DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and APLP1

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001019978.1	Gene:	APLP1 / 333	HGNCID:	597	Length:	651	Species:	Homo sapiens

Alignment Length:	346	Identity:	71/346 - (20%)
Similarity:	116/346 - (33%)	Gaps:	91/346 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 QTRECLRRDDRGEAVCSGGSRRYF--------SCNTQDCPEEE--SDFRAQQCSRFDRQQFDGVF 134
            ::|.|||...|....|    |:.:        ...||..|.|.  ...|:..|:.        ..
Human    80 RSRRCLRDPQRVLEYC----RQMYPELQIARVEQATQAIPMERWCGGSRSGSCAH--------PH 132

  Fly   135 YEWVPYTNAPNP--CELNCMPKGERFYYRQR-EKVVDGTR--------CNDKDLDVCVNGECMPV 188
            ::.||:...|..  .|...:|:|.||.:::| ::....||        |:.:.|.:..:|..:|.
Human   133 HQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197

  Fly   189 GCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSSNY 253
            |.|...|   .|..|....|......|.....:|:...||..     .|||.:...||:
Human   198 GSDRFRG---VEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSR-----VEGAEDEEEEES------ 248

  Fly   254 LACRNHSGHYYLNGDWRIDFPRPM--FFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLV- 315
                               ||:|:  :|.       ..|.  |..::.|...|.|.:|.:|..|
Human   249 -------------------FPQPVDDYFV-------EPPQ--AEEEEETVPPPSSHTLAVVGKVT 285

  Fly   316 --QEKNISLDYEYSIPESLS------HSQQDTHTWTHHQFNACSASCG-GGSQSRKVTCNNRITL 371
              ......:|..:.:|..:|      .::.|.......|.|....... ..:||:.:...:|..|
Human   286 PTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQAL 350

  Fly   372 AEVNPSLCDQKSKPVEEQACG 392
            .|...|:.    :.:|||..|
Human   351 NEHFQSIL----QTLEEQVSG 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	9/38 (24%)
		ADAM_spacer1	214..329	CDD:283607	22/119 (18%)
		TSP1	468..521	CDD:214559
		TSP_1	645..693	CDD:278517
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
APLP1	NP_001019978.1	A4_EXTRA	46..211	CDD:128326	33/145 (23%)
		GFLD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	50..146		16/77 (21%)
		APP_N	55..154	CDD:280358	17/85 (20%)
		CuBD subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01217	154..212		15/60 (25%)
		APP_Cu_bd	156..211	CDD:289676	14/57 (25%)
		Copper-binding. /evidence=ECO:0000250	158..178		4/19 (21%)
		Zinc-binding	204..211		3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..287		22/111 (20%)
		APP_E2	285..467	CDD:289677	16/87 (18%)
		O-glycosylated at three sites	285..305		2/19 (11%)
		Heparin-binding. /evidence=ECO:0000250	310..342		5/31 (16%)
		Heparin-binding. /evidence=ECO:0000250	410..441
		Collagen-binding. /evidence=ECO:0000250	442..459
		APP_amyloid	597..648	CDD:287486
		Basolateral sorting signal. /evidence=ECO:0000250	605..616
		Interaction with DAB1. /evidence=ECO:0000250	633..650
		Interaction with DAB2. /evidence=ECO:0000250	637..651
		Clathrin-binding. /evidence=ECO:0000255	641..644
		NPXY motif, contains endocytosis signal	641..644
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900