DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Appl

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001245448.1 Gene:Appl / 31002 FlyBaseID:FBgn0000108 Length:890 Species:Drosophila melanogaster


Alignment Length:294 Identity:72/294 - (24%)
Similarity:116/294 - (39%) Gaps:75/294 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   654 PCGGGERVREVLCLSNGTKSVNCDEE-KVEPLSEKCNSEACTEDEILPL----TSTDKPIEDDEE 713
            |||        :.:.:|.:.|.|.:. |.:.:..|     .|:..::|.    ::.|:.:.:||:
  Fly   183 PCG--------ISVFSGVEFVCCPKHFKTDEIHVK-----KTDLPVMPAAQINSANDELVMNDED 234

  Fly   714 ---------DCDEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAEDLMQSDSPTPYDEFEST 769
                     |.:||.::...|.:.|||:.:.|.|...||             ..||..    .|:
  Fly   235 DSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVADEAATA-------------GGSPNT----GSS 282

  Fly   770 GTTFEGSGYDSESTTDSGISTEGSGDDEETSEASTDLSSSTD-SGSTSSDSTSSDSSSSIS---S 830
            |.:..||..|..:..|||...:...:|...||:..::.:|.| ||.....|..|||||..|   :
  Fly   283 GDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVSLKSDSSSPSSAPVA 347

  Fly   831 DATSEAPASSVSDSSDSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTNASDSTP 895
            .|..:||..|.|                     |:|:.:.|||.:..|:..|.::| |.|  ..|
  Fly   348 PAPEKAPVKSES---------------------VTSTPQLSASAAAFVAANSGNSG-TGA--GAP 388

  Fly   896 ESSTEASSS---TDDSTDSSDNSSNVSESSTEAS 926
            .|:.:.:|.   |.........|..||:...|.|
  Fly   389 PSTAQPTSDPYFTHFDPHYEHQSYKVSQKRLEES 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559
TSP_1 645..693 CDD:278517 8/39 (21%)
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057
WAP 2457..2497 CDD:278522
Ig 2521..2610 CDD:299845
IG_like 2530..2610 CDD:214653
IG_like 2627..2703 CDD:214653
Ig 2636..2701 CDD:143165
IG_like 2766..2841 CDD:214653
Ig 2768..2830 CDD:299845
PLAC 2851..2883 CDD:285849
ApplNP_001245448.1 A4_EXTRA 26..198 CDD:128326 5/22 (23%)
APP_N 33..141 CDD:280358
APP_Cu_bd 143..198 CDD:289676 5/22 (23%)
APP_E2 387..580 CDD:289677 9/36 (25%)
GBP_C <629..682 CDD:303769
APP_amyloid 834..887 CDD:287486
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4295
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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