DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ppn and Adamtsl3

DIOPT Version :9

Sequence 1:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster
Sequence 2:	NP_001101003.2	Gene:	Adamtsl3 / 308787	RGDID:	1305155	Length:	1705	Species:	Rattus norvegicus

Alignment Length:	1903	Identity:	420/1903 - (22%)
Similarity:	616/1903 - (32%)	Gaps:	587/1903 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FIVLASIHDSQSRFPGLRQKRQYGANMYLPESSVTPGGE-----------------------GND 56
            |.|...:..:..:.||.         .:|||.:::|.|.                       .:|
  Rat    28 FTVSGLLQATAEKSPGA---------YFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNAHSD 83

  Fly    57 PDE---WTPWSSPSDCSRTCGGGVSYQTRECLRRDDRGEAVCSGGSRRYFSCNTQDCPEEESDFR 118
            .|:   |..|...||||||||||.||..|.||...:     |.|.:.||.:|:..|||.:..|||
  Rat    84 EDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRN-----CEGQNIRYKTCSNHDCPADAEDFR 143

  Fly   119 AQQCSRFDRQQFDGVFYEWVPYTNAP-NPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVN 182
            |||||.::..|:.|.:|||:|..|.| .||.|.|..:|:........||:||||||...||:|::
  Rat   144 AQQCSAYNDVQYQGHYYEWIPLHNDPAAPCALKCHARGQSLVVELAPKVLDGTRCNADTLDMCIS 208

  Fly   183 GECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYND--LLLLPEGATNIRIE 245
            |.|..||||..|||.||:|.|..|.||||||:.:|.. |...|:|...:  ::.:|.|:.::||.
  Rat   209 GICQTVGCDRQLGSSAKKDNCGVCAGDGSTCRLVRGQ-TKVHLSPEKKEENVIAVPLGSRSVRIT 272

  Fly   246 ETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQR---------------------- 288
            ...|:..::..:...|.   .|:...:.|......|:...:|:
  Rat   273 VKGPALLFIESKTLQGS---RGEHSFNSPGVFVVENTTIEFQKGADRQTFKIAGPLMADFIFKTR 334

  Fly   289 --------------KPMGFA------APDQLTCSGPISESLFIVMLVQEKNISLD-YEYSIPESL 332
                          :|:...      .|..:||.|....:....|.::.|.:..| |.:..||::
  Rat   335 YTVAKGSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECMDIRLKRVVPDHYCHYYPENV 399

  Fly   333 SHSQ-------------------------QDTHTWTHHQFNACSASCGGGSQSRKVTC---NNRI 369
            ....                         |....|.|:.:.|||.|||||.|.|...|   :...
  Rat   400 KPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHA 464

  Fly   370 TLAEVNPSLCDQKSKPVEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNRSITCERISSSGEHT 434
            .:.:|....|....||...|.|....| |.|:..|||:|:..||. |.:.|.:.|  |:..|:|.
  Rat   465 EILQVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQCTVTCGR-GLRYRVVLC--INHRGQHV 525

  Fly   435 ----------VEEDAV----CLKEVGNKP----------ATKQECNRDVKNCPKYHLGPWTPCDK 475
                      ::|:.|    |.|.....|          |.:.|..|.....||:...||:.|..
  Rat   526 GGCNPQMKLHIKEECVIPVPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPKFIPEPWSACST 590

  Fly   476 LCGDGKQTRKVTC--FIEENGHKRVLPEEDCVEEKPETEKSCLL--------------------- 517
            .||.|.|.|:|.|  .:.....:..||||:|...||.||:.|||
  Rat   591 TCGPGIQVREVRCRVLLTFTQTETELPEEECEGPKPPTERPCLLEACDHSPVSRELGGPLQEKDS 655

  Fly   518 -----------TPCEGV----------------------------------------------DW 525
                       |||...                                              .|
  Rat   656 EMIYDWEYAGFTPCTATCLGGYQEAIAVCLHIQTHQTVNDSLCDLAHRPPPMSQACHTEPCPPRW 720

