DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Thsd7a

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001178899.2 Gene:Thsd7a / 500032 RGDID:1566201 Length:1645 Species:Rattus norvegicus


Alignment Length:2240 Identity:415/2240 - (18%)
Similarity:605/2240 - (27%) Gaps:938/2240 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   400 WVEGEWSKC-SKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCP 463
            |..|.|.:| ...||..|.|.|::.|..  |.|..|:..:  |.:.|  :|:.:|.|   .|.|.
  Rat    50 WKTGPWGRCMGDDCGPGGIQTRAVWCAH--SEGWTTLHTN--CKQAV--RPSNQQNC---FKVCD 105

  Fly   464 ------KYHLGPWTPCDKLCG-------------DGKQTRKVTCFIEENGHKRVLPEEDCV---- 505
                  .:.||||..|..:..             :|.|.|::||..::    :.:|.||.:    
  Rat   106 WHKELYDWRLGPWNQCQPVISKSLEKARECVKGEEGIQVREITCIQKD----KDIPAEDIICEYF 166

  Fly   506 EEKPETEKSCLLTPCEGVDWIISQ---WSGCN-ACGQNTETRTAICGNKEGKVYPEEFCEPEVPT 566
            |.||..|::||: ||: .|.|:|:   ||.|: .||...:.||      ...|.|.:|.....|.
  Rat   167 EPKPLLEQACLI-PCQ-QDCIVSEFSSWSECSRTCGSGLQHRT------RHVVAPPQFGGSGCPN 223

  Fly   567 LS--RPCKSPKCEAQ--WFSSE---WSKCSAP--------------------CGKGVK------- 597
            |:  :.|:|..|||:  .:|.:   ||.||.|                    .||.||       
  Rat   224 LTEFQVCQSNPCEAEESMYSLQVGPWSACSVPHSRQARQARRRGKNKEREKERGKAVKDPEAREL 288

  Fly   598 -------------------------SRIVICGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEK 637
                                     :|.|:|....||:.    |.|.|.:|..|.:.|.|...::
  Rat   289 IKKKRNRNRQNRQENRYWDIQIGYQTRDVMCLNRTGKSA----DLSFCQQERLPMTFQSCVITKE 349

  Fly   638 VCPGEWFTGPWGKCSKPCGG-----GERVREVLCLSNGTKSVNCDEEKVEPL-SEKCNSEACTED 696
            ....||  ..|..|||.|..     |.|||        |:::     :..|: |||    .|.|.
  Rat   350 CQVSEW--SEWSPCSKTCHDVTSPTGTRVR--------TRTI-----RQFPIGSEK----ECPEL 395

  Fly   697 EILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAEDLMQSDSPT 761
            |             ::|.|...|     ||..       :....|...||.|....|.:.|..  
  Rat   396 E-------------EKEPCLSQG-----DGAV-------LCATYGWRTTEWTECHVDPLLSQQ-- 433

  Fly   762 PYDEFESTGTTFEGSGYDSE-----STTDSGISTEGSGDDEETSEASTDLSSSTDSGSTSSDSTS 821
              |:..:..|...|.|..:.     .|.|..:|...:..|:|                       
  Rat   434 --DKRRANQTALCGGGVQTREIYCIQTNDILLSHINTQKDKE----------------------- 473

  Fly   822 SDSSSSISSDATSEAPASSVSDSSDSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTG 886
                            ||...||...|.....||.:    ..|....|...|             
  Rat   474 ----------------ASKPVDSKLCTGPVPNTTQL----CHVPCPIECEVS------------- 505

  Fly   887 STNASDSTPESSTEASSSTDDSTDSSDNSSNVSESSTEASSSSVSDSNDSSDGSTDGVSSTTENS 951
                    |.|:..                                            ..|.||.
  Rat   506 --------PWSAWG--------------------------------------------PCTYENC 518

  Fly   952 SDSTSD---------ATSDSTASSDSTDSTSDQTTETTPESSTDSTESSTLDASSTTDASSTSES 1007
            :|....         .|::.|..|.:| .......|..|           .:..|..|..|....
  Rat   519 NDQQGKKGFKLRKRRITNEPTGGSGAT-GNCPHLLEAIP-----------CEEPSCYDWKSVRLG 571

  Fly  1008 SSESSTDGSSTTSNSASSETTGLSSDGSTTDATTAASDNTDITTDGSTDESTDGSSNASTEGSTE 1072
            ..|.. :|.:....:...|...::|||...|....                              
  Rat   572 DCEPD-NGKACGPGTQVQEVVCINSDGEEVDRQLC------------------------------ 605

  Fly  1073 GASEDTTISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSSDVTSDSTITDSSPSTEVSGSTD 1137
                              .|||.......:....:|...|..|        |.||.|...||.| 
  Rat   606 ------------------RDAIFPIPVACDAPCPKDCVLSAWS--------TWSSCSHTCSGKT- 643

