DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and vwa10.2

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_685294.5	Gene:	vwa10.2 / 557188	ZFINID:	ZDB-GENE-090313-295	Length:	990	Species:	Danio rerio

Alignment Length:	932	Identity:	195/932 - (20%)
Similarity:	310/932 - (33%)	Gaps:	276/932 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 EGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFS-SE 584
            ||.|.|.|..|...|..            |:|.......      ||...|.:.:   .::| |.
Zfish   127 EGRDLITSAVSSVKASA------------KQGSYISARI------TLGALCHTLQ---DFYSHSN 170

  Fly   585 WSKC--SAPCGKGVKSRIVICGEFDGKTVT-PADDDSKCNKETKPESEQDCEGEEKVCPGEWFT- 645
            |.:.  |||....:|..:.:....|..|.| .|..:..|.....||:::...|        :|:
Zfish   171 WVELGNSAPFSTLIKPELPLDNVADLSTPTCKACTEGNCIYNLLPENKKLTSG--------YFSL 227

  Fly   646 ----GPWGKCSKPCGGGERVREVLCLSNGTKSVNCDE---------EKVEPLSEKCNSEACTEDE 697
                .|.||||.   ||.  .::...::.|..:|.|:         .:...|:.:...: ..||.
Zfish   228 YSSKKPAGKCSH---GGS--ADMTSSADPTGGINKDDIYSSHGFLHPQAADLAIRATMD-MLEDI 286

  Fly   698 ILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAE-----DLMQS 757
            .:.:.|  ||.           ::|:  |:|.......|||..|:...:.  ||.     .::.|
Zfish   287 RMAIGS--KPF-----------LQLM--GISQTSVLAFVIDTTGSMSDDI--EAAKSVSFSIIDS 334

  Fly   758 DSPTPYDEFESTGTTFEGSGYDSESTTD---------SGISTEGSGDDEETSEASTDLSSSTDSG 813
            ...||.:..|.....|....:...:.||         :.::.||.||..|...:...|:.:....
Zfish   335 RRGTPQEPSEYILVPFNDPDFGPLTRTDNADIFKKRLTSLTAEGGGDFPEMCLSGLLLALAGAPP 399

  Fly   814 STS----SDSTSSDSSSSISSDATSEAPASSVSDSSDSTDASTETTGVSDDSTDVSSSTEASASE 874
            |:.    :|:|:.||.......|..|...|:|:.....:.:......||......|.|...|
Zfish   400 SSDIFVFTDATAKDSELGSIVQAMIERTKSTVTFMLTGSFSYRRRRAVSQSQQFTSRSLFQS--- 461

  Fly   875 STDVSGASD----STGSTNASDSTPESSTEASSS--TDDSTDS-------------SDNSSNVSE 920
              |:....|    |.|.|   ...|:|:...:::  ||.||.:             ::|.|.|.:
Zfish   462 --DIQLYRDLAHVSGGQT---IEVPKSTLSQATAVITDSSTSALVTILQVVRSPAIAENFSIVLD 521

  Fly   921 SS---------------TEASSSSVSDSNDSSD---------GSTDGVSSTTEN-------SSDS 954
            ||               |..|.:.||.|...::         |:...:..::||       |.::
Zfish   522 SSLSNVTVYITGDSPFFTLYSPTGVSQSGSVANGLLGSILTVGNLKRIKLSSENQKGEWRISINA 586

  Fly   955 TS----DATSDSTAS--------SDSTDST--------------------SDQTTET---TPESS 984
            ||    ..|::|:.:        |.|:|.|                    .|..|.|   ..|:|
Zfish   587 TSFYSLKVTAESSVNFLFNFVEQSQSSDFTPKANRPFIGRNATLFVSVTGGDSVTVTDVLLVEAS 651

  Fly   985 TDSTESSTLDASSTTD-------------------------ASSTSESSSESSTDGSSTTSNSAS 1024
            ..:..:.|:.|..|||                         |.|..:..|.:...||..|..:..
Zfish   652 GSAVVNGTIKAVGTTDFLVNIDTIPEWAFVVQLRGLFNDSLAVSRFQRQSPTQQQGSKLTIKAQP 716

  Fly  1025 SET--TGLSSDGSTTDATTAASDNTDITTDGSTDESTDGSSNASTEGS----TEGASEDTTISTE 1083
            |.|  .|:..|.:.|...||...|..|..      .||.:.|.|...|    .||:::.|.....
Zfish   717 SSTIEPGIPLDLNFTLVNTATGGNYTIRA------RTDRNFNVSFPNSLIIGAEGSAQGTVTLIA 775

  Fly  1084 SSGSTESTD--------AIASDGST------TEGSTVEDLSSSTSS--DVTSDSTITDSSPSTEV 1132
            .||:...||        |.||..|.      |..:.|.|||.....  .:.:|..|..||...|:
Zfish   776 PSGTDSGTDVTLTIEAEAPASGDSNYLALRFTVMNKVTDLSRPVCQIVRIKADCPIECSSALWEL 840

  Fly  1133 SGS-TD---------SSSSTDGSSTDASSTEASSTDVT---------------ESTDSTVSGGTS 1172
            |.: ||         |.:|.:||.:.::....:.|:||               .:.|...:.||.
Zfish   841 SANLTDGNGTGIAGVSINSGNGSLSLSTVMSENGTNVTLVSYNASCCSQDVELVAVDKVGNVGTC 905

  Fly  1173 DTTESGPTEESTTEGSTESTTEGSTDSTQSTDLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKS 1237
            ..:...||...:..|||..:   .|.||.:..::|.:..            :|.|.|....|:.|
Zfish   906 FASIRSPTSTISPSGSTSIS---QTQSTAAVPIESASVG------------TSEPASLSHSVSTS 955

  Fly  1238 KPRKCKPKKSTCA--KSEYGCC 1257
            ..:.......:||  ...|..|
Zfish   956 ISQNQSTTAGSCASYSVSYSMC 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559	195/932 (21%)
		TSP_1	645..693	CDD:278517	11/61 (18%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
vwa10.2	XP_685294.5	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900