  Fly   526 IISQWSGCNA-CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCS 589
            .:..|..|:| ||...:||...|.:.|....|.|.|..|.|...|.|....|...|...||.:|.
  Rat   721 HMGSWGACSATCGVGIQTRDVYCVHPEESPAPPEECRDEKPHALRACNQFDCPPSWHIEEWQQCP 785

  Fly   590 APCGKGVKSRIVICGEF--DGKTVTPADDDSKCNKETKPESEQDCEGEEKVCPGEWFTGPWGKCS 652
            ..||.|.::|.|.|.:.  ||..:..:|:  .| :..|..|.:.|...:  ||.:...|.|.|||
  Rat   786 RTCGGGTQNRRVTCRQLLTDGSFLNLSDE--LC-QGPKASSHKSCARTD--CPPQLAAGDWSKCS 845

  Fly   653 KPCGGGERVREVLCLSNGTK-------SVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIED 710
            ..||.|.:.|:.:|.....|       ...|.:....||...|....|::.::...|
  Rat   846 VTCGVGFQRRKQVCQKLTAKGRRVPLAETLCRDLPGLPLVRPCQMPVCSKLKLGMKT-------- 902

  Fly   711 DEEDCDEDGIELISDGLSD---DEKSEDVIDLEGTAKTETTPEAEDLMQSDS---PTPYDEFEST 769
               :..|.|.:::  |:..   ..:.|..|:|       |......|:.:.|   ..|...|:.:
  Rat   903 ---NLGERGPQIL--GVRRVYIQTREEKRINL-------TVGSRAYLLLNTSVIIKCPVRHFQKS 955

  Fly   770 GTTFEGSGYDSESTTDSGISTEGSGDDEETSEASTDLSSSTDSGSTSSDSTSSDSSSSISSDATS 834
            ...:|..|:..:::...||                     |.|||....|.|:.........|.|
  Rat   956 LIQWEKDGHCLKNSKQLGI---------------------TKSGSLKIHSLSTPDIGVYRCIAGS 999

  Fly   835 EAPASSVSDSSDSTDASTETTGVSDDSTDVSSSTEASASESTDVSGASDSTGSTNASDSTPESST 899
                            :.||..:....||.......|..|........|. ...|:..:|.....
  Rat  1000 ----------------AQETVVLKLIGTDNRLIAHPSLREHARAYPGLDH-NEANSLGATWHKMR 1047

  Fly   900 EASSSTDD----------------------STDSSDNSSNVSESSTEASSSSVSDSNDSSDGSTD 942
            :..:|.:|                      :::.:|||........||:....:.|.|
  Rat  1048 QLWNSKNDLYLHGGEINKQPFLRALFGPCRTSEGNDNSWEFKSKQFEAAMKQGAYSMD------- 1105

  Fly   943 GVSSTTENSSDSTSDATSDSTASSDSTDSTSDQTTETTPESSTDSTES------STLDASSTTDA 1001
                                ||..|.......|..| |.|:|.|....      :.|..:.....
  Rat  1106 --------------------TAQFDELIRNMSQLME-TGEASDDLASQMIYQLVAELAKAQPVQW 1149

  Fly  1002 SSTSESSSESSTDGSSTTSNSASSETTGLSSDGSTT-----------DATTAASDNTDITTD-GS 1054
            ..|.|....|.......|.....|.|  :.:.|..|           ....:.|.|..|... |:
  Rat  1150 RGTHEEVVASEAQFRGETGRVPKSPT--VKNPGKLTFKPKGPVLMRQTLPPSVSFNKTINARIGN 1212

  Fly  1055 TDESTDGSSNASTEGSTEGASEDTTISTESSGSTESTDAIASDGSTTEGSTVEDLSSSTSSDVTS 1119
            |...|.         |||..:...::.|.||   |:|.....||:.        |..|....|..
  Rat  1213 TVYITK---------STEVINILCSLVTPSS---EATYTWTKDGAL--------LQPSVKIIVDE 1257

  Fly  1120 DSTITDSSPSTEVSGSTDSS-SSTDGSSTDAS-----------STEASSTDVTESTDSTVSGG-- 1170
            ...:...:|:.:..|..:.| :|..||..::|           |.|.:.|....:..|.|.||
  Rat  1258 TGKMQIQNPTRKEQGIYECSVASHQGSDVESSLVLYAEAPVILSIERNVTKPEHNHLSVVVGGIV 1322

