDSTDVSSSTEASASESTDVSGASDST 885
            |:.:.             .|||....||     ..|::||:.|...:.:......|.....|..|
Zfish  1154 STATM-------------YSDSITKGTEGHKPPNKGIADDNNDALFAEDYLLPVITTTEPTSSVT 1205

  Fly   886 GSTNASDSTPESSTEASSSTDDSTDSSDNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTTEN 950
            ...|..         .:|.||     ||...::|.:....|::.||..|::            |.
Zfish  1206 RLFNKL---------KASGTD-----SDLMQDISVTRNPLSTADVSLQNEN------------EF 1244

  Fly   951 SSDS--TSDATSDSTASSDSTDSTSDQTTETT----PESSTDSTESSTLDASSTTDASSTSESSS 1009
            .||:  |.:...||..:.::.|...|:..:||    ||   |..|....|...       .||..
Zfish  1245 VSDTFLTPEPDLDSKGNLNNEDDYDDELKDTTKIPIPE---DENEEFGEDVPG-------GESEW 1299

  Fly  1010 ESSTDGS---------------STTSNSA-SSETTGLS-SDGSTTDATTAASDNTDITTDGSTDE 1057
            ||....|               .|..||| .:.||.|. :..|.|.:||..|:..          
Zfish  1300 ESFQPPSFTQPYEPPLDYIFQFETYENSAVQNPTTPLHWNMASPTVSTTRQSNLL---------- 1354

  Fly  1058 STDGSSNASTEGSTEGASEDTTISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSSDVTSDST 1122
                                         |:.|::.......||...|.|...:.....|||:|.
Zfish  1355 -----------------------------SSVSSNDFTKHEPTTNSETSEPWPAVREFTVTSNSL 1390

  Fly  1123 ITDSSPSTEVSGSTDSSSSTDGSSTDASSTEASS-------TDVTESTDSTVSGGTSD------- 1173
            ..:.||::.:.....||.:::..:|....||..|       |.| |..|:.:|..|.|       
Zfish  1391 SQEFSPTSSIPAKHYSSMTSEAGTTALPPTEMESDFEPPIFTPV-EIPDTIISAETYDWYSTAIA 1454

  Fly  1174 -TTESGPTEESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKS 1237
             |..:||..|..  |:|.....                  |:..|.::......|.......|..
Zfish  1455 LTKNNGPRTEPW--GTTVPLPR------------------WTEIDNNEVIIGRIPRPSGLNPTLF 1499

  Fly  1238 KPRKCKPKKSTCAKSEYGCCPDGKSTPKGPFDEGCPIAKTCADTKYGCCLDGVSPAKGKN--NKG 1300
            .|.: :|.:.|  .||:..   ..|:|..|               .|..:..:||:....  |||
Zfish  1500 TPTE-QPSQGT--SSEHSV---HSSSPLMP---------------TGLVMASLSPSASPAHWNKG 1543

  Fly  1301 CPKSQCAETLFGCCPDKFTAADGENDEGCPETTTVPPTTTTEETQPETTTEIEGSGQDSTTSE-- 1363
             ..|.|: |..|......|.:....||...:..|.|........:|.:...|   |:.|..|:  
Zfish  1544 -NWSACS-TSCGLGAIWRTVSCSSGDESDCDLATRPVPARRCYLRPCSAWNI---GEWSKCSKNC 1603

  Fly  1364 -----------PDTKKSCSFSEFGCCPDAETSAKGPDFEGCGLASPVAKGCAESENGCCPDGQTP 1417
                       .||:...|...|.|   ..||.:.|....|.:.|             |.|..|.
Zfish  1604 GVGVKVREIQCHDTRDQRSLRPFHC---QATSPRPPVRIPCNIHS-------------CLDWYTS 1652

  Fly  1418 ASGPNGEGCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARGPNNEGCECHYTP 1482
            :.|...|.|.|..::|...||::..         |..|.|    |.:|        :.|..|   
Zfish  1653 SWGQCSEMCGGGEQQRLVTCPETGR---------CDEDLQ----PSSI--------QSCNVH--- 1693

  Fly  1483 YGCCPDNKSAATGYNQEGCAC----ETTQYGCCPDKITAAKGPKHEGC---------------PC 1528
                |.|:.....:.|...:|    :.....|...|.......:|..|               .|
Zfish  1694 ----PCNQWITGSWGQCSVSCGGGIQRRLVKCVNTKAELEDENEHVDCEHDPRPNNTKKCNVHDC 1754

  Fly  1529 ETTQFG--CCPDGLT--FAKGPHHHG-CHCTQTEFKCCDDEKTPAKG 1570
            ::...|  |..|.||  |.:..|..| |.......|||.....|.:|
Zfish  1755 DSAPSGQLCLRDLLTLRFCQTLHWLGRCQVPSVRVKCCKTCSLPPRG 1801

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559 22/51 (43%)
ADAMTS_CR_3 116..213 CDD:437068 46/98 (47%)
ADAMTS_spacer1 222..329 CDD:461796 40/107 (37%)
TSP1_ADAMTS 347..396 CDD:465950 16/49 (33%)
TSP1_ADAMTS 400..457 CDD:465950 15/56 (27%)
TSP1_ADAMTS 465..520 CDD:465950 5/54 (9%)
TSP1_ADAMTS 580..632 CDD:465950 16/51 (31%)
TSP1_ADAMTS 643..693 CDD:465950 9/53 (17%)
MSCRAMM_ClfA <1049..1262 CDD:468110 40/227 (18%)
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421
Kunitz-type 1730..1780 CDD:438633
Kunitz_BPTI 1789..1840 CDD:425421
Kunitz_papilin_mig6-like 1849..1899 CDD:438679
Kunitz_papilin_mig6-like 1922..1972 CDD:438679
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
adamts7XP_021333676.1 Pep_M12B_propep 68..211 CDD:460254
ZnMc_ADAMTS_like 270..477 CDD:239801
ADAMTS_CR_2 492..556 CDD:465496 9/41 (22%)
TSP1 569..621 CDD:214559 22/51 (43%)
ADAMTS_CR_3 624..725 CDD:437068 46/100 (46%)
ADAMTS_spacer1 727..836 CDD:461796 43/113 (38%)
TSP1_ADAMTS 855..909 CDD:465950 17/54 (31%)
TSP1_ADAMTS 913..967 CDD:465950 22/138 (16%)
TSP1_ADAMTS 976..1024 CDD:465950 17/58 (29%)
Herpes_U47 <1363..>1441 CDD:283192 20/78 (26%)
TSP1_ADAMTS 1540..1588 CDD:465950 12/49 (24%)
TSP1_ADAMTS 1591..1646 CDD:465950 14/73 (19%)
TSP1_ADAMTS 1649..1695 CDD:465950 15/73 (21%)
TSP1_ADAMTS 1698..1754 CDD:465950 6/55 (11%)
Blue background indicates that the domain is not in the aligned region.

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