DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ppn and Cd22

DIOPT Version :9

Sequence 1:NP_788752.2 Gene:Ppn / 43872 FlyBaseID:FBgn0003137 Length:2898 Species:Drosophila melanogaster
Sequence 2:NP_001100973.1 Gene:Cd22 / 308501 RGDID:1311610 Length:852 Species:Rattus norvegicus


Alignment Length:603 Identity:121/603 - (20%)
Similarity:209/603 - (34%) Gaps:169/603 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  2334 ERRWYYDDEAGNCVSFIYAGCSGNQNNFRSFEACTNQCRPEPNKQDNEIG--------------- 2383
            |...|:..:  :.|:|:     ||::|     .||.:..|.......::|               
  Rat    87 ETELYFSQQ--DRVTFL-----GNRSN-----NCTLKIDPIHANDSGKLGLRLISGTDKWMEHIH 139

  Fly  2384 ----QNPCDTFDAECQELRCPYGVRRVAARSQPECTQCICENPCEGYSCPEGQQCAIDVA---SS 2441
                :.|...:      ::.|..:|    .||.....|.....|.||          |::   |.
  Rat   140 LNVSERPFQPY------IQLPSEIR----ESQRVSLTCGLNFTCFGY----------DISLRWSL 184

  Fly  2442 DDRQFAPVCRDIYKPGECPALSANASGCARECYTDADCRGDNKCCSDGCGQLC-VHPARPTQPPR 2505
            |..:.:||             :::.:......||::......|....|...:| |.........|
  Rat   185 DGSEVSPV-------------TSSITSSVENVYTESKLTFQPKWTDHGKSMMCQVWHFSQVLSER 236

  Fly  2506 TQAPVVSYPGDARAALEPKEAHELDVQTAIGGIAVLRC-FATGNPA---PNITWSLKNLVINTNK 2566
            |....|.|....:..:.|.|..|       |....:.| ..:.||:   ..::|......:...:
  Rat   237 TVRLDVKYTPKLQITVNPTEVKE-------GNSVTMTCQVNSSNPSLSTKKVSWFKDGSFLKEQQ 294

  Fly  2567 GRYVLTANGDLTIVQVRQTDDGTYVCVASNGLGEPVRREVALQVTEPVSQPA--YIY-GDKNVTQ 2628
                  ...:||:..|.:...|.|.|.|||.:|:...:||||.|..| .:|:  :|| ......|
  Rat   295 ------EQEELTLHSVTKDMRGKYQCRASNNIGQGQSKEVALTVLYP-PEPSKVHIYPSPAEEGQ 352

  Fly  2629 IVELNRPAVIRCPAGGFPE-PHVSWWRNGQMF-GLKNNLMARDYSLVFNSIQLSDLGLYTCEVYN 2691
            .|||      .|.:...|. .:.:|:.||:|. |      |....|..:::.|...|.|:|...|
  Rat   353 SVEL------ICDSLASPRATNYTWYHNGEMVPG------ASHEKLQISNVSLWHAGKYSCLAEN 405

  Fly  2692 QRR---------------PVSLRVTLKAVGPVR------------PLSPEEEQYMQYVLNPATRP 2729
            :..               |.::...:::|.|:|            ..:||..:| ::....:...
  Rat   406 RLGCGKIEQEAELDVHYVPKAVTTVIQSVTPIREGDSVTLDCRYNSSNPEVTKY-EWSPQGSGSE 469

  Fly  2730 VT------QRPSYPYRPTRPA-------YVPEPTVNVH------AVLALEPKNSYTPGSTIVMSC 2775
            ||      |:.::...|.:.|       :....::|||      .:|.:.|.:....|..:::.|
  Rat   470 VTPGVLRIQKATWDSPPIKCAACNYKCSWSFPVSLNVHYAPRAVKILKVSPASEIHAGQHVLLQC 534

  Fly  2776 SVQG-YP-EPNVTWIKDDVPLYNNERVQITYQPHRLVLSDVTSADSGKYTCRASNAYTYANGEAN 2838
            ...| :| |....|.|      |...||   :...|..|.::..|||.|.|...|:....:.:| 
  Rat   535 DFSGSFPTEVRFFWKK------NGNLVQ---EGRYLNFSSISPEDSGNYNCMVRNSIGETSSQA- 589

