DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Hmcn1

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:XP_006529820.1 Gene:Hmcn1 / 545370 MGIID:2685047 Length:5658 Species:Mus musculus


Alignment Length:1368 Identity:281/1368 - (20%)
Similarity:414/1368 - (30%) Gaps:460/1368 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   274 PRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQEKNISLDYEYSIPESLSHS--- 335
            |:|..    .|:.|.:|:.:   |......| :.||:|.  ...|..:.:|| .:..:|..|   
Mouse  4490 PQPTI----TWSRQGQPISW---DNRLSMLP-NSSLYIA--AARKEDTSEYE-CVARNLMGSVLV 4543

  Fly   336 QQDTHTWTHHQFN------ACSASCGGGSQSRKVTCNNRITLAEVNPSLC---DQKSKPVEEQAC 391
            :.......|..|:      .||.:||.|.|.|...|:|........|  |   |.:::....:.|
Mouse  4544 RVPVIVQVHGGFSLWSAWRPCSVTCGKGIQKRSRLCDNPPPANGGRP--CQGADSEARHCHNKLC 4606

  Fly   392 GTEPCAPHWVEGE-WSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQE- 454
               |...||.|.. |..||:.|| .|.|.|:.||.  :...:|            |.:|..... 
Mouse  4607 ---PVDGHWSEWSFWEDCSRSCG-HGNQTRTRTCS--NPPAQH------------GGRPCEGHAV 4653

  Fly   455 ----CNRDVKNCPKYHL----GPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPE- 510
                ||  ::.||.:.:    .||:.|.|.||.|.|||...|    |..........|...:.: 
Mouse  4654 ETIMCN--IRPCPVHGVWNAWQPWSACSKSCGKGSQTRMRLC----NNPPPSFGGAHCSGAETQM 4712

  Fly   511 ---TEKSCLLTPCEG--VDWIISQWSGCN-ACGQNTETRTAIC--------GNK-EGKVYPEEFC 560
               .|:.|   |.:|  ..|  |.||.|. :||.....||..|        ||| ||.....:||
Mouse  4713 QVCNERHC---PVDGRWATW--SSWSACTVSCGGGARKRTRDCSDPVPQYGGNKCEGTGVQSDFC 4772

  Fly   561 EPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETK 625
            .      |.||.:....:.|  |.|..||..|..|...|...|     ....|::....|.   .
Mouse  4773 N------SDPCPTHGNWSPW--SGWGTCSRTCNGGQMRRYRTC-----DNPRPSNGGRACG---G 4821

  Fly   626 PESE-QDCEGEEKVCP--GEWFT-GPWGKCSKPCGGGERVREVLC----LSNGTKSVNCDEEKVE 682
            |::: |.|..:  :||  |.|.| ..|..||..||||||.|:.||    .:.|.:|...|..:| 
Mouse  4822 PDTQIQRCNTD--MCPVDGSWGTWHSWSHCSVSCGGGERTRKRLCDNPVPTKGGRSCPGDATQV- 4883

  Fly   683 PLSEKCNSEACTEDEILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVIDLEGTAKTET 747
               .:||.:||                                                      
Mouse  4884 ---SRCNMQAC------------------------------------------------------ 4891

  Fly   748 TPEAEDLMQSDSPTPYDEFESTGTTFEGSGYDSESTTDSGISTEGSGDDEETSEASTDLSSSTDS 812
                          |.....:.|                  |..|:.:|.|...|..:       
Mouse  4892 --------------PGGPQRARG------------------SVIGNINDIEFGIAFLN------- 4917

  Fly   813 GSTSSDSTSSDS---SSSISSDATSEAPA-------------SSVSDSSDSTDASTETTGVSDDS 861
             :|.:||.::|:   .:.|::...|..||             ::..:..::.:..|.|..|....
Mouse  4918 -ATITDSPNTDTRVIQAKITNVPRSLGPAMRKIISILNPIYWTTAKEIGEAVNGFTLTNAVFKRE 4981

