DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and Adamts3

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_808540.2	Gene:	Adamts3 / 330119	MGIID:	3045353	Length:	1204	Species:	Mus musculus

Alignment Length:	861	Identity:	239/861 - (27%)
Similarity:	337/861 - (39%)	Gaps:	247/861 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDD-RGEAVCSGGSRRYFSCNTQDCPEEESD 116
            :||    |..|:....||||||.||.::||:|..... .|...|.|.:..|..|||::|.:...|
Mouse   551 DGN----WGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFED 611

  Fly   117 FRAQQC----SRFDRQQFDGVFYEWVP--YTNAPNPCELNCMPK--GERFYYRQREKVVDGTRCN 173
            ||||||    |.||   :....:.|:|  :.::...|.|.|..|  |:..|.:|  .|.|||||:
Mouse   612 FRAQQCQQRNSHFD---YQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQ--LVHDGTRCS 671

  Fly   174 DKD-LDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPG-YNDLLLLP 236
            .|| ..:||.|||:.||||..:||:..||||..||||.|.|:|::.|.|......| .....:||
Mouse   672 YKDPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRGAFVLP 736

  Fly   237 EGATNIRIEETVPSSNYLACRNH-SGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLT 300
            :||.||.:.||..:.|.||.:|. :|||.|||.......|........|:|..:.    ..:.|.
Mouse   737 KGARNISLAETRETKNVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIED----DIETLH 797

  Fly   301 CSGPISESLFIVMLVQEKNI--SLDYEYSIPE---------SLSHSQQDTHTWTHHQFNACSASC 354
            ..||:.:.:.::::.||.:.  ||.|:|.|.|         ::...:.||..|....::.||..|
Mouse   798 TDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSEPC 862

  Fly   355 GGGSQSRKVTCNNRITLAEVNPSLCD--QKSKPVEEQACGTEPCA-PHWVEGEWSKCSKGCGSDG 416
            |||.|..|..|..:.....|:.|.|:  :|.||: .:.|..:.|. |.|...||..||:.|||.|
Mouse   863 GGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPI-RRMCNIQECTHPVWAADEWEHCSRSCGSSG 926

  Fly   417 FQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCP-KYHLGPWTPCDKLCGDG 480
            .|.|::.|.:....|.:.......||   |::|.:::.|||  ..|| ::..|.|..|...||:|
Mouse   927 NQLRTVRCLQPLQDGTNRSVHSKYCL---GDRPESRRPCNR--VPCPAQWKTGSWNECSVTCGEG 986

  Fly   481 KQTRKVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEGVDWIISQWSGCNACGQNTETRTA 545
            .:.|:|.|   ..|       :.|..||||:.:.|.|.||                  |.|.
Mouse   987 TEVRQVLC---RTG-------DHCDGEKPESVRPCQLPPC------------------NDEP--- 1020

  Fly   546 IC-GNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEFDGK 609
             | |:|      ..||:.||  |:|.|..|
Mouse  1021 -CLGDK------SIFCQMEV--LARYCSIP----------------------------------- 1041

  Fly   610 TVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSV 674
                                    |..|:|
Mouse  1042 ------------------------GYNKLC----------------------------------- 1047

  Fly   675 NCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEEDCDEDGIELISDGLSDDEKSEDVIDL 739
             |         |.|:..:.|    ||     .|...:..:...|.|    .|.||..:|
Mouse  1048 -C---------ESCSKRSGT----LP-----PPYLQEAAEIHSDAI----FGPSDLPRS------ 1083

  Fly   740 EGTAKTETTPEAEDLMQSDSPTPYDEFESTGTTFEG---SGYDSESTTDSGISTEGSGDDEETSE 801
                          |:.   |||:.. .|:||..|.   |.:.|.:..::..:...|      |.
Mouse  1084 --------------LVM---PTPFLP-SSSGTRAEKKSLSSFSSMANPNADAAFRAS------SR 1124

  Fly   802 ASTDLSSSTDSGSTSSDSTSSDSSSSISSDATSEAPASSVSDS-----SDSTDASTET-TGVSDD 860
            ||.|........:......|..|||||.:|..  .|||.|:.:     |||..||.:| |...||
Mouse  1125 ASADFPRKRAHQAGRKTLESVPSSSSIKTDHL--RPASPVAAAPSPAISDSIGASPQTRTPKKDD 1187

  Fly   861 STDVS--SSTEASASE 874
            :..||  ..|.::|||
Mouse  1188 AKSVSRRHPTRSTASE 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	20/51 (39%)
		ADAM_spacer1	214..329	CDD:283607	34/118 (29%)
		TSP1	468..521	CDD:214559	18/52 (35%)
		TSP_1	645..693	CDD:278517	3/47 (6%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamts3	NP_808540.2	Pep_M12B_propep	66..200	CDD:279848
		ZnMc_ADAMTS_like	256..457	CDD:239801
		Reprolysin	258..460	CDD:279729
		TSP1	554..605	CDD:214559	20/50 (40%)
		ADAM_spacer1	713..828	CDD:283607	34/118 (29%)
		TSP1	914..968	CDD:214559	19/58 (33%)
		TSP1	971..1016	CDD:214559	17/54 (31%)
		PLAC	1024..1052	CDD:285849	14/139 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900