DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and thsd7aa

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_009292626.1 Gene:thsd7aa / 557991 ZFINID:ZDB-GENE-060503-709 Length:1702 Species:Danio rerio


Alignment Length:2441 Identity:453/2441 - (18%)
Similarity:677/2441 - (27%) Gaps:955/2441 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 MGFA--APDQLTCSGPISESLFIVML-------VQEKNISLDYEYSIPESLSHSQQDTHTWTHHQ 346
            ||.|  ||.:...|.....|||.|.|       ||.:.::             :.:.|:.|....
Zfish     1 MGLASRAPGKGGTSAGALASLFRVALLFFGLSDVQTQTVA-------------NTRPTYIWQTGP 52

  Fly   347 FNACSAS-CG-GGSQSRKVTC--NNRITLAEVNPSLCDQKSKPVEEQACGTEPCAPH-----WVE 402
            :..|..| || ||||||.|.|  :...|....|   |.|..:|..:|:| ...|..|     |..
Zfish    53 WGRCMGSECGPGGSQSRAVWCAHSEGWTTLHTN---CQQSERPSNQQSC-FRVCDWHKELYDWQL 113

  Fly   403 GEWSKC----SKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCP 463
            |.|::|    .:..|                     |...|||         |:.|         
Zfish   114 GAWNQCVPVSMRNAG---------------------VPRPAVC---------TRGE--------- 139

  Fly   464 KYHLGPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCV----EEKPETEKSCLLTPCEGVD 524
                           :|.|||:|.|..:.:|    :|.||.:    |.||..|::||: ||.. |
Zfish   140 ---------------EGIQTREVGCVHKSDG----VPAEDAICEYFEPKPRLEQACLI-PCPR-D 183

  Fly   525 WIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCS 589
            .::|::                                                    |.|:.||
Zfish   184 CVVSEF----------------------------------------------------SPWTSCS 196

  Fly   590 APCGKGVKSRIVICGEFDGKTV--TPADDDSKCNKETKPESEQ--DCEGEEKVCPGEWFTGPWGK 650
            ..||.|:::|:        ::|  .|....|.|...|:..:.|  .|||.|.:  .....||||:
Zfish   197 KSCGMGLQNRL--------RSVLAPPLFGGSACPNLTEFRTCQPGKCEGVESL--HSLRVGPWGQ 251

  Fly   651 C-SKPCGGGERVREVLCLSNGTKSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEED 714
            | :.|      :|:         :.:..|.:|.....|...:.....|.......:|    ::::
Zfish   252 CMASP------IRQ---------ARDTGEARVPKAERKAKRDRQARQERQGKRRKNK----EKKE 297

  Fly   715 CDEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYD 779
            ..|...|.:.:.:.:.::..|             ||..:|::                       
Zfish   298 LRESKGERVRERVKEKKRMRD-------------PETRELIK----------------------- 326

  Fly   780 SESTTDSGISTEG-SGDDEETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSD 843
             :..|.:..:.:| ...|.:....:.:::....||||:|.|..:..:..::..|...:....||:
Zfish   327 -KKRTRNRQNRQGLKFWDLQVGYQTREVTCVHRSGSTASISQCTQQTLPVTYQACVISKDCEVSE 390

  Fly   844 SSDSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTNASDSTPESSTEASSSTDDS 908
            .||.:..|                     .|..|::|.......|......|..........::|
Zfish   391 WSDWSVCS---------------------KECYDLNGRKGQRTRTRQVQQFPVGGGAECPELEES 434

  Fly   909 TDSSDNSSNV------SESSTEASSSSV------SDSNDSSD-GSTDGVSSTTENSSDSTSDATS 960
            ...|.....:      :..|||.|...|      .|...|:. |...|...|.|.........||
Zfish   435 EPCSPQGEGIPPCVVYNWRSTEWSDCRVDVLLSQQDRRRSNQTGLCGGGVQTREVYCVQAPSETS 499