  Fly   862 TDVSSSTEASASESTDVSGASDSTGS----TNASDSTPESSTEASSSTDDSTDSSDNSSNVSESS 922
            |.|..:| ......|.|:...||.|:    ...|....:..:.|.....|.|   ::........
Mouse  4982 TQVEFAT-GEVLRMTHVARGLDSDGALLLDVIVSGQVLQLHSPAEVGVKDYT---EDYIQTGPGQ 5042

  Fly   923 TEASSSSVSDSNDSSDGSTDGVS-STTENSSDSTSDATSD-----STASSDSTDSTSDQTTETTP 981
            ..|.|:.:.        :.||:| ..|.|.:.....|...     .|..:.|.:|..:|..||..
Mouse  5043 LYAYSTRLF--------TIDGISIPYTWNHTIFYDQAWGKMPFLVETLHASSIESDYNQLEETLG 5099

  Fly   982 ESSTDSTESSTLDASSTTDASSTSESSSESSTDGSSTTSNSASSET-------------TGLSSD 1033
            .....|....  |.|:...:....:|......|....|:.:..|.|             .||:  
Mouse  5100 FKIHASISKG--DRSNQCPSGFILDSVGPFCADEDECTAGNPCSHTCHNAIGAYYCSCPKGLT-- 5160

  Fly  1034 GSTTDATTAASDNTDITTDGSTDESTDGSSNASTEGST--EGASEDTTISTESSGSTESTDAIAS 1096
                           |..||.|.:..|   ..:..|.|  .|...|.||.        |...:..
Mouse  5161 ---------------IAADGRTCQDID---ECALGGHTCRAGQDCDNTIG--------SYRCVVH 5199

  Fly  1097 DGS----TTEGSTVEDLSSSTSSDVTSDSTITDSSPSTE----VSGSTDSSSSTDGSSTDASSTE 1153
            .|:    |::|.:.:|::.           ..:|||..:    |.||...     |.........
Mouse  5200 CGTGFRRTSDGLSCQDINE-----------CQESSPCHQRCFNVIGSFHC-----GCEAGYQLKG 5248

  Fly  1154 ASSTDVTESTDS---------TVSGGTS--DTTESGPTEESTTEGSTESTTEGSTDSTQSTDLDS 1207
            ....||.|...:         ...||..  |...||.|:..                      :.
Mouse  5249 RKCIDVNECRQNVCRPDQHCKNTRGGYKCIDLCPSGMTKAE----------------------NG 5291

  Fly  1208 TTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKCKPKKSTCAKSEYGC-CP-----DGKSTPKG 1266
            |..||       ||.:..|.....:::.::            .:..|.| ||     .|...|..
Mouse  5292 TCIDI-------DECKDGTHQCRYNQICEN------------TRGSYRCACPRGYRSQGVGRPCI 5337

  Fly  1267 PFDEGCPIAKTCADTKYGCCLDGVSPAKGKNNKGCPKSQCAETLFGCCPDKFTAADGENDEGCPE 1331
            ..:|...:.|.||   :.|          .|:.|..|  |.     |.|.:....||::..|...
Mouse  5338 DINECEQVPKPCA---HQC----------SNSPGSFK--CI-----CLPGQQLLGDGKSCAGLER 5382

  Fly  1332 TT---TVPPTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSCSFSEF---------------GCC 1378
            .:   |...:.|.|...|     :....|.|......::...|:||:               ..|
Mouse  5383 LSNYGTQYSSYTLERFSP-----VRSDYQPSQHYRQYSQLYSSYSEYRNSRASFSRNRRTIRKTC 5442

