DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and axo

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001246631.1	Gene:	axo / 43923	FlyBaseID:	FBgn0262870	Length:	2179	Species:	Drosophila melanogaster

Alignment Length:	1241	Identity:	238/1241 - (19%)
Similarity:	369/1241 - (29%)	Gaps:	468/1241 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1821 SGCGG-------NKNNFPTLESCEDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFY 1878
            ||.||       :.||...::..:.:   |..|  |..|.:.|.|..|:..|.|:.....|..|.
  Fly    89 SGTGGGGSNSGISGNNSAMIQGQKSN---QYEK--CAGPGDPGPCKQYIYKWRYEPTTNECTNFI 148

  Fly  1879 YGGCGGN-ENRFPTEESCLARCDRKPEPTTTTPATRPQPSRQDVCDEEPAPGECSTWVLKWHFDR 1942
            :|||.|| :|||.||..||..|...|.   |.|......:|      ||:..| |:.:|...:.:
  Fly   149 WGGCEGNPQNRFGTEAECLFHCIGGPH---TLPPFLQSTTR------EPSTTE-SSMLLGLPYTQ 203

  Fly  1943 KIGACRQFYYGNCGGNGNRFETENDCQQRCLSQEPPAPTPPRAPAPTRQPDPAPTVAQCSQPADP 2007
            ..........|..||:|.                        .|.|..|..|..|.|:..|
  Fly   204 SPAQSPDGMGGAEGGDGT------------------------TPVPIEQRGPELTFAETGQ---- 240

  Fly  2008 GQCDKWALHWNYNETEGR-CQSFYYGGCGGNDNRFATEEECSARCSVNI--DIRIGADP------ 2063
            |:...:|.:..:.:.:|. .|:|....|.....:|.|..........|:  ..||..||
  Fly   241 GKTFIFAKNNTFIQMDGDIIQTFQLRLCREISFQFRTRLPHGLLVYHNVKNPDRINLDPYALYVI 305

  Fly  2064 VEHDTSKCFLAFEPGNCYNNVT--------RWFY-----------------NSAE-----GLCDE 2098
            ||....|....|  |....:||        .|..                 ||.|     ||..|
  Fly   306 VEKGQLKVVHVF--GKHSTSVTVGESLNRDEWHSVMVRIDVHGARLIARVDNSQEEVYLKGLNHE 368

  Fly  2099 FVYTGCGGNANNYATEEECQNECNDAQTTCALPP---VRGRCSD--LSRRWYFDERSGECHEFEF 2158
            :.|    |.:.|                   ||.   |.|..|:  |....|..|        .|
  Fly   369 YNY----GVSTN-------------------LPSVVLVGGLSSEEKLHGVKYITE--------SF 402

  Fly  2159 TGCRGNRNNFVSQ----SDCLNFCIGEPVVEPSAPTYSVCAEPPEAGECDNRTTAWFYDSENMAC 2219
            .||  .||..:|.    ||.|          |.||                 ..|..:::.|..|
  Fly   403 VGC--IRNVVLSSGKAASDLL----------PIAP-----------------LVATKHENVNEGC 438

  Fly  2220 TAFTYTGCGGNGNRFETRDQCERQ---CGEFKGVDVCNEPVTTGPCTDWQTKYYFNTASQACEPF 2281
            :                 |.||.:   |  |.|....|.
  Fly   439 S-----------------DMCESRHNLC--FVGSRCINH-------------------------- 458

  Fly  2282 TYGG--CDGTGNRFS----DLFECQTVCLAGR----------EPRV-GSAKEICLLPVATGRCNG 2329
             |||  ||..|..:.    |::....:.|.|.          :.|| .|.:.|.|:
  Fly   459 -YGGISCDCFGTHYEGEHCDIYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLM--------- 513

  Fly  2330 PSVHERRWYYDDEAGNCVSFIYAGCSGNQNNFRSFEACTNQCRPEPNKQDNEIGQNPCDTFDAEC 2394
                 .|..:||.|     ..||  ||.....:...|   ..:.:....:.:.|.|...|...:
  Fly   514 -----FRTNFDDSA-----LFYA--SGESLKHQYIAA---SIKNQSVHVEMDFGDNVMSTVLTD- 562

  Fly  2395 QELRCPYGVRRVAARSQPECTQCICENPCEGYSCPEGQQCAIDV--ASSDDRQFAPVCRDIYKPG 2457
             :|...|.........|...:..:           :.||..:::  .:|.:..|.|   :||..|
  Fly   563 -DLTRGYWHNLTILHEQRTVSIIL-----------DQQQKVLELPATASGNMLFDP---EIYFGG 612

  Fly  2458 ECPALSANASGCARE----------CYTDADC-----RGDNKCCSDGCGQLCVHPARPTQPPRTQ 2507
            . |.|. ...|.|..          .|.|...     ||:
  Fly   613 G-PELH-KKKGLASHNNFVGSLKYVYYNDISILYELQRGN------------------------- 650