  Fly  2839 VSIQSV-------VPVSP 2849
            .|:|.:       |.:||
  Rat   590 WSLQVLYAPRRLRVSISP 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PpnNP_788752.2 TSP1 60..111 CDD:214559
ADAM_spacer1 214..329 CDD:283607
TSP1 468..521 CDD:214559
TSP_1 645..693 CDD:278517
Kunitz_BPTI 1611..1663 CDD:278443
Kunitz_BPTI 1670..1721 CDD:278443
Kunitz_BPTI 1729..1781 CDD:278443
Kunitz_BPTI 1789..1840 CDD:278443
Kunitz_BPTI 1848..1899 CDD:278443
KU 1920..1973 CDD:238057
Kunitz_BPTI 2001..2051 CDD:278443
KU 2071..2121 CDD:238057
Kunitz_BPTI 2127..2178 CDD:278443
KU 2192..2245 CDD:238057
KU 2251..2304 CDD:238057
KU 2316..2372 CDD:238057 9/37 (24%)
WAP 2457..2497 CDD:278522 6/40 (15%)
Ig 2521..2610 CDD:299845 22/92 (24%)
IG_like 2530..2610 CDD:214653 19/83 (23%)
IG_like 2627..2703 CDD:214653 19/92 (21%)
Ig 2636..2701 CDD:143165 15/81 (19%)
IG_like 2766..2841 CDD:214653 19/76 (25%)
Ig 2768..2830 CDD:299845 18/63 (29%)
PLAC 2851..2883 CDD:285849
Cd22NP_001100973.1 Ig 24..143 CDD:416386 11/67 (16%)
FR1 24..47 CDD:409353
Ig strand A 24..28 CDD:409353
Ig strand A' 31..35 CDD:409353
Ig strand B 37..48 CDD:409353
CDR1 48..56 CDD:409353
Ig strand C 56..63 CDD:409353
FR2 57..63 CDD:409353
CDR2 64..95 CDD:409353 2/7 (29%)
Ig strand C1 65..68 CDD:409353
Ig strand C2 71..75 CDD:409353
Ig strand C' 79..82 CDD:409353
FR3 96..129 CDD:409353 9/42 (21%)
Ig strand D 97..101 CDD:409353 1/3 (33%)
Ig strand E 106..114 CDD:409353 3/12 (25%)
Ig strand F 121..129 CDD:409353 1/7 (14%)
CDR3 130..132 CDD:409353 0/1 (0%)
FR4 133..143 CDD:409353 0/9 (0%)
Ig strand G 133..143 CDD:409353 0/9 (0%)
IgC1_CD22_d2 147..242 CDD:409532 21/127 (17%)
Ig strand B 163..167 CDD:409532 0/3 (0%)
Ig strand C 179..183 CDD:409532 0/3 (0%)
Ig strand E 207..211 CDD:409532 0/3 (0%)
Ig strand F 221..226 CDD:409532 1/4 (25%)
Ig strand G 235..238 CDD:409532 1/2 (50%)
Ig 246..334 CDD:416386 23/100 (23%)
Ig strand A 246..253 CDD:409353 0/6 (0%)
Ig strand B 260..270 CDD:409353 2/9 (22%)
Ig strand C 277..285 CDD:409353 1/7 (14%)
Ig strand C' 287..290 CDD:409353 0/2 (0%)
Ig strand E 296..303 CDD:409353 2/6 (33%)
Ig strand F 310..318 CDD:409353 4/7 (57%)
Ig strand G 321..334 CDD:409353 6/12 (50%)
IGc2 350..408 CDD:197706 18/69 (26%)
Ig strand B 354..358 CDD:409353 3/9 (33%)
Ig strand C 367..372 CDD:409353 0/4 (0%)
Ig strand F 398..403 CDD:409353 2/4 (50%)
Ig 424..>466 CDD:416386 7/42 (17%)
Ig strand A 424..431 CDD:409353 1/6 (17%)
Ig strand A' 435..439 CDD:409353 1/3 (33%)
Ig strand B 440..450 CDD:409353 0/9 (0%)
Ig strand C 457..463 CDD:409353 1/6 (17%)
IGc2 527..583 CDD:197706 18/64 (28%)
Ig strand B 530..534 CDD:409353 0/3 (0%)
Ig strand C 543..549 CDD:409353 1/5 (20%)
Ig strand F 573..578 CDD:409353 2/4 (50%)
IG 610..682 CDD:214652
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4475
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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