  Fly   961 DSTASSDSTDSTSDQTTETTPESSTDSTESSTLDASSTTDASS-------TSESSSESST-DGSS 1017
            .:..|..|.|:.....::.......::|:...:......:.|:       |.|:..:.|| .|..
Zfish   500 SNLGSLKSKDALRPVNSDLCLGVPHNTTQLCHIPCPVECEVSAWSAWGPCTFENCQDQSTKKGFK 564

  Fly  1018 TTSNSASSETTGLSSDGSTTDATTAASDNTDITTDG---STDESTDGSSNASTEGSTEGASEDTT 1079
            .......:|.||  ..|:....|.|.........|.   ..:|....:......|:         
Zfish   565 LRKRKIMNEPTG--GTGNCPHLTEAIPCEEPSCYDWLLVKLEECVPDNDKVCGPGT--------- 618

  Fly  1080 ISTESSGSTESTDAIASDGSTTEGSTVED--LSSSTSSDVT--SDSTITDSSPSTEVS--GSTDS 1138
                   .......|.|||...:.....|  |......:|:  .|..:   ||.|..|  .:|.|
Zfish   619 -------QNPQVQCINSDGEFVDRQLCRDAILPMPVLCEVSCPKDCVL---SPWTSWSLCSNTCS 673

  Fly  1139 SSSTDGSSTDASSTEASSTDVTESTDSTVSGGTSDTTESGPTEESTTEGSTESTTEGSTDSTQST 1203
            ..:::|..|.|.|..|.:..                           :|..:.....:....:|.
Zfish   674 GKNSEGKQTRARSILAYNAG---------------------------DGGVQCPNSSALQEVRSC 711

  Fly  1204 DLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKCKPKKSTCAKSEYGCCPDGKSTPKGPF 1268
            :....|...|.|.......|.::..|.:|.::::.|       .|.....:  |..|..|.|   
Zfish   712 NDHPCTVYHWQTGPWGQCIEDTSVPSANSSISRAVP-------GTAVNDAF--CSVGMQTRK--- 764

  Fly  1269 DEGCPIAKTCADTKYGCCLDGVSPAKGKNNKGCPKSQCAETLFGC-CPDKFTAADGENDEGCPET 1332
                   ..|.....|    .|.|.|      ||:|...||:..| .|             |...
Zfish   765 -------VICVRVNVG----QVPPKK------CPESLRPETVRPCLLP-------------CKRD 799

  Fly  1333 TTVPPTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSCSFSEFGCCPDAETSAKGPDFEGCGLAS 1397
            ..|.|                                  :|::..||..           |....
Zfish   800 CVVTP----------------------------------YSDWTPCPSI-----------CQTGG 819

  Fly  1398 PVAKGCAESENGCCPDGQTPASGPNGEGCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCP 1462
            .|.|  .:|......  |.||:|  |:.|.....:...|...|..|.:                 
Zfish   820 SVKK--KQSRKRIII--QLPANG--GQDCPEVLFQEKDCDASSVCPGY----------------- 861

  Fly  1463 DNILAARGPNNEGCECHYTPYGCCPDNKSAATGYNQEGCACETTQYGCCPDKITAAKGPKHEGCP 1527
                  |...::...|...|:....|:..|     ||.|                ..|.:.....
Zfish   862 ------RWKTHKWRRCQLVPWSIRQDSPGA-----QETC----------------GPGLQARAVS 899

  Fly  1528 CETTQFG-----CCPDGLTFAKGPHHHGCHCTQT-EFKCCDDEKTPAKGPNGDGCTCVESKFGCC 1586
            |:....|     .|   |.|| ||..   ..||: :..|.||.:..|           .|||..|
Zfish   900 CKKLDSGPADVAAC---LKFA-GPMP---QLTQSCQLPCQDDCQLTA-----------WSKFSTC 946

  Fly  1587 PDGVTKATDEKFGGCENVQEPPQKACGLPKETGTCNNYSVKYYFDTSYGGCARFWYGGCDGNDNR 1651
                  |.|     |..|:...:...|..|:...|.|..:....:|.|                 
Zfish   947 ------AAD-----CVGVRTRKRTLVGKSKKREQCKNTQMYPLSETQY----------------- 983