  Fly  1138 SSSSTDGSSTDASSTEASSTDVTESTDSTVSGGTSDTTESGPTEESTTEGSTESTTEGSTDSTQS 1202
                |:|....|.|..|.:.:                           ||........:....:|
  Rat   644 ----TEGKQIRARSILAYAGE---------------------------EGGIRCPNSSALQEVRS 677

  Fly  1203 TDLDSTTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKC----KPKKSTCAKSEYGCCPDGKST 1263
            .:....|...|.|.......|.::..||::..|.:....|    :.:|..|.:...|        
  Rat   678 CNEHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWTGETSCSVGMQTRKVICVRVNVG-------- 734

  Fly  1264 PKGPFDEGCPIAKTCADTKYGCCLDGVSPAKGKNNKGCPKSQCAETLFGCCPDKFTAADGENDEG 1328
            ..||                               |.||:|...||:..|               
  Rat   735 QVGP-------------------------------KKCPESLRPETVRPC--------------- 753

  Fly  1329 CPETTTVPPTTTTEETQPETTTEIEGSGQDSTTSEPDTKKSC---SFSEFGCCPDAETSAKGPDF 1390
                 .:|                             .:|.|   .:|::..||.:         
  Rat   754 -----LLP-----------------------------CRKDCIMTPYSDWTPCPSS--------- 775

  Fly  1391 EGCGLASPVAKGCAESENGCCPDG------QTPASGPNGEGCSGCTRERFGCCPDSQTPAHGPNK 1449
                        |.|.::|.....      |.||.|  |..||....|...|  ::....|    
  Rat   776 ------------CREGDSGARKQSRQRVIIQLPAYG--GRECSDPLYEEKAC--EAPPTCH---- 820

  Fly  1450 EGCCLDTQFGCCPDNILAARGPNNEGCECHYTPYGCCPDNKSAATGYNQEGCACETTQYGCCPDK 1514
                             :.|...::...|...|:....|...|     ||||.         |.:
  Rat   821 -----------------SYRWKTHKWRRCQLVPWSIQQDVPGA-----QEGCG---------PGR 854

  Fly  1515 ----ITAAKGPKHEGCPCETTQFGCCPDGLTFAKGPHHHGCHCTQTEFKCCDDEKTPAKGPNGDG 1575
                ||..|....:....|..|:......||.|         |   :..|.||            
  Rat   855 QARAITCRKQDGGQASIQECLQYAGPVPALTQA---------C---QIPCQDD------------ 895

  Fly  1576 CTCVE-SKFGCCPDGVTKATDEKFGGCENVQEPPQKACGLPKETGTCNNYSVKYYFDTSYGGCAR 1639
            |.... |||..|.           |.|..|:...:...|..|:...|.|..:....:|.|     
  Rat   896 CQFTSWSKFSSCN-----------GDCGAVRTRKRAIVGKSKKKEKCKNSHLYPLIETQY----- 944

  Fly  1640 FWYGGCDGNDNRFESEAECKDTCQDYTGKHV-----CLLPKSAGPCTGFTKKWYFDVDRNRCEE- 1698
                              |  .|..|..:.|     |:||:.........|   ...|...|.: 
  Rat   945 ------------------C--PCDKYNAQPVGNWSDCILPEGKAEVLLGVK---VQGDNKECGQG 986

  Fly  1699 --FQYGGCYGTNNRFDSLEQCQ--------------GTCAASE--NLPTC--------------- 1730
              :|...||..|.|.....:|.              ..|..||  |...|               
  Rat   987 YRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKSCGSGVKVRSKWL 1051

  Fly  1731 -EQPVESG------------------PCAGNFERWYYDNET-DICRPFTYGG------------- 1762
             |:|...|                  ||..:..::.:..|. .:|: .|:..             
  Rat  1052 REKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYIWVTEPWSVCK-VTFVDMRDNCGEGVQTRK 1115

  Fly  1763 --CKGNKNNYPTEHACNYNCRQPGV-LKDR-CALPKQTGDCSEK--LAKW-HFSESEKRCVPFYY 1820
              |..|..:.|:||..:|.|....: |..| |.||     |.|.  :::| .:::....|.|   
  Rat  1116 VRCMQNTADGPSEHVEDYLCDPEDMPLGSRECKLP-----CPEDCVISEWGPWTQCSLPCNP--- 1172

  Fly  1821 SGCGGNKNNFPTLESCEDH---CPRQVAKDICEIPAEVGECANY---VTSWYYDTQDQACRQFYY 1879
              .|..:.:...:....|.   ||..|.|:.|.:..   .|..|   ||.|      ..|:....
  Rat  1173 --SGSRQRSADPIRQPADEGRACPDAVEKEPCNLNK---NCYRYDYNVTDW------STCQLSEK 1226

  Fly  1880 GGCG--------------------------GNENRFPTEESCLARCDRKPEPTTTTPATRPQPSR 1918
            ..||                          |.|..:....||...|                   
  Rat  1227 AVCGNGIKTRMLDCVRSDGKSVDLKYCEELGLEKNWQMNSSCTVEC------------------- 1272