  Fly  1379 PDA-----ETSAKGPDFEGCGLASPVAKGCAE---SENGCCPDGQTPASGPNGEGCSG---CTRE 1432
            |:.     ||..   |.:.|.........|..   |....||.|.....  ||:.|..   |..:
Mouse  5443 PEGSEANHETCV---DIDECQNRDTCQHECKNTIGSYQCVCPPGYRLML--NGKTCQDVDECLEQ 5502

  Fly  1433 RFGCCPDSQTPAHGPNKEGC--------CLDTQFGCCPDN---------ILAARGPNNEGCECHY 1480
            ...|         |||:. |        |:||.   ||.|         .|....||:  .||..
Mouse  5503 NVRC---------GPNRM-CFNMRGSYQCIDTP---CPPNYQRDPVLGFCLKNCPPND--LECTL 5552

  Fly  1481 TPY 1483
            :||
Mouse  5553 SPY 5555

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607 13/54 (24%)
TSP1 468..521 CDD:214559 16/56 (29%)
TSP_1 645..693 CDD:278517 19/52 (37%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Hmcn1XP_006529820.1 vWFA 42..198 CDD:238119
Ig 520..608 CDD:386229
Ig 612..696 CDD:386229
I-set 702..789 CDD:369462
I-set 793..884 CDD:369462
Ig 890..977 CDD:386229
Ig 980..1071 CDD:386229
I-set 1085..1167 CDD:369462
I-set 1171..1257 CDD:369462
Ig 1266..1354 CDD:386229
I-set 1368..1447 CDD:369462
IG_like 1459..1541 CDD:214653
Ig 1564..1632 CDD:386229
I-set 1644..1728 CDD:369462
I-set 1751..1821 CDD:369462
Ig 1843..1935 CDD:319273
Ig 1949..2031 CDD:386229
Ig 2044..2115 CDD:386229
I-set 2134..2214 CDD:369462
I-set 2226..2309 CDD:369462
Ig_3 2313..2390 CDD:372822
Ig 2429..2491 CDD:319273
I-set 2501..2590 CDD:369462
I-set 2605..2686 CDD:369462
I-set 2704..2785 CDD:369462
Ig 2818..2881 CDD:319273
I-set 2902..2983 CDD:369462
I-set 3005..3075 CDD:369462
I-set 3087..3170 CDD:369462
Ig 3192..3260 CDD:319273
Ig 3267..3361 CDD:386229
I-set 3377..3453 CDD:369462
I-set 3468..3546 CDD:369462
IG_like 3558..3639 CDD:214653
I-set 3652..3732 CDD:369462
I-set 3736..3823 CDD:369462
Ig 3846..3912 CDD:319273
Ig 3937..4004 CDD:319273
Ig 4028..4090 CDD:319273
I-set 4102..4188 CDD:369462
Ig 4209..4276 CDD:319273
I-set 4283..4368 CDD:369462
Ig 4387..4458 CDD:386229
I-set 4463..4549 CDD:369462 15/69 (22%)
TSP1 4556..4607 CDD:214559 13/55 (24%)
TSP1 4612..4664 CDD:214559 17/68 (25%)
TSP1 4669..4721 CDD:214559 15/58 (26%)
TSP1 4726..4778 CDD:214559 19/59 (32%)
TSP1 4783..4835 CDD:214559 14/63 (22%)
TSP1 4840..4892 CDD:214559 22/123 (18%)
G2F 4891..5115 CDD:214774 48/331 (15%)
EGF_CA 5130..5169 CDD:214542 10/55 (18%)
EGF_CA 5170..5213 CDD:311536 11/53 (21%)
EGF_CA 5215..5252 CDD:214542 8/52 (15%)
EGF_CA 5253..5286 CDD:238011 8/32 (25%)
EGF_CA 5295..5336 CDD:311536 10/59 (17%)
EGF_CA 5338..5377 CDD:214542 13/58 (22%)
EGF_CA 5455..5494 CDD:214542 9/40 (23%)
EGF_CA 5495..5531 CDD:214542 12/48 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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