DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and otk2

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	263	Identity:	63/263 - (23%)
Similarity:	92/263 - (34%)	Gaps:	71/263 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2574 NGDLTIVQVRQTDDGTYVC--------VASNGLGEPVRREVALQVTEPVSQPAYIYGDKNVTQIV 2630
            :|.|....|..:|.|.|.|        .||:..|..:..|....|.:|.|        ||    :
  Fly   113 SGALQFTSVLASDAGQYQCQLVIDDSVAASSSSGVLLVIEQLKFVPQPTS--------KN----L 165

  Fly  2631 ELNRPAVIRCPAGGFPEPHVSWWRNGQMFGLKNNLMARDYSLVFNSIQLSDLGLYTCEVYNQRRP 2695
            ||...:.:.|.|.|.|.|.|.|.|..|: .|..|:..::.:|:||.:.....|.|||...|.:..
  Fly   166 ELGTLSKVHCKAQGTPAPQVKWMRETQL-PLPVNVTDQNGTLIFNQVSNEQRGQYTCIASNSQGQ 229

  Fly  2696 VSLRVTLKAVGPVRPLSPEEEQYMQYVLNPATRPVTQRPSYPYRPTRPAYVPEPTVNVHAVLALE 2760
            ::..|::.                          |...|.:...|..|..|.|
  Fly   230 ITATVSIN--------------------------VVVAPKFSVPPEGPIEVAE------------ 256

  Fly  2761 PKNSYTPGSTIVMSCSVQGYPEPNVTWIKDDVPLYNN----ERVQITYQPHRLVLSDVTSADSGK 2821
                   ..|.|:.|...|.|:|.:.|.||...|..|    ||..: .:...|.:.:|...|.|:
  Fly   257 -------AGTAVIHCQAIGEPKPTIQWDKDLTYLNENNTDPERFSL-MENGTLEIRNVRPEDEGR 313

  Fly  2822 YTC 2824
            |.|
  Fly   314 YGC 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559
		ADAM_spacer1	214..329	CDD:283607
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845	11/43 (26%)
		IG_like	2530..2610	CDD:214653	11/43 (26%)
		IG_like	2627..2703	CDD:214653	22/75 (29%)
		Ig	2636..2701	CDD:143165	19/64 (30%)
		IG_like	2766..2841	CDD:214653	19/63 (30%)
		Ig	2768..2830	CDD:299845	19/61 (31%)
		PLAC	2851..2883	CDD:285849
otk2	NP_612571.1	IG_like	41..132	CDD:214653	6/18 (33%)
		I-set	155..238	CDD:254352	27/121 (22%)
		IGc2	175..228	CDD:197706	19/53 (36%)
		IG_like	250..331	CDD:214653	22/87 (25%)
		IGc2	258..323	CDD:197706	19/60 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4475
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900