DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and paplnb

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001018400.1	Gene:	paplnb / 553586	ZFINID:	ZDB-GENE-030131-6023	Length:	548	Species:	Danio rerio

Alignment Length:	655	Identity:	175/655 - (26%)
Similarity:	236/655 - (36%)	Gaps:	208/655 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 EWTPWSSPSDCSRTCGGGVSYQTREC--LRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQ 121
            |:.|:   ..|||||||||:.:||.|  :|.|  |...|.|.|:.|..||||:||....|||.:|
Zfish    29 EYGPY---GPCSRTCGGGVAVRTRICNTMRTD--GGHNCVGPSKSYKLCNTQECPAGSRDFREEQ 88

  Fly   122 CSRFDRQQFDGVFYEWVPYTNAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECM 186
            ||.||:..|.|..|.|.||..|.|||||.|:|:||.||||.|..|||||.|:....||||.|.|.
Zfish    89 CSHFDQMTFQGKRYTWQPYYGASNPCELVCVPRGENFYYRHRPAVVDGTLCHVGRRDVCVEGVCR 153

  Fly   187 PVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSS 251
            .|....::|.   ||               |:...|....||         .|.::
Zfish   154 AVSHGEIVGF---ED---------------RDIPVTSRHGPG---------AAVHL--------- 182

  Fly   252 NYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQ 316

Zfish   183 ----------------------------------------------------------------- 182

  Fly   317 EKNISLDYEYSIPESLSHSQQDTHTWTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQ 381
                                 ||:.:|:..::.||..||||.|||.|.|.:..|.|.|:.|.|..
Zfish   183 ---------------------DTYRYTYSAYSECSRLCGGGVQSRTVYCVHERTSAMVDESHCIA 226

  Fly   382 KS--KPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKE 444
            |.  ||..:.||....|| .:..|.:..||..|| :|.|.|.:.|  :...||...|.....|
Zfish   227 KGLRKPTAQVACNEHACA-EYSAGPFGDCSVTCG-EGLQTREVIC--VGGRGERLSEHHCSGL-- 285

  Fly   445 VGNKPATKQECNRDVKNCP---KYHLGPWTPCDKLCGDGKQTRKVTCF-IEENGHKRVLPEEDCV 505
              .:|...:.|.|..  |.   :|:...::.|.:.||.|.:.|:|.|. ::::.:.    ::.|.
Zfish   286 --TRPQDTKACKRPA--CHQVFRYYTNDFSLCTRSCGTGTRERRVVCMDLDQHPYS----DDRCA 342

  Fly   506 E-EKPETEKSCLLTPCEGVDWIISQWSGCNACGQNTETRTAICGNKEGKVYPEEFCEPE--VPTL 567
            . .:|...::|...||.|...:.|..   |..|..:..|..:.....    |.....|.  .||:
Zfish   343 SLSRPHAVENCNTQPCPGPQTVPSVQ---NPNGYESSLRGFLSYTHS----PVSVYRPSDPYPTV 400

  Fly   568 SRPCKSPKCEAQWFSSEWSKC-------SAPCGKGV------KSRIVICGEFDGKTVTPADDDSK 619
            :    .|.| ||   |.:..|       |.|.|:|.      :||...|  .||.|.......:.
Zfish   401 T----GPHC-AQ---SHYGCCPDGHTTASGPRGEGCAHDDCQRSRYGCC--LDGITAALGYRRAG 455

  Fly   620 CNKETKPESEQ-DCEGEEKVCPGEWFTGPW-------------GKCSKPCGGGERVREVLCLSNG 670
            |     |:|.. |......||......||.             |.||:...||       |..||
Zfish   456 C-----PDSSYGDHSPSASVCSLARDVGPCYEYKSRFYFDHSSGSCSQFWFGG-------CQGNG 508

  Fly   671 TKSVN 675
            ...|:
Zfish   509 NNFVS 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	24/52 (46%)
		ADAM_spacer1	214..329	CDD:283607	5/114 (4%)
		TSP1	468..521	CDD:214559	11/54 (20%)
		TSP_1	645..693	CDD:278517	11/44 (25%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
paplnb	NP_001018400.1	TSP1	28..78	CDD:214559	25/53 (47%)
		TSP1	249..300	CDD:214559	16/59 (27%)
		TSP1	309..359	CDD:214559	11/53 (21%)
		Kunitz_BPTI	470..522	CDD:278443	13/51 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10884
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D36783at33208
OrthoFinder	1	1.000	-	-		FOG0005760
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.780