DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and App

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_062161.1	Gene:	App / 54226	RGDID:	2139	Length:	770	Species:	Rattus norvegicus

Alignment Length:	407	Identity:	94/407 - (23%)
Similarity:	125/407 - (30%)	Gaps:	142/407 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1686 KWYFDVDRNRCEEFQYGGCYGTNNRFDSLEQCQGTCAASE--NLPTCEQPVESGPCAGNFERWYY 1748
            ||..|....:.       |.||....  |:.||......:  |:....|||       ..:.|
  Rat    51 KWESDPSGTKT-------CIGTKEGI--LQYCQEVYPELQITNVVEANQPV-------TIQNW-- 97

  Fly  1749 DNETDICRPFTYGGCKGNKNNYPTEH-ACNYNCRQPGVLKDRCALP------------------- 1793
                  |:       :|.|......| ...|.|.....:.|...:|
  Rat    98 ------CK-------RGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLH 149

  Fly  1794 -----KQTGDCSEKLAKWH------------FSESEKRCVPF-------------------YYSG 1822
                 |:|  ||||....|            |...|..|.|.                   ::.|
  Rat   150 WHTVAKET--CSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDSIDSADAEEDDSDVWWGG 212

  Fly  1823 C------GGNKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGG 1881
            .      ||...   .:|..|:   .:|| |:.|..||..|          |.:|
  Rat   213 ADTDYADGGEDK---VVEVAEE---EEVA-DVEEEEAEDDE----------DVED---------- 250

  Fly  1882 CGGNENRFPTEESCLARCDRKPEPTTTTPATRPQPSR--QDVCDEEPAPGECSTWVLKWHFDRKI 1944
              |:|.....||......:|.....|||..|......  ::||.|:...|.|...:.:|:||...
  Rat   251 --GDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTE 313

  Fly  1945 GACRQFYYGNCGGNGNRFETENDCQQRC--LSQEPPAPTPPRAPAPTRQPDPAPTVAQCSQPADP 2007
            |.|..|:||.||||.|.|:||..|...|  :|.:....|... |.| :.|...||.|    .:.|
  Rat   314 GKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVSSQSLLKTTSE-PLP-QDPVKLPTTA----ASTP 372

  Fly  2008 GQCDKWALHWNYNETEG 2024
            ...||      |.||.|
  Rat   373 DAVDK------YLETPG 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443	9/34 (26%)
		Kunitz_BPTI	1729..1781	CDD:278443	9/52 (17%)
		Kunitz_BPTI	1789..1840	CDD:278443	17/111 (15%)
		Kunitz_BPTI	1848..1899	CDD:278443	10/50 (20%)
		KU	1920..1973	CDD:238057	23/54 (43%)
		Kunitz_BPTI	2001..2051	CDD:278443	7/24 (29%)
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
App	NP_062161.1	A4_EXTRA	24..188	CDD:128326	32/169 (19%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	28..123		20/102 (20%)
		Heparin-binding. /evidence=ECO:0000250\|UniProtKB:P05067	96..110		4/28 (14%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	131..189		10/59 (17%)
		Copper-binding. /evidence=ECO:0000250	135..155		0/19 (0%)
		Zinc-binding. /evidence=ECO:0000250	181..188		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..283		23/115 (20%)
		Kunitz_BPTI	294..341	CDD:333766	19/46 (41%)
		OX-2. /evidence=ECO:0000250\|UniProtKB:P05067	344..365		5/22 (23%)
		APP_E2	366..548	CDD:372388	9/28 (32%)
		Heparin-binding. /evidence=ECO:0000250	391..423
		Heparin-binding. /evidence=ECO:0000250	491..522
		Collagen-binding. /evidence=ECO:0000250\|UniProtKB:P05067	523..540
		Beta-APP	677..713	CDD:367525
		Interaction with PSEN1. /evidence=ECO:0000250\|UniProtKB:P05067	695..722
		APP_amyloid	716..766	CDD:371108
		Basolateral sorting signal. /evidence=ECO:0000250	724..734
		Interaction with G(o)-alpha	732..751
		Required for the interaction with KIF5B and for anterograde transport in axons. /evidence=ECO:0000250\|UniProtKB:P05067	756..770
		YENPXY motif, contains endocytosis signal. /evidence=ECO:0000250\|UniProtKB:P05067	757..762
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9558
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810