DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ppn and app

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001005698.1 Gene:app / 448208 XenbaseID:XB-GENE-479154 Length:750 Species:Xenopus tropicalis


Alignment Length:373 Identity:86/373 - (23%)
Similarity:118/373 - (31%) Gaps:96/373 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1686 KWYFDVDRNRCEEFQYGGCYGTNNRFDSLEQCQGTCAASE--NLPTCEQPVESGPCAGNFERWYY 1748
            ||..||...:       ||.||....  |:.||......:  |:....|||       ..:.|  
 Frog    50 KWETDVSGTK-------GCIGTKEGI--LQYCQDVYPELQITNVVEANQPV-------TIQNW-- 96

  Fly  1749 DNETDICRPFTYGGCKGNKNNYPTEH-ACNYNC------RQPGVLKDRCA-LPKQTGDCSEKLAK 1805
                  |:       :|.|......| ...|.|      ....::.|:|. |.::..|..|....
 Frog    97 ------CK-------RGRKQCKSRTHIVVPYRCLVGEFVSDALLVPDKCKFLHQERMDICETHLH 148

  Fly  1806 WHF----SESEKRCVPFYYS---GCGGNKNN------FPTLESCE-------------------- 1837
            ||.    |.|||......|.   .||.:|..      .||.:..|                    
 Frog   149 WHTVAKESCSEKSMSLHEYGMLLPCGIDKFRGVEFVCCPTADESESFDSADAEDDSDVWWGGADA 213

  Fly  1838 DHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGNENRFPTEESCLARCDRK 1902
            |:..|...|.:...|.|..|..........|.:|.           |:|.....||......:|.
 Frog   214 DYIDRSDDKAVEAQPEEEEEVVEVEEEEADDDEDD-----------GDEAEEEPEEPYEEATERT 267

  Fly  1903 PEPTTTTPATRPQPSR--QDVCDEEPAPGECSTWVLKWHFDRKIGACRQFYYGNCGGNGNRFETE 1965
            ....|||..|......  ::||.|:...|.|...:.:|::|.....|.||.||.||||.|.|::|
 Frog   268 TSIATTTTTTTESVEEVVREVCSEQAETGPCRAMIPRWYYDVTERKCAQFIYGGCGGNRNNFDSE 332

  Fly  1966 NDCQQRCLSQEPPAPTPPRAPAPTRQPDPAPTVAQCSQPADPGQCDKW 2013
            :.|...|.|...||         |....|.........|.|..:.|::
 Frog   333 DYCMAVCGSVTVPA---------TAASTPDAVDKYLENPNDENEHDRF 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443 11/34 (32%)
Kunitz_BPTI 1729..1781 CDD:278443 10/58 (17%)
Kunitz_BPTI 1789..1840 CDD:278443 18/84 (21%)
Kunitz_BPTI 1848..1899 CDD:278443 9/50 (18%)
KU 1920..1973 CDD:238057 20/52 (38%)
Kunitz_BPTI 2001..2051 CDD:278443 3/13 (23%)
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
appNP_001005698.1 A4_EXTRA 23..187 CDD:128326 37/167 (22%)
Kunitz_BPTI 292..339 CDD:333766 17/46 (37%)
APP_E2 346..528 CDD:372388 6/35 (17%)
Beta-APP 657..693 CDD:367525
APP_amyloid 696..746 CDD:371108
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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