DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and Adamtsl4

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	XP_038958286.1	Gene:	Adamtsl4 / 310670	RGDID:	1561012	Length:	1035	Species:	Rattus norvegicus

Alignment Length:	801	Identity:	246/801 - (30%)
Similarity:	352/801 - (43%)	Gaps:	155/801 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ASIHDSQSRFPGLRQKR----QYGANMYLPESSVT-----------PGGEGNDPDEWTP------ 62
            :|..||:| |.|..:.|    |.......|.|.||           ||.....||.|.|
  Rat   252 SSFRDSRS-FQGSPEPRMPTSQGAERQPHPFSPVTRSQLSRRHWRPPGSPHRSPDGWLPLTRDSS 315

  Fly    63 --WS--SPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCS 123
              ||  :||.           .|.|           |||.|.:..:|:.:.||.|:.|.||.||:
  Rat   316 PHWSLFAPSS-----------PTPE-----------CSGESEQMRACSQEPCPPEQPDPRALQCA 358

  Fly   124 RFDRQQFDGVFYEWVPYTNAPNP--CELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNGECM 186
            .||.|:|.|..|:|.|:|.....  |||||.|:|.|||.|..|||.|||.|....||:||.|.|:
  Rat   359 AFDSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPGSLDICVAGHCL 423

  Fly   187 PVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYNDLLLLPEGATNIRIEETVPSS 251
            ..|||.:|||..:.|.|..||||||||:.:...:|.:....||..:|.:|.||:::||.:..|||
  Rat   424 SPGCDGILGSGRRPDGCGVCGGDGSTCRLVSGNLTDRGGPLGYQKILWIPAGASHLRISQFRPSS 488

  Fly   252 NYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQLTCSGPISESLFIVMLVQ 316
            ||||.|...|...:||:|.:|.|.......:.:.|.|.|......:.|:..||.::.:.:.|:.|
  Rat   489 NYLALRGPGGRSIINGNWAVDPPGSYAAVGTVFQYNRPPREEGKGETLSAEGPTTQPVDVYMIFQ 553

  Fly   317 EKNISLDYEY---SIPES---------------------------------------LSHSQQDT 339
            |.|..:.|:|   :.|||                                       :......|
  Rat   554 EDNPGVFYQYVTSAAPESPSTMPPALQLQPEMLRGEPLLPSAPRPVRAPGTLQRQARIPQVPPPT 618

  Fly   340 HT----------WTHHQFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSK-PVEEQACGT 393
            |.          |.....:.||||||.|.......|.:|.:..|::...|...:: |...::|..
  Rat   619 HVRTAMGSSAGYWKQVGHSECSASCGKGVWRPIFLCVSRESGEELDEQSCAVGARPPASPESCHR 683

  Fly   394 EPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGN--KPATKQECN 456
            .||.|:|..|||:.||:.|| .|.|:|.:.|.:....|..:|..:     ..|:  :|...|.|
  Rat   684 PPCPPYWEAGEWTSCSRSCG-PGTQHRQLLCRQEFGGGGSSVPPE-----RCGHLPRPNITQSC- 741

  Fly   457 RDVKNCPKYHL-GPWTPCDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVE--EKPETEKSCLLT 518
             .::.|..:.: .||:.|...||.|:::|:|.| :..|||:  :.:::|..  ..|.:.::|.:.
  Rat   742 -QLRLCGHWEISSPWSQCSVRCGRGQRSRQVRC-VGSNGHE--VGKQECASGPPPPPSREACDMG 802

  Fly   519 PCEGVDWIISQWSG-CNA-CGQNTETRTAIC--------GNKE-GKVYPEEFCEPEVPTLSRP-- 570
            ||. ..|..|.||. |:| ||...:.|..:|        |:.| |..  |:.|    |..|||
  Rat   803 PCT-TAWFYSDWSSKCSAECGTGIQRRAVVCLRSGETLQGDPEAGST--EQGC----PLRSRPPD 860

  Fly   571 ---CKSPKCEA--QWFSSEWSKCSAPCGKGVKSRIVICGEFDGKTVTPADDDSKCNKETKPESEQ 630
               |....||.  :|::..||:||:.||.|.:.|.:||....| |.......|.|:...:|.:.|
  Rat   861 MRACSLGPCEKTWRWYTGPWSECSSECGSGTQHRDIICVSKLG-TKFNVTSPSNCSHLPRPPALQ 924

  Fly   631 DCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREVLCL-SNGTKSVNCDEEKVEPLSEKCNSEACT 694
            .|:|:  .|..:||:..|..||:.|.||.:.|||.|| ||.|.|..|...........|||:.|.
  Rat   925 PCQGQ--ACEDQWFSTLWSPCSQSCQGGVQTREVQCLSSNHTLSSRCPPHLRPSRKRPCNSQPCN 987

  Fly   695 EDEILPLTSTDKPIEDDEEDC 715
            :       ..|...:|....|
  Rat   988 Q-------RPDDQCKDSSPHC 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	13/60 (22%)
		ADAM_spacer1	214..329	CDD:283607	35/117 (30%)
		TSP1	468..521	CDD:214559	16/54 (30%)
		TSP_1	645..693	CDD:278517	19/48 (40%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamtsl4	XP_038958286.1	PHA03247	<24..358	CDD:223021	36/128 (28%)
		ADAM_spacer1	451..564	CDD:368694	34/112 (30%)
		TSP1_ADAMTS	637..686	CDD:408800	13/48 (27%)
		TSP1_ADAMTS	690..746	CDD:408800	18/63 (29%)
		TSP1_ADAMTS	754..804	CDD:408800	15/52 (29%)
		TSP1_ADAMTS	808..869	CDD:408800	20/66 (30%)
		TSP1_ADAMTS	875..931	CDD:408800	19/58 (33%)
		TSP1_ADAMTS	935..986	CDD:408800	21/50 (42%)
		PLAC	994..1023	CDD:400844	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810