  Fly  1652 FESEAECKDTCQDYTGKHV-----CLLPKSAGPCTGFT-KKWYFDVDRNRCEE---FQYGGCYGT 1707
                  |  .|..|..:.|     |:||:  |...|.. .|...|:  ..|.:   :|...||..
Zfish   984 ------C--PCNKYNAQPVGNWSDCILPE--GRVEGLLGMKVQGDI--KECGQGYRYQAMVCYDQ 1036

  Fly  1708 NNRFDSLEQCQGTCAASENLPTCEQPVESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPT 1772
            :||.                      ||:..|                          |.:.| .
Zfish  1037 DNRL----------------------VETSRC--------------------------NSHGY-I 1052

  Fly  1773 EHACNYNCRQPGVLKDRCALPKQTGDCSEKLAKW-HFSESEKRC-------------VPFYYSG- 1822
            |.||...|               ..||  ||::| ::|...|.|             .|  |:| 
Zfish  1053 EEACIIPC---------------PSDC--KLSEWSNWSRCSKSCGSGVKVRSKWLREKP--YNGG 1098

  Fly  1823 --CGGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYV------TSWYYDTQDQACRQFYY 1879
              |       |.|    ||..:   ..:.|:...:.:|:.||      :.|.....|      ..
Zfish  1099 RPC-------PKL----DHVNQ---AQVYEVVPCLSDCSQYVWVAEPWSVWKVSNVD------LK 1143

  Fly  1880 GGCGGNENRFPTEESCLARCDRKPEPTTTTPATRPQPSRQDVCDEEPAPGECSTWVLKWHFDRKI 1944
            ..||         |....|..|..:.|...|:   .|....:||.|..|                
Zfish  1144 ENCG---------EGVQTRKVRCMQNTVDGPS---DPVEDYLCDPEEMP---------------- 1180

  Fly  1945 GACRQFYYGNCGGNGNRFETENDC-------QQRCLSQEPPAP-----TPPRAPAPTRQPDPAPT 1997
                      .|...::.....||       ..||     |.|     |..|:.:|.|||...  
Zfish  1181 ----------LGARESKLPCPEDCVLTDWGSWSRC-----PLPCNVNSTRQRSASPIRQPSER-- 1228

  Fly  1998 VAQCSQPADPGQC--DKWALHWNYNETE-GRCQSFYYGGCGGNDNRFATEEECSARCSVNIDIRI 2059
             .||....:...|  :....|::||.|: ..||              .:|.   |.|.|....|:
Zfish  1229 -KQCPSTTEKEICTLNSNCFHYSYNITDWSTCQ--------------LSER---AVCGVGFKTRM 1275

  Fly  2060 GADPVEHDTSKCFLAFEPGNCYNNVTRWFYNSAEGLCDEFVYTGCGGNANNYATEEECQNECNDA 2124
             .|.|..|:....|.|                    |:|.      |....:.....|..||   
Zfish  1276 -LDCVRSDSKSVDLKF--------------------CEEL------GLEKKWQMNASCVVEC--- 1310

  Fly  2125 QTTCALPPVRGRCSDLSRRWYFDERSGEC-HEFEFTGCRGNRNNFV--SQSDCLNFCIGEPVVEP 2186
                   ||..:.||.| .|      .|| |.....|....|...:  ||.|      |.|    
Zfish  1311 -------PVNCQLSDWS-SW------SECSHTCGLAGKLWRRRTVIQASQGD------GRP---- 1351

  Fly  2187 SAPTYSVCAEPPEAGECDNRTTAWFYDSENMACTAFTYTGCGGNGNRFETRDQCERQCGEFKGVD 2251
                            |.::...|                                         
Zfish  1352 ----------------CSSQLEQW----------------------------------------- 1359

