DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppn and Adamts14

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001376166.1	Gene:	Adamts14 / 309837	RGDID:	1308899	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	803	Identity:	213/803 - (26%)
Similarity:	307/803 - (38%)	Gaps:	193/803 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PESSVTPGGEGNDPDEWTPWSSPSDCSRTCGGGVSYQTRECLRRDD----RGEAVCSGGSRRYFS 104
            ||.  |.|.:|.    |:.|::...|||:|||||..::|.|   |:    .|..:|||....|..
  Rat   529 PEQ--TYGQDGG----WSSWTNFGSCSRSCGGGVRSRSRSC---DNPPPAYGGRLCSGPMFEYQI 584

  Fly   105 CNTQDCPEEESDFRAQQCSRFDRQQF---DGVFYEWVPY--TNAPNPCELNCMPKGERFYYRQRE 164
            ||::|||....|||||||::  |..:   ....:.|:||  .:....|||.|............:
  Rat   585 CNSEDCPGPFEDFRAQQCAK--RNSYYTHQDAKHSWLPYEPDSEAQKCELICQSADTGDVVFMNQ 647

  Fly   165 KVVDGTRCNDKD-LDVCVNGECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPG 228
            .|.|||||:.:| ..||..|||:|.|||..:||...:|||..||||.|.|:|::.|:........
  Rat   648 VVHDGTRCSYRDPYSVCARGECVPFGCDKEVGSMKTDDKCGVCGGDNSHCRTVKGTLGKASKQAA 712

  Fly   229 YNDLLLLPEGATNIRIEETVPSSNYLACRNH-SGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMG 292
            ....:.:|.||.:|:||....:...:|.:|. :|.:.||...:....|........|.:..:.
  Rat   713 ALKQVQIPAGARHIQIELLEKAPRRIAVKNQVTGSFILNPKGKEASSRTFTALGLEWEHAAED-- 775

  Fly   293 FAAPDQLTCSGPISESLFIVMLVQEKNI---SLDYEYSIPESL-----SHS----QQDTHTWTHH 345
              ..|.|..:||:.|::.:::|...:..   ||.|:|.|.|.|     |::    :.|::.|...
  Rat   776 --TKDSLKTNGPLPEAIAVLVLPPAEGKPRGSLAYKYVIHEDLLPLIGSNNVLLEEMDSYEWALK 838

  Fly   346 QFNACSASCGGGSQSRKVTCNNRITLAEVNPSLCDQKSKP-VEEQACGTEPC-APHWVEGEWSKC 408
            .::.||.:||||.|..|..|.:|.....|...|||.|.:| ...:.|...|| .|.||..||..|
  Rat   839 SWSPCSKACGGGIQFTKYGCRHRRDHHMVQRHLCDHKKRPKAIRRRCNQHPCPQPTWVTEEWGAC 903

  Fly   409 SKGCGSDGFQNRSITCERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCP-KYHLGPWTP 472
            |:.||..|.|.|.:.|....|:|.|.......||   ||:|..|:.|.|  ..|| ::..|.|:.
  Rat   904 SRSCGKLGLQTRGVQCLLPLSNGTHKAMPAKACL---GNRPEAKRPCLR--VPCPAQWRTGAWSQ 963

  Fly   473 CDKLCGDGKQTRKVTCFIEENGHKRVLPEEDCVEEKPETEKSCLLTPCEGVDWIISQWSGCNACG 537
            |...||.|.|.|:|.|                      ...|..|.|||||.
  Rat   964 CSATCGKGIQQRQVVC----------------------RNSSSALGPCEGVK------------- 993

  Fly   538 QNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGVKSRIVI 602
                                       |...|.|..|.|.
  Rat   994 ---------------------------PDTVRICSQPACG------------------------- 1006

  Fly   603 CGEFDGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCSKPCGGGERVREV-LC 666
             |:....||.....|        |.::.               |||...|:|.....|:..: .|
  Rat  1007 -GDLQNSTVNAEVQD--------PVTKM---------------GPWEPQSRPLTPMNRISTMEPC 1047

  Fly   667 LSNGTKSVNCDEEKVEPLSEKCN--------SEACTED--------EILPLTSTDKPIEDDEEDC 715
            :  |.:||.|   ::|.|...|.        .|:|.:.        ..||..||...:..:....
  Rat  1048 V--GDRSVFC---RMEVLDRYCTIPGYLRLCCESCIKKASSSNASLASLPTFSTPGSLLPEPTAT 1107

  Fly   716 DEDGIELISDGLSDDEKSEDVIDLEG-----TAKTE--TTPE--AEDLMQSDSPT-----PYDEF 766
            .||..........:|.:......|.|     ::.|:  .||:  :....:|:||.     |:...
  Rat  1108 QEDMESTRGPTRLEDHRQSQPTQLSGAVDRISSVTQHLVTPQMLSPKASESNSPATPQGPPWGRT 1172

  Fly   767 ESTGTTFEGSGYDSESTTDSGIS 789
            ::...|.||.|...|....||.|
  Rat  1173 QTAVPTSEGQGQSREEPGHSGTS 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	21/54 (39%)
		ADAM_spacer1	214..329	CDD:283607	25/118 (21%)
		TSP1	468..521	CDD:214559	13/52 (25%)
		TSP_1	645..693	CDD:278517	15/56 (27%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamts14	NP_001376166.1	Pep_M12B_propep	68..191	CDD:396235
		ZnMc_ADAMTS_like	243..441	CDD:239801
		ADAM_CR_2	456..525	CDD:407643
		TSP1	539..591	CDD:214559	21/54 (39%)
		ADAM_spacer1	698..813	CDD:368694	25/118 (21%)
		TSP1_ADAMTS	835..890	CDD:408800	18/54 (33%)
		TSP1_ADAMTS	895..952	CDD:408800	23/61 (38%)
		TSP1_ADAMTS	956..1005	CDD:408800	21/110 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000