Protein Alignment Ppn and Adamtsl2

DIOPT Version :9

• Sequence 1: NP_788752.2
• Gene: Ppn / 43872
• FlyBaseID: FBgn0003137
• Length: 2898
• Species: Drosophila melanogaster
• Sequence 2: XP_038962070.1
• Gene: Adamtsl2 / 311827
• RGDID: 1305459
• Length: 957
• Species: Rattus norvegicus
• Alignment Length: 937
• Identity: 238/937 - (25%)
• Similarity: 353/937 - (37%)
• Gaps: 304/937 - (32%)

  Fly    44 PESSVTPGGEGNDP---DEWTPWSSPSDCSRTCGGGVSYQTRECLRRDDR-----GEAVCSGGSR 100
            |.|:...||.....   .|||.|::   |||:|||||:.|.|.||::..:     |...|.|.|:
  Rat    34 PTSNSLEGGADATAYWWGEWTKWTA---CSRSCGGGVTSQERHCLQQRRKSVPGAGNRTCVGTSK 95

  Fly   101 RYFSCNTQDCPEEESDFRAQQCSRFDRQQFDGVFYEWVP-----YTN-APNPCELNCMPKGERFY 159
            ||..|..|:||.:...||.:||..|:.:.:||..|:|.|     |.: :..||:|:|....
  Rat    96 RYQLCRVQECPPDGRSFREEQCVSFNSRVYDGRAYQWKPLYPDDYMHISSKPCDLHCTTVD---- 156

  Fly   160 YRQREKVV---DGTRCNDKDL-DVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTI 220
             .||:.:|   |||.|...|| .|||:|:|.|:|||.:|.|....|||..|.||||:|..:....
  Rat   157 -GQRQLMVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGVCQGDGSSCTHVTGNY 220

  Fly   221 TTKDLAPGYNDLLLLPEGATNIRIEETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWN 285
            ...|...||:.:..:|.||.:|:|.|...|::.||..:.:|.|:.||::::|.|:....|.:...
  Rat   221 RKGDNHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGFYFFNGNYKVDSPKNFNIAGTVVK 285

  Fly   286 YQRKPMGF--AAPDQLTCSGPISESLFIVMLVQE-KNISLDYE----------------YSIPES 331
            | |:||..  ...:.:...||.::.|.:::..|. |:.|:.:|                ||..|:
  Rat   286 Y-RRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQSPHMHHLPPVYYSFSEA 349

  Fly   332 LSHSQQDT--------------------------------------------------------- 339
            .|.|.:.|
  Rat   350 ASESTESTERQELDSARLLGFLQHNGSLYGQPSSERLGLNSQLFPPTAPEVELGPSRGQETNEVC 414

  Fly   340 --------------------------------------HTWTHHQFNA----------------- 349
                                                  |..:|...:|
  Rat   415 KQASGGVCEGPPRGKGFQDHNATGRALLGDKDDREISAHFTSHELLSANTISDQLLGTGSDSEEF 479

  Fly   350 ----------------------------------------------------------------- 349
                                                                             
  Rat   480 SLNETMNSIFAQGAPRSSPAESLYVDYEENEGPAAYLINGSYLELNSDRINTSSEAPFPNTSASL 544

  Fly   350 -------------------------------------CSASCGGGSQSRKVTCNNRITLAEVNPS 377
                                                 |||:|..|..|....| .|....||:.|
  Rat   545 PSLAGNRTHKARTRPKARKQGVSPADMYRWKLSSQEPCSATCTTGVMSAYAMC-VRYDGVEVDDS 608

  Fly   378 LCD--QKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSG-EHTVEEDA 439
            .||  .:.:||.|...|.| |.|.|....||:||:.|| :|.|.|.:.|.::.|.| :.:|..|
  Rat   609 YCDALTRPEPVHEFCAGRE-CQPRWETSSWSECSRTCG-EGHQFRIVRCWKMLSPGFDSSVYSD- 670

  Fly   440 VCLKEVGNKPATKQECNRDVKNC-PKYHLGPWTPCDKLCGD-GKQTRKVTCFIEENGHKRVLPEE 502
            :|......:|..::.|....  | |::.:..|:.|...||: ...||.:.|..:|    |:...
  Rat   671 LCEATEAVRPEERKTCRNPA--CGPQWEMSEWSECTAKCGERSVVTRDIRCSEDE----RLCDP- 728

  Fly   503 DCVEEKPETEKSCLLTPCEGVDWIISQWSGCN-ACGQNTETRTAICGNKEGKVYPEEFCEPEV-P 565
               ..:|..||:|...||:. .|.:|.|..|: :|||....|...|...:|:|.||..|:.|. |
  Rat   729 ---NTRPVGEKNCTGPPCDR-QWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQTETKP 789

  Fly   566 TLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVICGEF-DGKTVTPADDDSKCNKETKPESE 629
            ....||....|.|.|.:.:|.:|:..||:|||.|:|:|.|. :||  ......|:|....||..|
  Rat   790 LAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGK--PQMRSGSECGLARKPPEE 852

  Fly   630 QDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCLSNGTKSV-NCDEEKVEPLSEKCNSEAC 693
            ..|  .|:.| .:|:|.||.:|:|.||.|.|:|:|.|. .||..| .||     ||.:....:||
  Rat   853 STC--FERPC-FKWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCD-----PLVKPVGRQAC 908

  Fly   694 TEDEILPLTSTDKPIEDDEEDC-DEDG 719
               ::.|.     |.|..::.| |:.|
  Rat   909 ---DLQPC-----PTEPPDDSCQDQPG 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	23/55 (42%)
		ADAM_spacer1	214..329	CDD:283607	32/133 (24%)
		TSP1	468..521	CDD:214559	14/53 (26%)
		TSP_1	645..693	CDD:278517	19/48 (40%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamtsl2	XP_038962070.1	TSP1	50..106	CDD:214559	24/58 (41%)
		ADAM_spacer1	216..330	CDD:368694	30/114 (26%)
		TSP1_ADAMTS	632..691	CDD:408800	18/62 (29%)
		TSP1_ADAMTS	695..743	CDD:408800	13/55 (24%)
		TSP1_ADAMTS	747..800	CDD:408800	18/52 (35%)
		TSP1_ADAMTS	804..860	CDD:408800	21/59 (36%)
		TSP1_ADAMTS	863..913	CDD:408800	22/58 (38%)
		PLAC	922..953	CDD:400844	3/6 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810