DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and tfpi2

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001035185.1	Gene:	tfpi2 / 560339	ZFINID:	ZDB-GENE-060503-38	Length:	233	Species:	Danio rerio

Alignment Length:	253	Identity:	75/253 - (29%)
Similarity:	113/253 - (44%)	Gaps:	51/253 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1668 KHVCLLPKSAGPCTGFTKKWYFDVDRNRCEEFQYGGCYGTNNRFDSLEQCQGTCAASENLP-TCE 1731
            |.||||....|.|....:::|::....:||||.|.||.|..|.|.|..:||.||.....:| .|.
Zfish    27 KEVCLLQIEEGTCNDDIQRFYYNTISQQCEEFSYSGCGGNQNNFRSFVECQKTCFRIPKIPQICR 91

  Fly  1732 QPVESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPTEHACNYNCRQPGVLKDRCALPKQT 1796
            ...:.|||.|.|.|::::..:..|.|||||||:||:||:.....|...|:.|..:...|......
Zfish    92 FQKKEGPCRGLFSRYFFNMTSMQCEPFTYGGCQGNENNFRNPEECIEYCKPPKTIPVICLDNLDK 156

  Fly  1797 GDCSEKLAKWHFSESEKRCVPFYYSGCGGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANY 1861
            |.||..:.:::::.:.|.|..|.|:||||:.|||.:.:||.|.|
Zfish   157 GRCSASIPRYYYNSATKTCEEFMYTGCGGSNNNFISKQSCVDVC--------------------- 200

  Fly  1862 VTSWYYDTQDQACRQFYYGGCGGNENRFPTEESCLARCDRKPEPTTTTPATRPQPSRQ 1919
                                  |::...||::|  .|..::     .....:|||||:
Zfish   201 ----------------------GSKRWSPTKKS--VRVSKQ-----YLRRVKPQPSRE 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443	20/50 (40%)
		Kunitz_BPTI	1729..1781	CDD:278443	20/51 (39%)
		Kunitz_BPTI	1789..1840	CDD:278443	18/50 (36%)
		Kunitz_BPTI	1848..1899	CDD:278443	4/50 (8%)
		KU	1920..1973	CDD:238057	75/253 (30%)
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
tfpi2	NP_001035185.1	KU	28..80	CDD:197529	20/51 (39%)
		Kunitz_BPTI	89..141	CDD:278443	20/51 (39%)
		Kunitz_BPTI	149..201	CDD:278443	19/94 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9926
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810