DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and si:dkey-24p1.1

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001091715.1	Gene:	si:dkey-24p1.1 / 556718	ZFINID:	ZDB-GENE-060503-631	Length:	1043	Species:	Danio rerio

Alignment Length:	679	Identity:	140/679 - (20%)
Similarity:	222/679 - (32%)	Gaps:	236/679 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2342 EAGNCVSFIYAGCSGNQNNFRSFEACTNQCRPEP----NKQDN-EIGQNPCDTFDAECQELRCPY 2401
            ::|| .||.|.|                   |:|    :|..| .:..|||..: .|..||:.|
Zfish   127 DSGN-YSFRYIG-------------------PDPHIFMSKAMNLTVTDNPCKVY-IEPSELKNP- 169

  Fly  2402 GVRRVAARSQPECTQCICENPCEGYSCPEGQQCAIDVASSDDRQFAPVCRDIYKPGECPALSANA 2466
                 ...|.....||....||:  |.||..                    ::|.|:.|..:::.
Zfish   170 -----LKESDKFTVQCFTSGPCD--SPPEWL--------------------LFKSGQTPEWTSSP 207

  Fly  2467 SGCARECYTDAD----------------CRGDNKCCS-------DGCGQLCVHPARPTQPPRTQA 2508
            |   :|...:.:                .:.||:..|       |.| |:           |...
Zfish   208 S---KEMIIETEKGENGTQVTKLKLTVTWKDDNRILSCRPANSDDSC-QI-----------RNIT 257

  Fly  2509 PVVSY-PGDARAALEPKEAHELDVQTAIGGIAVLRCFATGNPAPNITWSLKNLVINTNKGRYVLT 2572
            ..|.| |.:..|::...:..|.:..|       |.|.:.|.|....||..|      |||:  |.
Zfish   258 LSVEYSPKETHASVSSNDVKETNSVT-------LSCTSRGRPEVTYTWFKK------NKGK--LQ 307

  Fly  2573 ANGDLTIVQVRQTDDGTYVCVASNGLGEPVRREVALQVTEPVSQPAYIYGDKNVTQIVELN---- 2633
            ...||.:.|::..|.|.|.|.|.|.||.....|:::.|.         :|.|.||.....|
Zfish   308 QISDLDLRQMKPEDSGEYYCEAKNSLGVMKSNEISINVK---------FGPKGVTVTPPYNINDI 363

  Fly  2634 ---RPAVIRC-------PAGGFPEPHVSWWRNGQMFGLKNNLMARDYSLVFNSIQL-SDLGLYTC 2687
               ....::|       ||..|     .|:        |||.:.::.|..|...:: :.:..|.|
Zfish   364 KEGDTVTLKCSVERQNPPASRF-----VWY--------KNNRIQQETSETFIDRKVTAAVQKYKC 415

  Fly  2688 EVYN-----QRRPVSLRV------------TLKAVGPVRPLSPEEEQYMQYV----------LNP 2725
            |..|     |.:.:::.|            |...||....|:...:.:.|.|          .:|
Zfish   416 EANNGINKGQSQELTVNVKYSPRNINIQGKTSVKVGSRLELTCSADAHPQPVYKWTFPPGLSFSP 480

  Fly  2726 ------ATRPVTQRPSYPY-----------RPTRPAYVPEPTVNVHAVLALEPKNSYTPGSTIVM 2773
                  .|:|||...:..|           ..:....|..|..|::.::..|.:..    ..|.:
Zfish   481 LSKGKLETQPVTIEHAGEYTCGVTNTIGTKSESTNVKVLYPPRNINLMMQSEVREF----EVISV 541

  Fly  2774 SCSVQGYPEPNVTWIKDDVPLYN---NERVQITYQPHRLVLSDVTSADSGKYTCRASNAYTYANG 2835
            .|:||.:|....|..|:...|.|   ..|....|:...::..:||.:|:|.|.|.|.|    ..|
Zfish   542 ICTVQSFPTSKFTVTKNLDNLLNIPECRRNSTEYENKVIIFLNVTESDAGTYKCTAKN----TEG 602

  Fly  2836 EANVSIQSVVPVSPECVDNPYFANCK----LIVKGRYCSNPYYT--------------------- 2875
            :...:.:..|..:|:.|...:..:.|    |.:....||||..:
Zfish   603 QEETNKKLTVLYAPKNVTASFKGDQKSASELTLTCEACSNPPVSSYEWTKLNNGQFETLKQHQQL 667

  Fly  2876 -----------QFCCRSCTLAGQVASPPL 2893
                       |:.|.:....|:..||||
Zfish   668 HFNSLEISDSGQYVCIAYNAIGKAKSPPL 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057	6/29 (21%)
		WAP	2457..2497	CDD:278522	10/62 (16%)
		Ig	2521..2610	CDD:299845	25/88 (28%)
		IG_like	2530..2610	CDD:214653	24/79 (30%)
		IG_like	2627..2703	CDD:214653	19/107 (18%)
		Ig	2636..2701	CDD:143165	16/89 (18%)
		IG_like	2766..2841	CDD:214653	20/77 (26%)
		Ig	2768..2830	CDD:299845	19/64 (30%)
		PLAC	2851..2883	CDD:285849	9/67 (13%)
si:dkey-24p1.1	NP_001091715.1	Ig	37..153	CDD:299845	10/45 (22%)
		IG_like	276..345	CDD:214653	25/83 (30%)
		IGc2	280..334	CDD:197706	21/68 (31%)
		IG_like	364..431	CDD:214653	15/79 (19%)
		Ig_2	365..433	CDD:290606	15/80 (19%)
		IG_like	443..518	CDD:214653	12/74 (16%)
		IGc2	451..508	CDD:197706	10/56 (18%)
		IG_like	532..612	CDD:214653	21/87 (24%)
		Ig	<570..602	CDD:299845	10/35 (29%)
		IG_like	616..694	CDD:214653	11/77 (14%)
		Ig_2	631..700	CDD:290606	12/66 (18%)
		IG_like	721..791	CDD:214653
		Ig_2	721..785	CDD:290606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900