  Fly  2508 APVVSYPGDARAALEPKEAHELDVQTAIGGIAVLRCFATGNPAPNITWSLK-----NLVINTNKG 2567
             |.|.|.|...|..         |:..:..|.:...|||.    :|.|.:.     |:..:....
  Fly   651 -PKVHYHGVLEAEF---------VENEVNVIPITYPFATS----HIWWPINHAEEFNIKFDFRSS 701

  Fly  2568 R-YVLTANGDLT------IVQVRQTDDGTYVCVASNGLGEPVRREVALQVTEPVSQPAYIYGDKN 2625
            | ..:.|..|:|      ..::|.|.|                 :::..:...|        :.|
  Fly   702 RPGAVLAYSDVTTSAGNGFWEIRLTSD-----------------KLSFDLVPDV--------NNN 741

  Fly  2626 VTQ--IVELNRPAVIRCPAGGFPEPHVSW-----------------WRN--GQMFGLKNNLMARD 2669
            ||.  .:::||.              .||                 :|:  .||:||..|:  .|
  Fly   742 VTHSTTIKINRA--------------TSWHSVELDYKLGEIRFTVDYRHTLSQMYGLTFNI--GD 790

  Fly  2670 YSLVFNSIQLSDLGLYTC--EVYNQRRPVSLRVTLKAVGPVRPLSPEEEQYMQYVLNPATRPVT- 2731
            ..::.:|::.:.:||..|  ::......:..|..:|....|..::.:...|    ::|..||.|
  Fly   791 KLIIGSSLKSAAMGLVGCIRDIEINGHLIEPRHVVKTERVVGEVALDNCNY----IDPCKRPNTC 851

  Fly  2732 ----------QRPSYPYRPTRPAYVPEPTVNVH-----------AVLALEPKNSY---TPGSTIV 2772
                      .|.:...:.|  .|:.:   |.|           |:|.....:.|   ..|:.:.
  Fly   852 EHGGKCFVKDDRVTCDCKHT--GYIGK---NCHFTKYRKTCEELALLGFTKSDVYLIDIDGNGVF 911

  Fly  2773 ----MSCSVQGYPEPNVTWIKDDVPLYNNER--------VQITYQ---PH---RLVLSDVTSADS 2819
                :.|..|.......|.::.::|...:.|        ..|.|:   ||   .|:...:.....
  Fly   912 PPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARESDFSFNIRYREFSPHMLQELISHSLYCTQY 976

  Fly  2820 GKYTC-RAS----NAYTYANGEANVSI-------QSVVP--VSPECVDNPYFANCKLIVKGRYCS 2870
            .||.| ||.    :|..:.:...|:::       :...|  |:..|||.....||. :.:.::.|
  Fly   977 IKYDCYRAQLELHSATWFTSSAKNLTVDFLGNVKRGACPCSVNKTCVDPNQSCNCD-VKENKWNS 1040

  Fly  2871 NPYYTQ 2876
            :..|.|
  Fly  1041 DEGYYQ 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443	6/25 (24%)
		Kunitz_BPTI	1848..1899	CDD:278443	21/51 (41%)
		KU	1920..1973	CDD:238057	9/52 (17%)
		Kunitz_BPTI	2001..2051	CDD:278443	9/50 (18%)
		KU	2071..2121	CDD:238057	14/79 (18%)
		Kunitz_BPTI	2127..2178	CDD:278443	17/59 (29%)
		KU	2192..2245	CDD:238057	6/55 (11%)
		KU	2251..2304	CDD:238057	8/58 (14%)
		KU	2316..2372	CDD:238057	11/55 (20%)
		WAP	2457..2497	CDD:278522	9/54 (17%)
		Ig	2521..2610	CDD:299845	15/100 (15%)
		IG_like	2530..2610	CDD:214653	15/91 (16%)
		IG_like	2627..2703	CDD:214653	17/98 (17%)
		Ig	2636..2701	CDD:143165	14/85 (16%)
		IG_like	2766..2841	CDD:214653	18/97 (19%)
		Ig	2768..2830	CDD:299845	16/84 (19%)
		PLAC	2851..2883	CDD:285849	8/26 (31%)
axo	NP_001246631.1	KU	119..171	CDD:238057	21/51 (41%)
		Laminin_G_2	275..411	CDD:280389	37/170 (22%)
		EGF_CA	433..476	CDD:238011	15/88 (17%)
		Laminin_G_2	514..640	CDD:280389	28/153 (18%)
		Laminin_G_2	698..817	CDD:280389	26/159 (16%)
		EGF_CA	842..878	CDD:238011	7/40 (18%)
		Laminin_G_2	1112..1240	CDD:280389
		EGF_CA	1256..1297	CDD:238011
		Laminin_G_2	1351..1503	CDD:280389
		LamG	1612..1733	CDD:304605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810