DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and APLP2

DIOPT Version :10

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001633.1 Gene:APLP2 / 334 HGNCID:598 Length:763 Species:Homo sapiens


Alignment Length:276 Identity:75/276 - (27%)
Similarity:106/276 - (38%) Gaps:60/276 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1715 EQCQGTCAASENLPTCEQPVESGPCAGNFERWYYDNETDICRP-----FTYG---GCKGNKNNYP 1771
            |:||  ....|.:..||          |.:.| :....:.|..     ::||   .| |....:.
Human   147 EKCQ--FFHKERMEVCE----------NHQHW-HTVVKEACLTQGMTLYSYGMLLPC-GVDQFHG 197

  Fly  1772 TEHACNYNCRQPGVLKDRCALPKQTGDCSEKLAKWHFSESEKRCVPFYYSGCGGNKNNFPTLESC 1836
            ||:.|   |.|..::.   ::.|:..:..|:..:   .|.|:.....|       |:.|||....
Human   198 TEYVC---CPQTKIIG---SVSKEEEEEDEEEEE---EEDEEEDYDVY-------KSEFPTEADL 246

  Fly  1837 EDHCPRQVAKDICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGNENRFPTEESCLARCDR 1901
            ||.....|.:|  :...|.||.......:||||         :.|...||.. |||.........
Human   247 EDFTEAAVDED--DEDEEEGEEVVEDRDYYYDT---------FKGDDYNEEN-PTEPGSDGTMSD 299

  Fly  1902 KPEPTTTTPATRPQPSRQDVCDEEPAPGECSTWVLKWHFDRKIGACRQFYYGNCGGNGNRFETEN 1966
            | |.|....|         ||.:|...|.|...:.:|:||...|.|.:|.||.||||.|.||:|:
Human   300 K-EITHDVKA---------VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESED 354

  Fly  1967 DCQQRCLSQEPPAPTP 1982
            .|...|.:..||.|.|
Human   355 YCMAVCKAMIPPTPLP 370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAMTS_CR_3 116..213 CDD:437068
ADAMTS_spacer1 222..329 CDD:461796
TSP1_ADAMTS 347..396 CDD:465950
TSP1_ADAMTS 400..457 CDD:465950
TSP1_ADAMTS 465..520 CDD:465950
TSP1_ADAMTS 580..632 CDD:465950
TSP1_ADAMTS 643..693 CDD:465950
MSCRAMM_ClfA <1049..1262 CDD:468110
Kunitz_papilin_lacunin-like 1612..1663 CDD:438681
Kunitz_BPTI 1670..1721 CDD:425421 3/5 (60%)
Kunitz-type 1730..1780 CDD:438633 12/57 (21%)
Kunitz_BPTI 1789..1840 CDD:425421 11/50 (22%)
Kunitz_papilin_mig6-like 1849..1899 CDD:438679 13/49 (27%)
Kunitz_papilin_mig6-like 1922..1972 CDD:438679 21/49 (43%)
Kunitz_papilin_mig6-like 2001..2051 CDD:438679
Kunitz-type 2071..2121 CDD:438633
Kunitz_BPTI 2127..2178 CDD:425421
Kunitz_BPTI 2193..2245 CDD:425421
Kunitz_BPTI 2252..2303 CDD:425421
Kunitz_BPTI 2317..2372 CDD:425421
WAP 2455..2497 CDD:459672
Ig 2530..2610 CDD:472250
Ig strand B 2539..2543 CDD:409353
Ig strand C 2552..2556 CDD:409353
Ig strand E 2576..2579 CDD:409353
Ig strand F 2589..2594 CDD:409353
Ig strand G 2603..2606 CDD:409353
IG_like 2627..2703 CDD:214653
Ig strand B 2636..2640 CDD:409353
Ig strand C 2649..2653 CDD:409353
Ig strand E 2670..2674 CDD:409353
Ig strand F 2684..2689 CDD:409353
Ig strand G 2697..2700 CDD:409353
I-set 2766..2845 CDD:400151
Ig strand B 2771..2775 CDD:409353
Ig strand C 2784..2788 CDD:409353
Ig strand F 2821..2826 CDD:409353
PLAC 2851..2883 CDD:462560
APLP2NP_001633.1 A4_EXTRA 42..204 CDD:128326 16/73 (22%)
GFLD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 46..139
CuBD subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01217 147..205 17/74 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..299 26/109 (24%)
Kunitz_ABPP-like 309..360 CDD:438650 22/50 (44%)
APP_E2 365..547 CDD:463752 4/6 (67%)
JMTM_APLP2 680..760 CDD:411992
Interaction with DAB2. /evidence=ECO:0000250 749..763
NPXY motif 750..755
Blue background indicates that the domain is not in the aligned region.

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