  Fly  1919 QDVCDEEPAPGECSTWVLKWHFDRKIGACRQFYYGNCGGNGNRFETENDCQQRCLSQEPPAPTPP 1983
                   |...:.|.| ..|      ..|.|    .||..|...      ::|.::|  |.....
  Rat  1273 -------PLNCQLSDW-SPW------SECSQ----TCGLTGKMI------RRRTVTQ--PFQGDG 1311

  Fly  1984 RAPAPTRQPDPAPTVAQCSQPADPGQCDKWAL-HWNYNET-EGRC---------QSFYYGGCGGN 2037
            |         |.|::.:.|:|.....|.:|.. .|:..:. |.:|         ......|...:
  Rat  1312 R---------PCPSLMEQSKPCPVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADD 1367

  Fly  2038 DNRFATEEECSARCSVNIDIRIGADP----VEHDTSKCFLAFEPGNCY-NNVTRWFYNSAEGLCD 2097
            .::...||.|:     ||::.|..:.    .|..|..|     ||:|| |:.:.|  :..:..|.
  Rat  1368 FSKAVDEEFCA-----NIELIIDGNKQIVLEETCTQPC-----PGDCYLNDWSSW--SLCQLTCV 1420

  Fly  2098 EFVYTGCGG-NANNYAT---EEECQNECND--AQTTCALPPVRGRCSDLSRRWYFDERSGECHEF 2156
            .....|.|| ...:.|.   |.|.|:.|.:  .:|.        .|.|           |:|:|:
  Rat  1421 NGEDLGFGGIQVRSRAVIIQELENQHLCPEQILETK--------SCDD-----------GQCYEY 1466

  Fly  2157 EF--TGCRG-NRNNFVSQSDCLNFCIGEPVVEPSAPTYSVCAEPPEAGECDNRTTAWFYDSENMA 2218
            ::  :..:| :|..:..:||.:|...|..||  |.|.......||    |....:   |.||..|
  Rat  1467 KWMASAWKGSSRTVWCQRSDGVNVTGGCLVV--SQPDADRSCNPP----CSQPHS---YCSEMKA 1522

  Fly  2219 CTAFT-YTGCGGNGNRFETRDQCERQCGEFKGVDVCNEPVTTGPCTDWQTKYYFNTASQACEPFT 2282
            |.... ||....:.:   |.:||..            .||...|..:.:.....:.|....:|  
  Rat  1523 CRCEEGYTEVMSSNS---TLEQCTL------------IPVVVIPTVEDKRDVKTSRAVHPTQP-- 1570

  Fly  2283 YGGCDGTGNRFSDLFECQTVCLAGREPRVGSAKEICLLPVATGRC-----NGPSVHERRWYYDDE 2342
                  :.|                             |...||.     .||....:.|.|...
  Rat  1571 ------SSN-----------------------------PAGRGRTWFLQPFGPDGRLKTWVYGVA 1600

  Fly  2343 AGN------CVSFIYAGC------SGNQNN 2360
            ||.      .||.||..|      ...|||
  Rat  1601 AGAFVLLVFIVSMIYLACKKPKKPQRRQNN 1630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559 19/69 (28%)
TSP_1 645..693 CDD:278517 14/53 (26%)
Kunitz_BPTI 1611..1663 CDD:278443 7/51 (14%)
Kunitz_BPTI 1670..1721 CDD:278443 13/72 (18%)
Kunitz_BPTI 1729..1781 CDD:278443 15/101 (15%)
Kunitz_BPTI 1789..1840 CDD:278443 11/57 (19%)
Kunitz_BPTI 1848..1899 CDD:278443 13/79 (16%)
KU 1920..1973 CDD:238057 10/52 (19%)
Kunitz_BPTI 2001..2051 CDD:278443 11/60 (18%)
KU 2071..2121 CDD:238057 15/54 (28%)
Kunitz_BPTI 2127..2178 CDD:278443 10/53 (19%)
KU 2192..2245 CDD:238057 13/53 (25%)
KU 2251..2304 CDD:238057 6/52 (12%)
KU 2316..2372 CDD:238057 17/62 (27%)
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
Thsd7aNP_001178899.2 TSP1_spondin 184..235 CDD:408798 16/56 (29%)
TSP1_spondin 350..401 CDD:408798 20/82 (24%)
TSP1_spondin 624..683 CDD:408798 17/98 (17%)
TSP1_ADAMTS 688..757 CDD:408800 20/156 (13%)
TSP1_spondin 1025..>1065 CDD:408798 8/39 (21%)
TSP1_ADAMTS 1088..1151 CDD:408800 15/68 (22%)
TSP1_spondin 1155..1206 CDD:408798 10/55 (18%)
TSP1_spondin 1276..1329 CDD:408798 16/80 (20%)
TSP1_spondin 1404..1463 CDD:408798 17/79 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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