  Fly  2252 VCNEPVTTGPCTDWQTKYYFNTASQACE-----PFTYGGC---DGTGNRFSDLFECQTVCLAGRE 2308
               :|....||..|:...:....|:...     .|....|   ||:|.....:.: :.:| ...|
Zfish  1360 ---KPCPVKPCFSWRYSVWSPCKSEGARCGEGLRFRNVSCFVSDGSGKDAGSMVD-EELC-GDLE 1419

  Fly  2309 PRVGSAKEICLLPVATGRCNGPSVHERRWYYDDEAGNCVSFIYAGC-----SGNQNNFRSFEACT 2368
            ..|...|:|.|....|..|.|      ..|..|..      :::.|     .|:...|.|.:..:
Zfish  1420 QTVDGDKQIILQESCTVPCPG------ECYLTDWT------MWSPCQLSCIGGDDLGFGSVQVRS 1472

  Fly  2369 N-----------QCRPEPNKQDNEIGQNPCDTFDAECQELRCPYGVRRVAARSQPECTQCICENP 2422
            .           || ||     .|....||.  :.:|.:.:...|..|.::|      |..|:. 
Zfish  1473 RAVLAQEPENLLQC-PE-----QEWEARPCT--EGQCYDYKWMTGAWRGSSR------QVWCQR- 1522

  Fly  2423 CEGYSCPEGQQCAIDVASSDDRQFAPVCRDIYKPGECPALSANASGCARECYTDADCRGDNKCCS 2487
            .:|.:...|.|...:..|  ||...|.|.   ||... ...|...|| .|.||:.       ..|
Zfish  1523 SDGLNVTGGCQSTTEPVS--DRSCDPACD---KPRSI-CTEAGICGC-EEGYTEV-------MTS 1573

  Fly  2488 DGCGQLCVHPARPTQPPRTQAPVVSYP--GDARAALEPKEAHELDVQTAIGGIAVLRCFATGNPA 2550
            ||....|           |..||:..|  ||::|          ||:|       :|......|.
Zfish  1574 DGVLDQC-----------TVIPVLEIPTAGDSKA----------DVKT-------IRALNPTEPT 1610

  Fly  2551 PNI------TW---------SLKNLVINTNKGRYVL 2571
            .|:      ||         .||..|.....|.:||
Zfish  1611 ANMPGRAGRTWFLQPFGPDGKLKTWVYGVAAGAFVL 1646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607 13/46 (28%)
TSP1 468..521 CDD:214559 17/56 (30%)
TSP_1 645..693 CDD:278517 10/48 (21%)
Kunitz_BPTI 1611..1663 CDD:278443 7/51 (14%)
Kunitz_BPTI 1670..1721 CDD:278443 14/59 (24%)
Kunitz_BPTI 1729..1781 CDD:278443 8/51 (16%)
Kunitz_BPTI 1789..1840 CDD:278443 15/67 (22%)
Kunitz_BPTI 1848..1899 CDD:278443 9/56 (16%)
KU 1920..1973 CDD:238057 8/59 (14%)
Kunitz_BPTI 2001..2051 CDD:278443 10/52 (19%)
KU 2071..2121 CDD:238057 6/49 (12%)
Kunitz_BPTI 2127..2178 CDD:278443 14/53 (26%)
KU 2192..2245 CDD:238057 2/52 (4%)
KU 2251..2304 CDD:238057 10/60 (17%)
KU 2316..2372 CDD:238057 12/71 (17%)
WAP 2457..2497 CDD:278522 10/39 (26%)
Ig 2521..2610 CDD:299845 14/66 (21%)
IG_like 2530..2610 CDD:214653 14/57 (25%)
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
thsd7aaXP_009292626.1 TSP1 186..236 CDD:214559 15/109 (14%)
TSP1 388..440 CDD:214559 12/72 (17%)
TSP1 660..716 CDD:214559 13/82 (16%)
TSP1 1067..>1105 CDD:214559 10/50 (20%)
TSP1 1317..1367 CDD:214559 17/126 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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