  Fly  1171 --------TSDTTESGPTEESTT----------------EGS-----TESTTEGSTDSTQSTDLD 1206
                    |......|..:.:.|                .||     .....||:...|.:..|.
  Rat  1323 EAALQANVTIHCPVKGVPQPNVTWLKRGGSLSDNVSLLFNGSLLLQNASLENEGTYICTATNALG 1387

  Fly  1207 S--TTSDIWSTSDKDDESESSTPYSFDSEVTKSKPRKCKPKKSTCAKSEYGCCPDGKSTPKGPFD 1269
            .  .||.:.....::..::::.|.:....|.::...:.....||           |||.|:..|.
  Rat  1388 KAVATSGLRLLERREPGNKTAFPKAQKKRVLQASKNRANSNNST-----------GKSLPQEYFW 1441

  Fly  1270 E-----GCPIAKTCADTKYGCCLDGVSPAKGKNNKGCPKSQC--------AETLFG--------- 1312
            |     .|  :.||                |.......:.||        :|.|.|
  Rat  1442 EPGNWTHC--SATC----------------GPLGVRLQRPQCMMASGQEVSEALCGPHRKPLAGF 1488

  Fly  1313 --C----CPDK-FTAADGENDEGC---PETTTVPPTTTTEETQPETTTEIEGSGQDSTTSEPDTK 1367
              |    ||.: ||:...|....|   ..:..|    ..::|:...|.::......::...|..:
  Rat  1489 QSCNIRDCPARWFTSMWSECSVSCGGGSHSRQV----MCKQTKANGTVQVVSPRACASKDRPLGR 1549

  Fly  1368 KSCSFSEFGCCPDAETSAKGPDFEG-C-GLA-------SPVAKGCA-ESENGCCPDGQTPA---- 1418
            |.||...   |....|.. |....| | |.|       :|    || .|.|..|.|.:..|
  Rat  1550 KPCSVRP---CAQQATDL-GSQCPGRCMGQAMRMQHHHTP----CAHNSSNSDCEDRRRLAFRRN 1606

  Fly  1419 --SGPNGEGCSGCTRERFGCCPDSQTPAHGPNKEGCCLDTQFGCCPDNILAARGPNNEGCECHYT 1481
              |||    |..|.|.             ||.|            |...:..||..:....|.:|
  Rat  1607 CTSGP----CEACWRV-------------GPWK------------PCTAVCGRGFQSRKVNCIHT 1642

  Fly  1482 PYGCCPDNKSAATGYNQEGCACETTQYGCCPDKITAAK---GPKHEGCPCETTQFGCCPDGLTFA 1543
              |.|   |..|..|             |...|..:.:   ||..:....:||.:  |    .|.
  Rat  1643 --GSC---KPMADRY-------------CVQMKPASWRHCFGPSCDRNCIDTTHY--C----MFV 1683

  Fly  1544 KGPHHHGCHCTQTEFKCC 1561
            |  |.:.|.....:.:||
  Rat  1684 K--HLNLCSLALYKQRCC 1699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	23/50 (46%)
		ADAM_spacer1	214..329	CDD:283607	23/159 (14%)
		TSP1	468..521	CDD:214559	24/86 (28%)
		TSP_1	645..693	CDD:278517	15/54 (28%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Adamtsl3	NP_001101003.2	TSP1	90..136	CDD:214559	23/50 (46%)
		TSP1	438..>458	CDD:214559	10/19 (53%)
		TSP1	498..>527	CDD:214559	12/31 (39%)
		TSP1	583..>603	CDD:214559	9/19 (47%)
		TSP1	720..773	CDD:214559	17/52 (33%)
		TSP1	839..894	CDD:214559	15/54 (28%)
		Ig	942..1006	CDD:299845	17/100 (17%)
		Ig	1223..1291	CDD:143165	17/78 (22%)
		IG_like	1313..1392	CDD:214653	13/78 (17%)
		IGc2	1329..1387	CDD:197706	8/57 (14%)
		TSP_1	1502..1557	CDD:278517	10/61 (16%)
		PLAC	1673..1703	CDD:285849	9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810